PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32345540-4	2020	Mild HHcy was induced in ApoE-/- mice receiving a high-methionine diet.	Methionine	55-65	apolipoprotein E	Mus musculus	25-29	
26606905-0	2015	High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice.	Methionine	5-15	apolipoprotein E	Mus musculus	112-116	
28472596-3	2017	In the aorta of ApoE-/- mice fed a high methionine diet, increased expression of miR-148a/152, with decreased DNMT1 mRNA and protein levels, was detected.	Methionine	40-50	apolipoprotein E	Mus musculus	16-20	
28188730-0	2017	Involvement of histone methylation in macrophage apoptosis and unstable plaque formation in methionine-induced hyperhomocysteinemic ApoE-/- mice.	Methionine	92-102	apolipoprotein E	Mus musculus	132-136	
28188730-12	2017	Histone methylation might be involved in macrophage apoptosis and unstable plaque formation in methionine induced hyperhomocysteinemic ApoE-/- mice.	Methionine	95-105	apolipoprotein E	Mus musculus	135-139	
26956896-4	2016	In the present study, ApoE-/- mice were administrated methionine or atorvastatin, and were sacrificed after 2 months.	Methionine	54-64	apolipoprotein E	Mus musculus	22-26	
27936205-4	2016	The levels of EZH2 and H3K27me3 were increased in the aorta of ApoE-/- mice fed a high-methionine diet for 16 weeks, whereas miR-92a expression was decreased.	Methionine	87-97	apolipoprotein E	Mus musculus	63-67	
19776495-7	2009	RESULTS: Our data demonstrated that ApoE-/- mice fed a high methionine diet generated Hhcy, which subsequently increased the atherosclerotic lesion size significantly, promoted oxidative stress-associated DNA damage and PARP activation, then increased the expression of proinflammatory fac-tors within atherosclerotic plaques.	Methionine	60-70	apolipoprotein E	Mus musculus	36-40	
23593564-5	2013	Compared with the control group, atherosclerotic lesions in ApoE(-/-) mice fed a high methionine diet significantly increased, as did the expression of MCP-1.	Methionine	86-96	apolipoprotein E	Mus musculus	60-64	
23017835-3	2012	ApoE(-/-) mice were fed with high cholesterol and methionine diet for 15 weeks to induce hyperlipidemia and hyperhomocysteinemia.	Methionine	50-60	apolipoprotein E	Mus musculus	0-4	
19298207-0	2009	Methionine-induced hyperhomocysteinemia modulates lipoprotein profile and oxidative stress but not progression of atherosclerosis in aged apolipoprotein E knockout mice.	Methionine	0-10	apolipoprotein E	Mus musculus	138-154	
19261978-12	2008	We also observed increased immunohistochemical staining for N-Hcy-protein in aortic lesions from ApoE-deficient mice with hyperhomocysteinemia induced by a high methionine diet, relative to the mice fed a normal chow diet.	Methionine	161-171	apolipoprotein E	Mus musculus	97-101	
1512507-2	1992	The findings of the present study demonstrate that: a) as determined by density gradient ultracentrifugation and gel filtration chromatography, about 20% of the secreted [35S]methionine-labeled apoE expressed by C127E cells is lipid-associated.	Methionine	175-185	apolipoprotein E	Mus musculus	194-198	
18501553-6	2008	We also observed increased immunohistochemical staining for N-Hcy-proteins in aortic lesions from ApoE-/- mice with hyperhomocysteinemia induced by a high methionine diet, relative to ApoE-/- mice fed a control chow diet.	Methionine	155-165	apolipoprotein E	Mus musculus	98-102	
16876491-10	2006	In this study, post-translationally modified apolipoproteins, involving loss of amino acids from both the N- and C-termini, oxidation of methionine residues and possible acylation, were noted following reverse-phase separation.	Methionine	137-147	apolipoprotein E	Mus musculus	45-60	
16876491-11	2006	Further analyses by tandem mass spectrometry (MSMS) done on the tryptic digests of apolipoproteins separated by reverse phase chromatography enabled us to confirm sequence differences between the two strains, to verify selected apoA-I sequences that had been entered into the GenBank and to identify which methionines in apoA-I, apoC-III and apoE had been converted to methionine sulfoxides.	Methionine	306-317	apolipoprotein E	Mus musculus	83-98	
16910166-3	2006	Herein, we examined the influence of ApoE and folate deficiency on expression and activity of several enzymes of the methionine cycle.	Methionine	117-127	apolipoprotein E	Mus musculus	37-41	
11254667-2	2001	Here we show that induction of HHcy in apoE-null mice by a diet enriched in methionine but depleted in folate and vitamins B6 and B12 increased atherosclerotic lesion area and complexity, and enhanced expression of receptor for advanced glycation end products (RAGE), VCAM-1, tissue factor, and MMP-9 in the vasculature.	Methionine	76-86	apolipoprotein E	Mus musculus	39-43	
1512507-7	1992	c) Expression of apoE by C127E cells was associated with an increased release of [35S]methionine-labeled protein and [3H]glycerol-labeled lipid (3- to 5- and 4- to 8-fold, respectively) compared to nontransfected C127 cells.	Methionine	86-96	apolipoprotein E	Mus musculus	17-21