PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33960660-7 2021 Inhibition of c-Fos or c-Jun (components of AP-1) both reversed the stimulatory effect of harmine on preosteoclast PDGF-BB production. Harmine 90-97 FBJ osteosarcoma oncogene Mus musculus 14-19 21047508-9 2011 In mechanistic studies, we found that harmine inhibited the RANKL-induced expression of c-Fos and subsequent expression of nuclear factor of activated T cells (NFAT) c1, which is a master regulator of osteoclastogenesis. Harmine 38-45 FBJ osteosarcoma oncogene Mus musculus 88-93 21047508-11 2011 These results indicate that harmine inhibits osteoclast formation via downregulation of c-Fos and NFATc1 induced by RANKL and represses bone resorption. Harmine 28-35 FBJ osteosarcoma oncogene Mus musculus 88-93