PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12649384-2	2003	Cytochromes P450 1A1 (18.5), 1A2 (20), and 2D6 (100) catalyzed the O-demethylation of harmaline, and CYP1A1 (98.5), CYP1A2 (35), CYP2C9 (16), CYP2C19 (30), and CYP2D6 (115) catalyzed that of harmine (relative activities).	Harmine	191-198	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	101-107	
23509697-0	2013	Harmine and harmaline downregulate TCDD-induced Cyp1a1 in the livers and lungs of C57BL/6 mice.	Harmine	0-7	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	48-54	
23509697-1	2013	We previously demonstrated that Peganum harmala L. extract and its main active constituents, harmine and harmaline inhibit the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated induction of the carcinogen-activating enzyme, Cyp1a1, in vitro.	Harmine	93-100	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	226-232	
23509697-3	2013	Therefore, the aim of this study is to examine the effect of harmine and harmaline on TCDD-mediated induction of Cyp1a1 in mice livers and lungs.	Harmine	61-68	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	113-119	
23509697-9	2013	The effect of harmine and harmaline on TCDD-mediated induction of Cyp1a1 mRNA, protein, and activity levels was determined using real-time PCR, Western blot analysis, and 7-ethoxyresurofin as a substrate, respectively.	Harmine	14-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	66-72	
23509697-10	2013	Our results showed that harmine and harmaline significantly decreased the TCDD-mediated induction of Cyp1a1 in both the livers and lungs.	Harmine	24-31	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	101-107	
23509697-11	2013	We concluded that harmine and harmaline are promising candidate to inhibit TCDD-mediated induction of Cyp1a1 in mice hepatic and extrahepatic tissues.	Harmine	18-25	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	102-108	
12649384-6	2003	Values for harmine were: CYP1A1, 45.2 and 52.2; CYP1A2, 9.2 and 14.7; CYP2C9, 11.9 and 117; CYP2C19, 21.4 and 121; and CYP2D6, 29.7 and 7.4.	Harmine	11-18	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	25-31