PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33960660-5	2021	Exposure of RANKL-induced Primary bone marrow macrophages (BMMs), isolated from tibiae and femora of mice, to harmine increased the protein levels of Id2 and AP-1.	Harmine	110-117	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	12-17	
33960660-6	2021	Knockdown of Id2 by Id2-siRNA reduced the number of preosteoclasts as well as secretion of PDGF-BB in RANKL-stimulated BMMs administrated with harmine.	Harmine	143-150	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	102-107	
29721090-4	2018	METHODS: The impact of harmine on osteoclastogenesis of RANKL-stimulated RAW264.7 cells was verified by gene expression analysis and tartrate-resistant acid phosphatase (TRAP) staining.	Harmine	23-30	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	56-61	
29721090-11	2018	RESULTS: Exposure of RANKL-stimulated RAW264.7 cells to harmine enhanced the formation of preosteoclasts and the production of PDGF-BB.	Harmine	56-63	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	21-26	
29721090-12	2018	Harmine augmented the ability of RANKL-stimulated RAW264.7 cells to promote angiogenesis of endothelial cells, whereas the effect was blocked by PDGF-BB inhibition.	Harmine	0-7	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	33-38	
21047508-4	2011	We found that harmine, a beta-carboline alkaloid, inhibited multinucleated osteoclast formation induced by receptor activator of nuclear factor-kappaB ligand (RANKL) in RAW264.7 cells.	Harmine	14-21	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	107-157	
21047508-4	2011	We found that harmine, a beta-carboline alkaloid, inhibited multinucleated osteoclast formation induced by receptor activator of nuclear factor-kappaB ligand (RANKL) in RAW264.7 cells.	Harmine	14-21	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	159-164	
21047508-6	2011	Furthermore, harmine prevented RANKL-induced bone resorption in both cell and bone tissue cultures.	Harmine	13-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	31-36	
21047508-9	2011	In mechanistic studies, we found that harmine inhibited the RANKL-induced expression of c-Fos and subsequent expression of nuclear factor of activated T cells (NFAT) c1, which is a master regulator of osteoclastogenesis.	Harmine	38-45	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	60-65	
21047508-11	2011	These results indicate that harmine inhibits osteoclast formation via downregulation of c-Fos and NFATc1 induced by RANKL and represses bone resorption.	Harmine	28-35	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	116-121	
21504804-5	2011	Harmine promoted the dephosphorylation (activation) of NFATc1 in RAW264.7 cells within 24h, and it significantly increased the expression of NFATc1 in RAW264.7 cells and mouse primary bone marrow macrophages (BMMs) both in the presence and absence of RANKL stimulation.	Harmine	0-7	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	251-256