PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19421368-10	2009	However at higher concentrations (> 50 microM), daidzein only reduced IL-10 and IFN-gamma levels, whereas genistein reduced levels of the IL-2, IL-4, IL-10, IFN-gamma mRNA and protein and these results suggest that the Nano-soy supplementation improved immune response in SAMP8 mice which may be attributable to higher daidzin content in the black soybean preparation.	Genistein	109-118	interleukin 4	Mus musculus	147-151	
20599919-7	2010	Genistein also markedly attenuated the release of cytokines, including interleukin (IL)-2, IL-4, IL-5, interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha.	Genistein	0-9	interleukin 4	Mus musculus	91-95	
16815494-8	2006	Levels of OVA-specific IgG2a and IgG2b production and interleukin-4 production in response to OVA were not significantly different but tended to decrease in genistein-treated mice.	Genistein	157-166	interleukin 4	Mus musculus	54-67	
17190102-3	2006	The oral administration of 20 mg/kg genistein increased IFN-gamma and IL-4 production from DO11.10+ T cells in response to ovalbumin (OVA)323-339 peptide in female DO11.10 mice.	Genistein	36-45	interleukin 4	Mus musculus	70-74	
17087057-6	2006	In contrast, the production level of IL-4 in genistein-treated mice was not significantly different from that in control mice but tended to increase in a dose-dependent manner.	Genistein	45-54	interleukin 4	Mus musculus	37-41	
8757943-7	1996	In contrast to HMG-I(Y), IL-4 NAF/NF-IL-4 activation is refractory to rapamycin but sensitive to genistein.	Genistein	97-106	interleukin 4	Mus musculus	25-29	
16169028-4	2006	Biochanin A, genistein and p-ethylphenol significantly enhanced IL-4 production from both CD4(+) T cells and EL4 cells in a dose-dependent manner, while phenolic acid did not.	Genistein	13-22	interleukin 4	Mus musculus	64-68	
16169028-5	2006	Biochanin A, genistein and p-ethylphenol also enhanced IL-4 gene promoter activity in EL4 cells transiently transfected with IL-4 promoter constructs, but this effect was impaired in EL4 cells transfected with an IL-4 promoter construct deleted of a P4 site carrying NF-AT and AP-1 binding sites.	Genistein	13-22	interleukin 4	Mus musculus	55-59	
16169028-5	2006	Biochanin A, genistein and p-ethylphenol also enhanced IL-4 gene promoter activity in EL4 cells transiently transfected with IL-4 promoter constructs, but this effect was impaired in EL4 cells transfected with an IL-4 promoter construct deleted of a P4 site carrying NF-AT and AP-1 binding sites.	Genistein	13-22	interleukin 4	Mus musculus	125-129	
16169028-5	2006	Biochanin A, genistein and p-ethylphenol also enhanced IL-4 gene promoter activity in EL4 cells transiently transfected with IL-4 promoter constructs, but this effect was impaired in EL4 cells transfected with an IL-4 promoter construct deleted of a P4 site carrying NF-AT and AP-1 binding sites.	Genistein	13-22	interleukin 4	Mus musculus	125-129	
16169028-6	2006	In addition, biochanin A, genistein and p-ethylphenol increased both NF-AT and AP-1 DNA binding activities, indicating that they might enhance IL-4 production via NF-AT/AP-1 activation.	Genistein	26-35	interleukin 4	Mus musculus	143-147	
16169028-10	2006	These results demonstrate, for the first time, that biochanin A, genistein and p-ethylphenol enhance IL-4 production in activated T cells by two independent pathways, PI3-K/PKC/NF-AT and PKC/p38 MAPK/AP-1.	Genistein	65-74	interleukin 4	Mus musculus	101-105	
8757943-7	1996	In contrast to HMG-I(Y), IL-4 NAF/NF-IL-4 activation is refractory to rapamycin but sensitive to genistein.	Genistein	97-106	interleukin 4	Mus musculus	37-41	
28160073-7	2017	The activity of NF-kappaB signaling declined sharply after the treatment with genistein, as evidenced by the inhibition of NF-kappaB-p65, phospho-NF-kappaB-p65, and phospo-IkappaB-alpha expressions, as well as the expression of IkappaB-alpha and the messenger RNA (mRNA) expression of inflammatory cytokines (MCP1, TNFalpha, IL1beta, IL4, IL10) mediated by NF-kappaB signaling pathways in the early phase of the infection.	Genistein	78-87	interleukin 4	Mus musculus	334-337