PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15545828-0 2004 The peroxisome proliferator-activated receptor-gamma ligand 15-deoxyDelta12,14 prostaglandin J2 reduces the organ injury in hemorrhagic shock. 9-deoxy-delta-9-prostaglandin D2 79-95 peroxisome proliferator-activated receptor gamma Rattus norvegicus 4-52 18278065-5 2008 KEY RESULTS: In growth-arrested cardiac fibroblasts, PPAR-gamma ligands rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) dose-dependently attenuated Ang II-induced cell proliferation and expression of PAI-1, collagen type-I, collagen type-III and fibronectin. 9-deoxy-delta-9-prostaglandin D2 112-128 peroxisome proliferator-activated receptor gamma Rattus norvegicus 53-63 16794398-8 2006 Plasma 15-deoxy-Delta12, 14-prostaglandin J2 (PGJ2, an endogenous PPAR-gamma agonist) levels were also increased in androstenediol-treated T-H rats, but these levels were lower than those observed in shams. 9-deoxy-delta-9-prostaglandin D2 46-50 peroxisome proliferator-activated receptor gamma Rattus norvegicus 66-76 15994020-7 2005 The natural peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-delta(12,14) prostaglandin J2, and the cyclic AMP analog, bromo cyclic AMP, significantly attenuated the strong induction of peroxisome proliferator-activated receptor-gamma and inducible nitric oxide synthase, while they partially reversed the inhibitory effect of OTA on glial fibrillary acidic protein. 9-deoxy-delta-9-prostaglandin D2 91-107 peroxisome proliferator-activated receptor gamma Rattus norvegicus 12-60 15994020-7 2005 The natural peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-delta(12,14) prostaglandin J2, and the cyclic AMP analog, bromo cyclic AMP, significantly attenuated the strong induction of peroxisome proliferator-activated receptor-gamma and inducible nitric oxide synthase, while they partially reversed the inhibitory effect of OTA on glial fibrillary acidic protein. 9-deoxy-delta-9-prostaglandin D2 91-107 peroxisome proliferator-activated receptor gamma Rattus norvegicus 203-251 30193217-2 2018 Herein, we designed additional derivatives containing an exocyclic enone moiety that resembles the key structure of the natural PPAR-gamma ligand, 15-deoxy-Delta12, 14-prostaglandin J2 (15 d-PGJ2). 9-deoxy-delta-9-prostaglandin D2 190-195 peroxisome proliferator-activated receptor gamma Rattus norvegicus 128-138 30193217-3 2018 The exocyclic enone moiety of 15 d-PGJ2 is essential for covalent bonding with the Cys285 residue in the PPAR-gamma ligand-binding domain (LBD). 9-deoxy-delta-9-prostaglandin D2 35-39 peroxisome proliferator-activated receptor gamma Rattus norvegicus 105-115 19262292-6 2009 The lung maturation effect of PPARgamma agonists was also confirmed by another PPARgamma agonist, the naturally occurring PPARgamma ligand prostaglandin J2. 9-deoxy-delta-9-prostaglandin D2 139-155 peroxisome proliferator-activated receptor gamma Rattus norvegicus 30-39 19262292-6 2009 The lung maturation effect of PPARgamma agonists was also confirmed by another PPARgamma agonist, the naturally occurring PPARgamma ligand prostaglandin J2. 9-deoxy-delta-9-prostaglandin D2 139-155 peroxisome proliferator-activated receptor gamma Rattus norvegicus 79-88 19262292-6 2009 The lung maturation effect of PPARgamma agonists was also confirmed by another PPARgamma agonist, the naturally occurring PPARgamma ligand prostaglandin J2. 9-deoxy-delta-9-prostaglandin D2 139-155 peroxisome proliferator-activated receptor gamma Rattus norvegicus 79-88 18047631-3 2008 The aim of the present study was to test whether PPAR-gamma agonists 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ2) and pioglitazone could alter AngII-induced collagen type I formation in vascular adventitial fibroblasts via reactive oxygen species (ROS). 9-deoxy-delta-9-prostaglandin D2 114-119 peroxisome proliferator-activated receptor gamma Rattus norvegicus 49-59 14600076-1 2004 Peroxisome proliferator-activated receptor (PPAR)gamma agonists, such as 15-deoxy-delta 12,14-prostaglandin J2 (PGJ2) and troglitazone, have been shown to elicit anti-inflammatory effects in pancreatic beta-cells that include inhibition of cytokine-stimulated inducible nitric oxide synthase (iNOS) gene expression and production of nitric oxide. 9-deoxy-delta-9-prostaglandin D2 112-116 peroxisome proliferator-activated receptor gamma Rattus norvegicus 44-48 14600076-3 2004 The purpose of this study was to determine if PPARgamma activation participates in the anti-inflammatory actions of PGJ2 in beta-cells. 9-deoxy-delta-9-prostaglandin D2 116-120 peroxisome proliferator-activated receptor gamma Rattus norvegicus 46-55 14600076-6 2004 Although these agents fail to attenuate the inhibitory actions of PGJ2 on cytokine signaling, they do inhibit PGJ2-stimulated PPARgamma response element reporter activity. 9-deoxy-delta-9-prostaglandin D2 110-114 peroxisome proliferator-activated receptor gamma Rattus norvegicus 126-135 15090969-11 2004 The specific PPAR-gamma antagonist GW9662 reduced the protective effects afforded by 15 d-PGJ2. 9-deoxy-delta-9-prostaglandin D2 89-94 peroxisome proliferator-activated receptor gamma Rattus norvegicus 13-23 15090969-0 2004 Role of peroxisome proliferator-activated receptor-gamma in the protection afforded by 15-deoxydelta12,14 prostaglandin J2 against the multiple organ failure caused by endotoxin. 9-deoxy-delta-9-prostaglandin D2 106-122 peroxisome proliferator-activated receptor gamma Rattus norvegicus 8-56 15090969-14 2004 The mechanisms of the protective effect of this cyclopentenone prostaglandin are--at least in part--PPAR-gamma dependent, as the protection afforded by 15 d-PGJ2 was reduced by the PPAR-gamma antagonist GW9662. 9-deoxy-delta-9-prostaglandin D2 157-161 peroxisome proliferator-activated receptor gamma Rattus norvegicus 100-110 15090969-14 2004 The mechanisms of the protective effect of this cyclopentenone prostaglandin are--at least in part--PPAR-gamma dependent, as the protection afforded by 15 d-PGJ2 was reduced by the PPAR-gamma antagonist GW9662. 9-deoxy-delta-9-prostaglandin D2 157-161 peroxisome proliferator-activated receptor gamma Rattus norvegicus 181-191 15090969-15 2004 We propose that 15 d-PGJ2 or other ligands for PPAR-gamma may be useful in treating organ injury associated with endotoxic shock. 9-deoxy-delta-9-prostaglandin D2 21-25 peroxisome proliferator-activated receptor gamma Rattus norvegicus 47-57 10205228-9 1999 No expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) was detected in VSMC, and 15-deoxy-D12,14 prostaglandin J2, the natural ligand for the PPARgamma, did not resemble the effect of troglitazone on IL-1-induced NO synthesis. 9-deoxy-delta-9-prostaglandin D2 120-136 peroxisome proliferator-activated receptor gamma Rattus norvegicus 165-174 11996104-4 2000 PPARgamma were expressed in VSMC and RAW cells and their activity was upregulated in the presence of PGJ2 and ciglitazone. 9-deoxy-delta-9-prostaglandin D2 101-105 peroxisome proliferator-activated receptor gamma Rattus norvegicus 0-9 10203248-1 1999 The peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by 15-deoxy-delta(12,14) prostaglandin J2 (15d-PGJ2), anti-diabetic thiazolidinediones and several non-steroidal anti-inflammatory drugs (NSAIDs). 9-deoxy-delta-9-prostaglandin D2 103-119 peroxisome proliferator-activated receptor gamma Rattus norvegicus 4-52 10203248-1 1999 The peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by 15-deoxy-delta(12,14) prostaglandin J2 (15d-PGJ2), anti-diabetic thiazolidinediones and several non-steroidal anti-inflammatory drugs (NSAIDs). 9-deoxy-delta-9-prostaglandin D2 103-119 peroxisome proliferator-activated receptor gamma Rattus norvegicus 54-63 9239419-5 1997 9-cis or all-trans retinoic acid, 1,25 dihydroxyvitamin D3, or the PPARgamma ligands prostaglandin J2 or troglitazone did not affect the development of barrier function or epidermal morphology. 9-deoxy-delta-9-prostaglandin D2 85-101 peroxisome proliferator-activated receptor gamma Rattus norvegicus 67-76 9518257-4 1998 PEPCK mRNA is similarly induced by the natural ligand of PPARgamma, the 15-deoxy-delta(12-14) prostaglandin J2. 9-deoxy-delta-9-prostaglandin D2 94-110 peroxisome proliferator-activated receptor gamma Rattus norvegicus 57-66 35380292-9 2022 RESULTS: Serum creatinine, urea nitrogen and glucose, and PPARgamma and GLUT1 expression in rat PF model were reduced by PPARgamma agonists Rosiglitazone or 15d-PGJ2 and elevated by antagonist GW9662. 9-deoxy-delta-9-prostaglandin D2 160-165 peroxisome proliferator-activated receptor gamma Rattus norvegicus 58-67 35380292-9 2022 RESULTS: Serum creatinine, urea nitrogen and glucose, and PPARgamma and GLUT1 expression in rat PF model were reduced by PPARgamma agonists Rosiglitazone or 15d-PGJ2 and elevated by antagonist GW9662. 9-deoxy-delta-9-prostaglandin D2 160-165 peroxisome proliferator-activated receptor gamma Rattus norvegicus 121-130