PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35578172-0 2022 Molecular docking analysis reveals the functional inhibitory effect of Genistein and Quercetin on TMPRSS2: SARS-COV-2 cell entry facilitator spike protein. Genistein 71-80 transmembrane serine protease 2 Homo sapiens 98-105 35578172-6 2022 RESULTS: Docking analysis using PyRx version 0.8 along with AutoDockVina reveals that among the screened phyto compounds, Genistein shows the maximum binding affinity towards the hydrophobic substrate-binding site of TMPRSS2 with three hydrogen bonds interaction ( - 7.5 kcal/mol). Genistein 122-131 transmembrane serine protease 2 Homo sapiens 217-224 35578172-10 2022 CONCLUSION: The compounds, Quercetin and Genistein, can inhibit the TMPRSS2 guided priming of the spike protein. Genistein 41-50 transmembrane serine protease 2 Homo sapiens 68-75 35578172-12 2022 The critical finding is that compared to Genistein, Quercetin exhibits higher binding affinity with the catalytic unit of TMPRSS2 and forms a stable complex with the target. Genistein 41-50 transmembrane serine protease 2 Homo sapiens 122-129