PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28871225-7	2017	However, when given MK571 and probenecid (the typical MRP2 inhibitor), the PappAB of harmine was increased (1.62- and 1.27-folds), and the efflux ratio was decreased from 1.59 to 0.98 and from 1.59 to 1.19, respectively.	Harmine	85-92	ATP binding cassette subfamily C member 2	Homo sapiens	54-58	
28871225-8	2017	In addition, the uptake ratio of harmine at 1 muM was >2.65 in the membrane vesicles expressing human MRP2.	Harmine	33-40	ATP binding cassette subfamily C member 2	Homo sapiens	105-109	
28871225-9	2017	Furthermore, harmine could slightly up-regulate the expression of MRP2, which implying harmine might be the substrate of MRP2.	Harmine	13-20	ATP binding cassette subfamily C member 2	Homo sapiens	66-70	
28871225-9	2017	Furthermore, harmine could slightly up-regulate the expression of MRP2, which implying harmine might be the substrate of MRP2.	Harmine	13-20	ATP binding cassette subfamily C member 2	Homo sapiens	121-125	
28871225-9	2017	Furthermore, harmine could slightly up-regulate the expression of MRP2, which implying harmine might be the substrate of MRP2.	Harmine	87-94	ATP binding cassette subfamily C member 2	Homo sapiens	66-70	
28871225-9	2017	Furthermore, harmine could slightly up-regulate the expression of MRP2, which implying harmine might be the substrate of MRP2.	Harmine	87-94	ATP binding cassette subfamily C member 2	Homo sapiens	121-125	
28871225-13	2017	MRP2 but MDR1 or BCRP might be involved in the transport of harmine.	Harmine	60-67	ATP binding cassette subfamily C member 2	Homo sapiens	0-4	
28871225-15	2017	All these findings suggested that harmine not only appears be an MRP2 substrate, but also possesses weak metabolic stability, and eventually leads to a low oral bioavailability.	Harmine	34-41	ATP binding cassette subfamily C member 2	Homo sapiens	65-69