PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34952543-3 2021 Therefore, 18 179 mRNA expression maps (based on the Allen Human Brain Atlas) were correlated with the cerebral distribution volume (VT) of MAO-A assessed in 36 healthy subjects (mean age +- standard deviation: 32.9 +- 8.8 years, 18 female) using (11C)harmine positron emission tomography scans. Harmine 252-259 monoamine oxidase A Homo sapiens 140-145 33339338-1 2020 The beta-carboline alkaloid harmine is a potent DYRK1A inhibitor, but suffers from undesired potent inhibition of MAO-A, which strongly limits its application. Harmine 28-35 monoamine oxidase A Homo sapiens 114-119 33339338-2 2020 We synthesized more than 60 analogues of harmine, either by direct modification of the alkaloid or by de novo synthesis of beta-carboline and related scaffolds aimed at learning about structure-activity relationships for inhibition of both DYRK1A and MAO-A, with the ultimate goal of separating desired DYRK1A inhibition from undesired MAO-A inhibition. Harmine 41-48 monoamine oxidase A Homo sapiens 251-256 33339338-2 2020 We synthesized more than 60 analogues of harmine, either by direct modification of the alkaloid or by de novo synthesis of beta-carboline and related scaffolds aimed at learning about structure-activity relationships for inhibition of both DYRK1A and MAO-A, with the ultimate goal of separating desired DYRK1A inhibition from undesired MAO-A inhibition. Harmine 41-48 monoamine oxidase A Homo sapiens 336-341 29423903-0 2018 [11C]Harmine Binding to Brain Monoamine Oxidase A: Test-Retest Properties and Noninvasive Quantification. Harmine 5-12 monoamine oxidase A Homo sapiens 30-49 32380384-10 2020 Harmine, Clorgyline, Isatin, zonisamide and our title compound including are known with their competitive inhibitory activity on Human monoamine oxidase, commonly named MAO A and B. Harmine 0-7 monoamine oxidase A Homo sapiens 169-180 28264138-3 2017 On the other hand, harmine is also a potent inhibitor of monoamine oxidase A (MAO-A). Harmine 19-26 monoamine oxidase A Homo sapiens 57-76 29788780-4 2018 Conclusion & future perspective: The current study delineates the structural requirements for MAO-A selectivity and such information may be helpful in designing selective analogs for kinase, DYRK1A and harmine-based cytotoxics without apparent MAO enzyme inhibition. Harmine 206-213 monoamine oxidase A Homo sapiens 98-103 28264138-3 2017 On the other hand, harmine is also a potent inhibitor of monoamine oxidase A (MAO-A). Harmine 19-26 monoamine oxidase A Homo sapiens 78-83 24898155-0 2014 Greater monoamine oxidase a binding in perimenopausal age as measured with carbon 11-labeled harmine positron emission tomography. Harmine 93-100 monoamine oxidase A Homo sapiens 8-27 26192590-4 2015 Here we characterized a series of novel harmine analogs with minimal or absent MAO-A inhibitory activity. Harmine 40-47 monoamine oxidase A Homo sapiens 79-84 23403377-1 2013 Positron emission tomography (PET) imaging of monoamine oxidases (MAO-A: [(11)C]harmine, [(11)C]clorgyline, and [(11)C]befloxatone; MAO-B: [(11)C]deprenyl-D2) has been actively pursued given clinical importance of MAOs in human neuropsychiatric disorders. Harmine 80-87 monoamine oxidase A Homo sapiens 66-71 24154665-4 2014 MAO-A VT (an index of MAO-A density) was measured using [(11)C]harmine positron emission tomography (PET) in 42 subjects with MDEs secondary to major depressive disorder and 37 healthy controls. Harmine 63-70 monoamine oxidase A Homo sapiens 0-5 24154665-4 2014 MAO-A VT (an index of MAO-A density) was measured using [(11)C]harmine positron emission tomography (PET) in 42 subjects with MDEs secondary to major depressive disorder and 37 healthy controls. Harmine 63-70 monoamine oxidase A Homo sapiens 22-27 21463543-0 2011 Monoamine oxidase A inhibitor occupancy during treatment of major depressive episodes with moclobemide or St. John"s wort: an [11C]-harmine PET study. Harmine 132-139 monoamine oxidase A Homo sapiens 0-19 22186668-2 2012 We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [(11)C]-harmine positron emission tomography in healthy volunteers. Harmine 146-155 monoamine oxidase A Homo sapiens 56-61 20810002-7 2011 MAOA binding was measured with [11C]harmine positron emission tomography (PET) in prefrontal brain regions and personality traits were measured with the NEO Personality Inventory Revised (NEO PI-R). Harmine 36-43 monoamine oxidase A Homo sapiens 0-4 17088501-8 2006 MAIN OUTCOME MEASURE: Harmine labeled with carbon 11, a radioligand selective for MAO-A and positron emission tomography, was used to measure MAO-A DVS (specific distribution volume), an index of MAO-A density, in different brain regions (prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex, caudate, putamen, thalamus, anterior temporal cortex, midbrain, hippocampus, and parahippocampus). Harmine 22-29 monoamine oxidase A Homo sapiens 82-87 21183355-1 2011 Previous studies have shown that harmine is a reversible inhibitor of human monoamine oxidase A (MAO-A). Harmine 33-40 monoamine oxidase A Homo sapiens 76-95 21183355-1 2011 Previous studies have shown that harmine is a reversible inhibitor of human monoamine oxidase A (MAO-A). Harmine 33-40 monoamine oxidase A Homo sapiens 97-102 21183355-2 2011 Moreover, the crystal structure of human MAO-A in complex with harmine has been recently solved. Harmine 63-70 monoamine oxidase A Homo sapiens 41-46 21183355-3 2011 This crystal structure shows that close to the methoxy group of the harmine moiety, a lipophilic pocket is left vacant within the binding site of human MAO-A. Harmine 68-75 monoamine oxidase A Homo sapiens 152-157 21183355-7 2011 The results show that O-alkylated compounds with lipophilic groups like cyclohexyl, phenyl and aliphatic chains increase the inhibition of MAO-A compared to harmine. Harmine 157-164 monoamine oxidase A Homo sapiens 139-144 20036304-8 2010 Inhibition of MAO-A by seed extracts was quantitatively attributed to harmaline and harmine whereas inhibition by root extracts came from harmine with no additional interferences. Harmine 84-91 monoamine oxidase A Homo sapiens 14-19 20219660-14 2010 Among various constituents of Banisteriopsis caapi, harmine (7), harmaline (6) and tetrahydroharmine (5) are responsible for MAO-A inhibition, while two major proanthocyanidines, epicatechin (8) and procyanidine B2 (9) produce antioxidant effects. Harmine 52-59 monoamine oxidase A Homo sapiens 125-130 17088501-8 2006 MAIN OUTCOME MEASURE: Harmine labeled with carbon 11, a radioligand selective for MAO-A and positron emission tomography, was used to measure MAO-A DVS (specific distribution volume), an index of MAO-A density, in different brain regions (prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex, caudate, putamen, thalamus, anterior temporal cortex, midbrain, hippocampus, and parahippocampus). Harmine 22-29 monoamine oxidase A Homo sapiens 142-147 17088501-8 2006 MAIN OUTCOME MEASURE: Harmine labeled with carbon 11, a radioligand selective for MAO-A and positron emission tomography, was used to measure MAO-A DVS (specific distribution volume), an index of MAO-A density, in different brain regions (prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex, caudate, putamen, thalamus, anterior temporal cortex, midbrain, hippocampus, and parahippocampus). Harmine 22-29 monoamine oxidase A Homo sapiens 142-147 12445480-5 2002 The inhibitors, D-amphetamine, harmine, tetrindole, and befloxatone all induce similar (but not identical) changes in the spectrum of MAO A, consistent with stacking of inhibitor with the flavin in the active site. Harmine 31-38 monoamine oxidase A Homo sapiens 134-139 16079787-0 2006 Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain. Harmine 53-60 monoamine oxidase A Homo sapiens 72-91 16079787-1 2006 This article describes the kinetic modeling of [(11)C]-harmine binding to monoamine oxidase A (MAO-A) binding sites in the human brain using positron emission tomography (PET). Harmine 55-62 monoamine oxidase A Homo sapiens 74-93 16079787-1 2006 This article describes the kinetic modeling of [(11)C]-harmine binding to monoamine oxidase A (MAO-A) binding sites in the human brain using positron emission tomography (PET). Harmine 55-62 monoamine oxidase A Homo sapiens 95-100 16079787-8 2006 Moclobemide treatment leads to a 64% to 79% MAO-A blockade across brain regions, a result that supports the specificity of [(11)C]-harmine binding to MAO-A. Harmine 131-138 monoamine oxidase A Homo sapiens 150-155 16149329-1 2005 Harmine, a major alkaloid in ayahuasca (hoasca), is a selective and reversible inhibitor of the enzyme monoamine oxidase-A (MAO-A). Harmine 0-7 monoamine oxidase A Homo sapiens 103-122 16149329-1 2005 Harmine, a major alkaloid in ayahuasca (hoasca), is a selective and reversible inhibitor of the enzyme monoamine oxidase-A (MAO-A). Harmine 0-7 monoamine oxidase A Homo sapiens 124-129 12445480-6 2002 D-Amphetamine, harmine, and tetrindole stabilise the semiquinone form of FAD during reduction of MAO A by dithionite and no further reduction of these inhibitor-MAO A complexes has been observed. Harmine 15-22 monoamine oxidase A Homo sapiens 97-102 10404423-2 1999 Such beverages are characterized by the presence of these three harmala alkaloids, where harmine and harmaline reversibly inhibit monoamine oxidase A (MAO-A) while tetrahydroharmine weakly inhibits the uptake of serotonin. Harmine 89-96 monoamine oxidase A Homo sapiens 130-149 10404423-2 1999 Such beverages are characterized by the presence of these three harmala alkaloids, where harmine and harmaline reversibly inhibit monoamine oxidase A (MAO-A) while tetrahydroharmine weakly inhibits the uptake of serotonin. Harmine 89-96 monoamine oxidase A Homo sapiens 151-156 9503561-4 1997 MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline. Harmine 80-87 monoamine oxidase A Homo sapiens 0-5 8990278-6 1997 Harmine, 2-methylharminium, 2,9-dimethylharminium, and harmaline were the most effective inhibitors of the purified MAO A, with low Ki values of 5, 69, 15, and 48 nM, respectively. Harmine 0-7 monoamine oxidase A Homo sapiens 116-121