PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19112469-5 2008 Moreover, the flavonoid decreased Hsp27, procaspase-3, MRP and PKB expression in neuroblastoma cells and in neurons. Flavonoids 14-23 ATP binding cassette subfamily C member 1 Homo sapiens 55-58 18225583-4 2007 RESULTS: Effective MRP1 inhibitors were identified among the stilbenes (piceatannol and its derivatives) and the flavonoids (aromadendrin, naringenin and its derivatives). Flavonoids 113-123 ATP binding cassette subfamily C member 1 Homo sapiens 19-23 17509533-1 2007 The present study characterises the effect of phase II metabolism, especially methylation and glucuronidation, of the model flavonoid quercetin on its capacity to inhibit human MRP1 and MRP2 activity in Sf9 inside-out vesicles. Flavonoids 124-133 ATP binding cassette subfamily C member 1 Homo sapiens 177-181 17345086-3 2007 Here we show the reversal effects of an extensive panel of flavonoids upon BCRP-, P-gp-, and MRP1-mediated drug resistance. Flavonoids 59-69 ATP binding cassette subfamily C member 1 Homo sapiens 93-97 17345086-4 2007 METHODS: Reversal effects of flavonoids upon BCRP-, P-gp-, or MRP1-mediated drug resistance were examined in the BCRP- or MDR1-transduced human leukemia K562 cells or in the MRP1-transfected human epidermoid carcinoma KB-3-1 cells using cell growth inhibition assays. Flavonoids 29-39 ATP binding cassette subfamily C member 1 Homo sapiens 62-66 17509533-6 2007 This finding indicates that phase II metabolism of quercetin could enhance the potential use of quercetin- or flavonoids in general-as an inhibitor to overcome MRP-mediated multidrug resistance. Flavonoids 110-120 ATP binding cassette subfamily C member 1 Homo sapiens 160-163 15581599-1 2005 Multidrug resistance transporter MRP1 could be effectively inhibited by some flavonoids. Flavonoids 77-87 ATP binding cassette subfamily C member 1 Homo sapiens 33-37 15916776-0 2005 Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids. Flavonoids 74-84 ATP binding cassette subfamily C member 1 Homo sapiens 14-18 15916776-1 2005 The influence of novel synthetic and plant origin flavonoids on activity of multidrug resistance-associated protein (MRP1) was investigated in human erythrocytes used as a cell model expressing MRP1 in plasma membrane. Flavonoids 50-60 ATP binding cassette subfamily C member 1 Homo sapiens 76-121 15916776-1 2005 The influence of novel synthetic and plant origin flavonoids on activity of multidrug resistance-associated protein (MRP1) was investigated in human erythrocytes used as a cell model expressing MRP1 in plasma membrane. Flavonoids 50-60 ATP binding cassette subfamily C member 1 Homo sapiens 117-121 15916776-4 2005 Most of the flavonoids showed strong or moderate ability to inhibit transport carried out by MRP1. Flavonoids 12-22 ATP binding cassette subfamily C member 1 Homo sapiens 93-97 16997339-5 2006 Additional experiments revealed that the apical to basolateral PhIP transport was also increased in the presence of a typical BCRP or MRP inhibitor with apparent Ki values in the same range as those of the flavonoids. Flavonoids 206-216 ATP binding cassette subfamily C member 1 Homo sapiens 134-137 16081670-2 2005 The interactions of flavonoids with some major efflux transporters [e.g., P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein] have been reported; however, their interactions with uptake transporters are largely unknown. Flavonoids 20-30 ATP binding cassette subfamily C member 1 Homo sapiens 90-131 16081670-2 2005 The interactions of flavonoids with some major efflux transporters [e.g., P-glycoprotein, multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein] have been reported; however, their interactions with uptake transporters are largely unknown. Flavonoids 20-30 ATP binding cassette subfamily C member 1 Homo sapiens 133-137 16156793-10 2005 Collectively, these results suggest that dietary flavonoids such as quercetin and silymarin can modulate transport activities of MRP1, -4 and -5. Flavonoids 49-59 ATP binding cassette subfamily C member 1 Homo sapiens 129-144 14618263-0 2003 Multiple flavonoid-binding sites within multidrug resistance protein MRP1. Flavonoids 9-18 ATP binding cassette subfamily C member 1 Homo sapiens 69-73 15041478-0 2004 Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells. Flavonoids 32-41 ATP binding cassette subfamily C member 1 Homo sapiens 100-104 15041478-1 2004 The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5). Flavonoids 207-217 ATP binding cassette subfamily C member 1 Homo sapiens 148-152 15041478-1 2004 The objective of this study was to investigate the structural requirements necessary for inhibition of glutathione S-transferase P1-1 (GSTP1-1) and GS-X pump (MRP1 and MRP2) activity by structurally related flavonoids, in GSTP1-1 transfected MCF7 cells (pMTG5). Flavonoids 207-217 ATP binding cassette subfamily C member 1 Homo sapiens 159-163 15041478-6 2004 Most flavonoids appeared to be potent GS-X transport inhibitors with IC(50) values ranging between 0.8 and 8microM. Flavonoids 5-15 ATP binding cassette subfamily C member 1 Homo sapiens 38-42 15102949-3 2004 The interactions of flavonoids with P-glycoprotein and multidrug resistance-associated protein 1 have been reported; however, their interaction with BCRP is unknown. Flavonoids 20-30 ATP binding cassette subfamily C member 1 Homo sapiens 55-96 15041478-11 2004 To identify the GS-X pump responsible for the DNP-SG efflux in MCF7 cells, the effects of three characteristic flavonoids quercetin, flavone and taxifolin on MRP1 and MRP2 activity were studied using transfected MDCKII cells. Flavonoids 111-121 ATP binding cassette subfamily C member 1 Homo sapiens 16-20 15041478-12 2004 All three flavonoids as well as the typical MRP inhibitor (MK571) affected MRP1-mediated transport activity in a similar way as observed in the MCF7 cells. Flavonoids 10-20 ATP binding cassette subfamily C member 1 Homo sapiens 75-79 15041478-14 2004 These observations clearly indicate that the GS-X pump activity in the MCF7 cells is likely to be the result of flavonoid-mediated inhibition of MRP1 and not MRP2. Flavonoids 112-121 ATP binding cassette subfamily C member 1 Homo sapiens 45-49 15041478-14 2004 These observations clearly indicate that the GS-X pump activity in the MCF7 cells is likely to be the result of flavonoid-mediated inhibition of MRP1 and not MRP2. Flavonoids 112-121 ATP binding cassette subfamily C member 1 Homo sapiens 145-149 15041478-15 2004 Altogether, the present study reveals that a major site for flavonoid interaction with GSH-dependent toxicokinetics is the GS-X pump MRP1 rather than the conjugating GSTP1-1 activity itself. Flavonoids 60-69 ATP binding cassette subfamily C member 1 Homo sapiens 123-127 15041478-15 2004 Altogether, the present study reveals that a major site for flavonoid interaction with GSH-dependent toxicokinetics is the GS-X pump MRP1 rather than the conjugating GSTP1-1 activity itself. Flavonoids 60-69 ATP binding cassette subfamily C member 1 Homo sapiens 133-137 14618263-1 2003 Recombinant nucleotide-binding domains (NBDs) from human multidrug resistance protein MRP1 were overexpressed in bacteria and purified to measure their direct interaction with high-affinity flavonoids, and to evaluate a potential correlation with inhibition of MRP1-mediated transport activity and reversion of cellular multidrug resistance. Flavonoids 190-200 ATP binding cassette subfamily C member 1 Homo sapiens 86-90 12532374-0 2003 Effect of flavonoids on MRP1-mediated transport in Panc-1 cells. Flavonoids 10-20 ATP binding cassette subfamily C member 1 Homo sapiens 24-28 12532374-9 2003 These results therefore indicate that the flavonoids morin, chalcone, silymarin, phloretin, genistein, quercetin, biochanin A, and kaempferol can inhibit MRP1-mediated drug transport, effects that may involve binding interactions with MRP1, as well as modulation of GSH concentrations. Flavonoids 42-52 ATP binding cassette subfamily C member 1 Homo sapiens 154-158 12532374-9 2003 These results therefore indicate that the flavonoids morin, chalcone, silymarin, phloretin, genistein, quercetin, biochanin A, and kaempferol can inhibit MRP1-mediated drug transport, effects that may involve binding interactions with MRP1, as well as modulation of GSH concentrations. Flavonoids 42-52 ATP binding cassette subfamily C member 1 Homo sapiens 235-239 12812360-8 2003 Our results indicate that flavonoid molecular structure provides a promising base for development of potent MRP1 inhibitors. Flavonoids 26-35 ATP binding cassette subfamily C member 1 Homo sapiens 108-112 12812360-0 2003 Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes. Flavonoids 0-10 ATP binding cassette subfamily C member 1 Homo sapiens 28-32 9280310-5 1997 The present data are consistent with the hypothesis that certain (iso)flavonoids affect MRP-mediated transport of anticancer drugs by a direct interaction with MRP. Flavonoids 70-80 ATP binding cassette subfamily C member 1 Homo sapiens 88-91 11306701-0 2001 Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. Flavonoids 118-128 ATP binding cassette subfamily C member 1 Homo sapiens 51-56 9280310-5 1997 The present data are consistent with the hypothesis that certain (iso)flavonoids affect MRP-mediated transport of anticancer drugs by a direct interaction with MRP. Flavonoids 70-80 ATP binding cassette subfamily C member 1 Homo sapiens 160-163 27984000-6 2017 This result portends the flavonoid dimer 4e as a very promising compound to appraise in vivo the therapeutic potential of collateral sensitivity for eradication of MRP1-overexpressing chemoresistant cancer cells in tumors. Flavonoids 25-34 ATP binding cassette subfamily C member 1 Homo sapiens 164-168 32664838-6 2020 In particular, para-cellular pathway also participated in the transport of IV, ST, IVG and S. Furthermore, the efflux process of six flavonoids was mediated by Pglycoprotein (P-gp) and multidrug resistance protein (MRP), which may result in a decrease of bioavailability. Flavonoids 133-143 ATP binding cassette subfamily C member 1 Homo sapiens 185-213 32664838-6 2020 In particular, para-cellular pathway also participated in the transport of IV, ST, IVG and S. Furthermore, the efflux process of six flavonoids was mediated by Pglycoprotein (P-gp) and multidrug resistance protein (MRP), which may result in a decrease of bioavailability. Flavonoids 133-143 ATP binding cassette subfamily C member 1 Homo sapiens 215-218 30351934-0 2018 Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry". Flavonoids 19-28 ATP binding cassette subfamily C member 1 Homo sapiens 79-83 30351934-0 2018 Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry". Flavonoids 19-28 ATP binding cassette subfamily C member 1 Homo sapiens 85-90 30351934-1 2018 A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using "click chemistry". Flavonoids 13-22 ATP binding cassette subfamily C member 1 Homo sapiens 40-81 30351934-1 2018 A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using "click chemistry". Flavonoids 13-22 ATP binding cassette subfamily C member 1 Homo sapiens 83-87 30351934-1 2018 A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using "click chemistry". Flavonoids 13-22 ATP binding cassette subfamily C member 1 Homo sapiens 89-94 27984000-0 2017 Flavonoid dimers are highly potent killers of multidrug resistant cancer cells overexpressing MRP1. Flavonoids 0-9 ATP binding cassette subfamily C member 1 Homo sapiens 94-98 27984000-1 2017 MRP1 overexpression in multidrug-resistant cancer cells has been shown to be responsible for collateral sensitivity to some flavonoids that stimulate a huge MRP1-mediated GSH efflux. Flavonoids 124-134 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 27984000-1 2017 MRP1 overexpression in multidrug-resistant cancer cells has been shown to be responsible for collateral sensitivity to some flavonoids that stimulate a huge MRP1-mediated GSH efflux. Flavonoids 124-134 ATP binding cassette subfamily C member 1 Homo sapiens 157-161 27984000-3 2017 We describe here that bivalent flavonoid dimers strikingly stimulate such MRP1-mediated GSH efflux and trigger a 50-100 fold more potent cell death than their corresponding monomers. Flavonoids 31-40 ATP binding cassette subfamily C member 1 Homo sapiens 74-78 27984000-5 2017 The best flavonoid dimer, 4e, kills MRP1-overexpressing cells with a selective ratio higher than 1000 compared to control cells and an EC50 value of 0.1 muM, so far unequaled as a collateral sensitivity agent targeting ABC transporters. Flavonoids 9-18 ATP binding cassette subfamily C member 1 Homo sapiens 36-40 25204184-1 2014 To study the quantitative structure-activity relationship (QSAR) between the stuctures of 29 flavonoids and the inhibitory activity of their multidrug resistance-associated protein (MRP) 1 and 2 by using the comparative molecular similarity index analysis (CoMSIA). Flavonoids 93-103 ATP binding cassette subfamily C member 1 Homo sapiens 141-194 26774038-0 2016 Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization. Flavonoids 0-9 ATP binding cassette subfamily C member 1 Homo sapiens 35-40 25204184-2 2014 By studying the impact of the combination of different molecular force fields, researchers obtained the molecular force fields that played an important role in inhibiting the activity of MRP1 and MRP2, built the optimized QSAR model, and discussed the structural modification method for flavonoids" multidrug resistance-associated protein inhibitor. Flavonoids 287-297 ATP binding cassette subfamily C member 1 Homo sapiens 187-191 25204184-3 2014 The results of the study could not only provide the guidance for new drug R&D, but also help partially discuss the synergy mechanism between MRP1 and MRP2 receptors and traditional Chinese medicines containing flavonoids. Flavonoids 214-224 ATP binding cassette subfamily C member 1 Homo sapiens 145-149 24956120-2 2014 Eight flavonoids isolated from traditional Chinese medicine Sophora alopecuroides L. were applied to test their effect on MDR associated protein 1 (MRP1) through the established predicting assay. Flavonoids 6-16 ATP binding cassette subfamily C member 1 Homo sapiens 148-152 20645919-4 2010 In our previous work we studied modulation of MDR in cancer cells expressing P-gp or MRP1 by selected carotenoids, flavonoids and extracts from medically important Chinese plants. Flavonoids 115-125 ATP binding cassette subfamily C member 1 Homo sapiens 85-89 21728961-5 2011 Interestingly, inhibitory flavonoids are quite specific for ABCG2 versus ABCB1 and ABCC1, and appear either non-competitive or partially competitive towards mitoxantrone efflux. Flavonoids 26-36 ATP binding cassette subfamily C member 1 Homo sapiens 83-88 22583399-3 2012 Plant-origin polyphenolic compounds, mainly flavonoids and stilbenes or their synthetic derivatives, can modulate the main ABC transporters responsible for cancer drug resistance, including P-glycoprotein, MRP1 and BCRP. Flavonoids 44-54 ATP binding cassette subfamily C member 1 Homo sapiens 206-210 22187677-0 2011 Interaction of phenothiazines, stilbenes and flavonoids with multidrug resistance-associated transporters, P-glycoprotein and MRP1. Flavonoids 45-55 ATP binding cassette subfamily C member 1 Homo sapiens 126-130 22187677-5 2011 In the present review, interactions of three groups of modulators: phenothiazines, flavonoids and stilbenes with both P-glycoprotein and MRP1 are discussed. Flavonoids 83-93 ATP binding cassette subfamily C member 1 Homo sapiens 137-141 20633549-3 2010 Functional test based on the transport of fluorescent substrate BCECF revealed that the flavonoid strongly inhibited MRP1 transport activity in human erythrocytes (IC(50)=5.76+/-1.80muM). Flavonoids 88-97 ATP binding cassette subfamily C member 1 Homo sapiens 117-121 19725578-2 2009 Flavonoid dimers bearing five or six ethylene glycol (EG) units with 6-methyl (4e, 4f) or 7-methyl (5e, 5f) substitution on the ring A of flavonoid dimers have the highest modulating activity for DOX against MRP1 with an EC(50) ranging from 73 to 133 nM. Flavonoids 0-9 ATP binding cassette subfamily C member 1 Homo sapiens 208-212 19725578-3 2009 At 0.5 microM, the flavonoid dimer 4e was sufficient to restore DOX accumulation in 2008/MRP1 to parental 2008/P level. Flavonoids 19-28 ATP binding cassette subfamily C member 1 Homo sapiens 89-93 19725578-5 2009 Our data suggest that flavonoid dimers have a high affinity toward binding to DOX recognition site of MRP1. Flavonoids 22-31 ATP binding cassette subfamily C member 1 Homo sapiens 102-106 19725578-7 2009 The present study demonstrates that flavonoid dimers can be employed as an effective modulator of MRP1-mediated drug resistance in cancer cells. Flavonoids 36-45 ATP binding cassette subfamily C member 1 Homo sapiens 98-102 19020811-3 2009 All the flavonoids inhibited the efflux of MRP1 fluorescent substrate from human erythrocytes and breast cancer cells. Flavonoids 8-18 ATP binding cassette subfamily C member 1 Homo sapiens 43-47 19020811-8 2009 We concluded that mechanisms other than perturbation of the lipid phase of membranes were responsible for inhibition of MRP1 by the flavonoids. Flavonoids 132-142 ATP binding cassette subfamily C member 1 Homo sapiens 120-124