PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15523637-6	2004	However, the selective PPARgamma agonist ciglitazone failed to up-regulate COX-2, indicating that the PGJ2 effect on COX-2 is PPARgamma independent.	9-deoxy-delta-9-prostaglandin D2	102-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	117-122	
15523637-3	2004	Here we demonstrate that PGJ2 enhances COX-2 gene expression without elevating COX-1 levels in neuronal cells.	9-deoxy-delta-9-prostaglandin D2	25-29	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44	
15523637-4	2004	PGJ2 also increased PGE2 production, establishing that the de novo synthesized COX-2 is enzymatically active.	9-deoxy-delta-9-prostaglandin D2	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	79-84	
23817787-9	2013	The results suggest that the inducible COX-2 can contribute to the endogenous synthesis of PGJ2 derivatives acting as autocrine mediators to simulate adipogenesis during the maturation phase by way of compensation for the suppressed expression of the constitutive COX-1.	9-deoxy-delta-9-prostaglandin D2	91-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	39-44	
15523637-11	2004	The proinflammatory cytokine may mediate COX-2 up-regulation by PGJ2 through p38MAPK and not JNK activation, in that only an inhibitor of the former prevented the COX-2 increase.	9-deoxy-delta-9-prostaglandin D2	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46	
15523637-11	2004	The proinflammatory cytokine may mediate COX-2 up-regulation by PGJ2 through p38MAPK and not JNK activation, in that only an inhibitor of the former prevented the COX-2 increase.	9-deoxy-delta-9-prostaglandin D2	64-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	163-168	
15523637-13	2004	Collectively, our findings suggest that proinflammatory conditions that lead to COX-2 up-regulation and the concomitant production of PGJ2 initiate a mechanism of self-destruction through an autotoxic loop between PGJ2 and COX-2 that may exacerbate neurodegeneration beyond a point of no return.	9-deoxy-delta-9-prostaglandin D2	134-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	223-228	
15523637-13	2004	Collectively, our findings suggest that proinflammatory conditions that lead to COX-2 up-regulation and the concomitant production of PGJ2 initiate a mechanism of self-destruction through an autotoxic loop between PGJ2 and COX-2 that may exacerbate neurodegeneration beyond a point of no return.	9-deoxy-delta-9-prostaglandin D2	214-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85	
12432912-8	2002	The induction of COX-2 is suppressed by dexamethasone and PGJ2.	9-deoxy-delta-9-prostaglandin D2	58-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22