PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12021520-2 2002 methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients. Methionine 101-111 Cbl proto-oncogene Homo sapiens 20-23 7694037-1 1993 Homocysteine and 5-CH3-tetrahydrofolate (5-CH3-THF) are converted to methionine and THF by the CH3-cobalamin (CH3-Cbl)-dependent enzyme methionine synthase. Methionine 69-79 Cbl proto-oncogene Homo sapiens 114-117 7901104-3 1993 The latter requires CH3-Cbl and catalyzes the conversion of 5-CH3-tetrahydrofolate and homocysteine to tetrahydrofolate and methionine, respectively. Methionine 124-134 Cbl proto-oncogene Homo sapiens 24-27 7694037-11 1993 In patients with cbl C and cbl D mutations, methionine levels remained low or low-normal at 8.3 to 15.6 mumol/L (normal, 13.3 to 42.7) despite betaine treatment. Methionine 44-54 Cbl proto-oncogene Homo sapiens 17-20 7694037-11 1993 In patients with cbl C and cbl D mutations, methionine levels remained low or low-normal at 8.3 to 15.6 mumol/L (normal, 13.3 to 42.7) despite betaine treatment. Methionine 44-54 Cbl proto-oncogene Homo sapiens 27-30 34998158-0 2022 The CBL-LSD1-CXCL8 axis regulates methionine metabolism in glioma. Methionine 34-44 Cbl proto-oncogene Homo sapiens 4-7 34998158-10 2022 Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment. Methionine 119-129 Cbl proto-oncogene Homo sapiens 49-52 20352340-2 2010 TC deficiency is a rare autosomal recessive disorder causing intracellular Cbl depletion, which in turn causes megaloblastic bone marrow failure, accumulation of homocysteine and methylmalonic acid, and methionine depletion. Methionine 203-213 Cbl proto-oncogene Homo sapiens 75-78 30693532-4 2019 Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor. Methionine 90-100 Cbl proto-oncogene Homo sapiens 41-44 30693532-4 2019 Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor. Methionine 112-122 Cbl proto-oncogene Homo sapiens 41-44 30693532-8 2019 It also provides a description of folate-mediated one-carbon metabolism and its intersection with Cbl at the methionine cycle. Methionine 109-119 Cbl proto-oncogene Homo sapiens 98-101 23415654-1 2013 Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAM), which is involved in epigenomic regulatory mechanisms. Methionine 46-56 Cbl proto-oncogene Homo sapiens 24-27 32289469-2 2020 The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl). Methionine 28-38 Cbl proto-oncogene Homo sapiens 210-213