PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15047157-2 2004 In the present study, harmine was identified from a collection of herbal compounds to be a specific inhibitor of Cdk1/cyclin B, Cdk2/cyclin A, and Cdk5/p25 with IC50 values at low micromoles. Harmine 22-29 cyclin dependent kinase 1 Homo sapiens 113-117 15047157-4 2004 The CDK inhibition by harmine is competitive with ATP-Mg2+, suggesting that it binds to the ATP-Mg2+-binding pocket of CDKs. Harmine 22-29 cyclin dependent kinase 1 Homo sapiens 119-123 15047157-7 2004 Taken together, harmine is a selective inhibitor of CDKs and cell proliferation. Harmine 16-23 cyclin dependent kinase 1 Homo sapiens 52-56