PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34015958-8 2022 The COMT polymorphism (methionine homozygous vs. valine carriers) was determined using single nucleotide polymorphism. Methionine 23-33 catechol-O-methyltransferase Homo sapiens 4-8 34015958-10 2022 Furthermore, individuals with the COMT methionine homozygous had higher FA and lower MD, RD, AD, and Cs values in the right rostral cingulum compared to the valine carriers across the entire adult life span. Methionine 39-49 catechol-O-methyltransferase Homo sapiens 34-38 30211780-2 2019 A widely studied COMT single nucleotide polymorphism (rs4680) changes the translated amino acid from valine to methionine (Val158Met); the polymorphism has been shown to influence opioid use. Methionine 111-121 catechol-O-methyltransferase Homo sapiens 17-21 30624689-5 2019 Pharmacogenetic effects of common COMT rs4680 (val158met), which encodes a nonsynonymous valine-to-methionine substitution, were examined in the trial plus a 10-year post-trial follow-up (overall) period of The Women"s Genome Health Study (WGHS, N = 23 294), a 10-year alpha-tocopherol and aspirin trial with 10 years post-trial follow-up. Methionine 99-109 catechol-O-methyltransferase Homo sapiens 34-38 33909692-0 2021 Fear of pain moderates the relationship between self-reported fatigue and methionine allele of catechol-O-methyltransferase gene in patients with fibromyalgia. Methionine 74-84 catechol-O-methyltransferase Homo sapiens 95-123 33124661-2 2021 The COMT gene polymorphism with methionine (Met) at codon 158 results in more dopamine (DA) in PFC and generally better EFs, while with valine (Val) at codon 158 the result is less PFC DA and generally poorer EFs. Methionine 32-42 catechol-O-methyltransferase Homo sapiens 4-8 33124661-2 2021 The COMT gene polymorphism with methionine (Met) at codon 158 results in more dopamine (DA) in PFC and generally better EFs, while with valine (Val) at codon 158 the result is less PFC DA and generally poorer EFs. Methionine 44-47 catechol-O-methyltransferase Homo sapiens 4-8 29594134-1 2018 Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Methionine 152-162 catechol-O-methyltransferase Homo sapiens 16-44 29426301-10 2018 The COMT genotypes were distributed as follows: Val/Met 48.7%, Met/Met 29.3%, Val/Val 21.3%. Methionine 52-55 catechol-O-methyltransferase Homo sapiens 4-8 29594134-1 2018 Background: The catechol-O-methyltransferase (COMT) Val158Met gene influences cognition and behavior in psychiatric illnesses; its low-activity allele, methionine (Met), may be associated with behavior reflecting catecholamine overactivity. Methionine 152-162 catechol-O-methyltransferase Homo sapiens 46-50 26450530-13 2016 However, the preeclamptic patients had elevated homocysteine levels that correlated inversely with 2-ME, indicating that an altered methionine-homocysteine metabolism may contribute to reduce COMT activity in vivo and explain the decreased levels of 2-ME in preeclamptic women. Methionine 132-142 catechol-O-methyltransferase Homo sapiens 192-196 29198511-8 2017 RESULTS: 1 COMT gene-linked locus that was associated with PE symptoms in the present study, rs4680, is a well-documented functional polymorphism that causes a valine-to-methionine substitution. Methionine 170-180 catechol-O-methyltransferase Homo sapiens 11-15 27780702-5 2017 OBJECTIVE: The methionine-containing catechol-O-methyltransferase protein coded by the L allele results in elevated catecholamine levels, reduced inactivation of the dopaminergic and adrenergic systems, and increased sensitivity to pain. Methionine 15-25 catechol-O-methyltransferase Homo sapiens 37-65 27458023-2 2017 In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity. Methionine 217-227 catechol-O-methyltransferase Homo sapiens 179-183 27458023-2 2017 In support of this notion, rich evidence has documented that the severity of various BD and schizophrenia symptoms is moderated by rs4680, a single nucleotide polymorphism of the COMT gene featuring a valine (Val)-to-methionine (Met) substitution that results in lower catalytic activity. Methionine 229-232 catechol-O-methyltransferase Homo sapiens 179-183 27939670-6 2017 The catfish Comt shared conserved putative structural regions important for S-adenosyl methionine (AdoMet)- and catechol-binding, transmembrane regions, two glycosylation sites (N-65 and N-91) at the N-terminus and two phosphorylation sites (Ser-235 and Thr-240) at the C-terminus. Methionine 87-97 catechol-O-methyltransferase Homo sapiens 12-16 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Methionine 246-256 catechol-O-methyltransferase Homo sapiens 4-32 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Methionine 246-256 catechol-O-methyltransferase Homo sapiens 34-38 26549298-1 2016 The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism (SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val (valine) allele resulting in 40% greater enzymatic activity than the Met (methionine) allele. Methionine 246-256 catechol-O-methyltransferase Homo sapiens 120-124 25253063-6 2015 The functional COMT Val158Met polymorphism of the COMT gene represents two coding variants, valine and methionine. Methionine 103-113 catechol-O-methyltransferase Homo sapiens 15-19 25640985-2 2015 The best characterized single nucleotide polymorphism (SNP) of the COMT gene consists of a valine (Val)-to-methionine (Met) substitution at codon 108/158. Methionine 107-117 catechol-O-methyltransferase Homo sapiens 67-71 25640985-2 2015 The best characterized single nucleotide polymorphism (SNP) of the COMT gene consists of a valine (Val)-to-methionine (Met) substitution at codon 108/158. Methionine 119-122 catechol-O-methyltransferase Homo sapiens 67-71 26251232-1 2015 Numerous studies demonstrate that the Methionine variant of the catechol-O-methyltransferase Val158Met polymorphism, which confers less efficient catabolism of catecholamines, is associated with increased focal activation of prefrontal cortex (PFC) and higher levels of executive function abilities. Methionine 38-48 catechol-O-methyltransferase Homo sapiens 64-92 26489634-3 2015 This study aimed to examine the association of the genotypes of ABCB1 C3435T, OPRM1 A118G and COMT V108/158M (valine 108/158 methionine) with pain perception in cancer patients. Methionine 125-135 catechol-O-methyltransferase Homo sapiens 94-98 25466290-3 2015 The activity of COMT enzyme is genetically polymorphic due to a guanine-to-adenine transition at codon 158, resulting in a valine (Val) to methionine (Met) substitution. Methionine 139-149 catechol-O-methyltransferase Homo sapiens 16-20 25466290-3 2015 The activity of COMT enzyme is genetically polymorphic due to a guanine-to-adenine transition at codon 158, resulting in a valine (Val) to methionine (Met) substitution. Methionine 151-154 catechol-O-methyltransferase Homo sapiens 16-20 25253063-6 2015 The functional COMT Val158Met polymorphism of the COMT gene represents two coding variants, valine and methionine. Methionine 103-113 catechol-O-methyltransferase Homo sapiens 50-54 26630958-5 2015 The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. Methionine 77-87 catechol-O-methyltransferase Homo sapiens 44-48 24118473-2 2015 Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. Methionine 185-195 catechol-O-methyltransferase Homo sapiens 76-109 24118473-2 2015 Several studies and recent meta-analyses indicate that in schizophrenia the catecholamine-O-methyltransferase (COMT) Val158Met genotype may be associated with aggression, most often in methionine allele carriers. Methionine 185-195 catechol-O-methyltransferase Homo sapiens 111-115 26630958-5 2015 The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158. Methionine 77-80 catechol-O-methyltransferase Homo sapiens 44-48 24956262-2 2014 Current evidence suggests that the val/met single nucleotide polymorphism in the COMT gene can predict the efficiency of executive cognition in humans. Methionine 39-42 catechol-O-methyltransferase Homo sapiens 81-85 24888672-2 2014 A functional valine-to-methionine (Val158Met) polymorphism in the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of schizophrenia despite weak or no association with the disorder itself. Methionine 22-33 catechol-O-methyltransferase Homo sapiens 66-94 24888672-2 2014 A functional valine-to-methionine (Val158Met) polymorphism in the catechol-O-methyltransferase (COMT) gene is shown to modify clinical presentation of schizophrenia despite weak or no association with the disorder itself. Methionine 22-33 catechol-O-methyltransferase Homo sapiens 96-100 25035343-4 2014 APPROACH AND RESULTS: We examined COMT polymorphism rs4680 (MAF [minor allele frequency], 0.47), encoding a nonsynonymous methionine-to-valine substitution, in the Women"s Genome Health Study (WGHS), a large population-based cohort of women with randomized allocation to aspirin or vitamin E when compared with placebo and 10-year follow-up. Methionine 122-132 catechol-O-methyltransferase Homo sapiens 34-38 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Methionine 22-32 catechol-O-methyltransferase Homo sapiens 103-131 25029900-3 2014 Compared to the valine (Val) allele, the methionine (Met) allele of the COMT gene has been linked to superior executive function, but it is not known whether it is associated with training-related effects in multi-UV supervisory control performance. Methionine 41-51 catechol-O-methyltransferase Homo sapiens 72-76 25029900-3 2014 Compared to the valine (Val) allele, the methionine (Met) allele of the COMT gene has been linked to superior executive function, but it is not known whether it is associated with training-related effects in multi-UV supervisory control performance. Methionine 53-56 catechol-O-methyltransferase Homo sapiens 72-76 24956006-2 2014 Studies have linked common polymorphisms (valine to methionine substitution; VAL/MET) in the catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) to cognitive differences between individuals. Methionine 52-62 catechol-O-methyltransferase Homo sapiens 93-121 24956006-2 2014 Studies have linked common polymorphisms (valine to methionine substitution; VAL/MET) in the catechol-O-methyltransferase (COMT) and brain-derived neurotrophic factor (BDNF) to cognitive differences between individuals. Methionine 52-62 catechol-O-methyltransferase Homo sapiens 123-127 24225542-4 2014 Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. Methionine 44-54 catechol-O-methyltransferase Homo sapiens 39-43 24225542-4 2014 Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. Methionine 44-54 catechol-O-methyltransferase Homo sapiens 90-94 24225542-4 2014 Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. Methionine 44-47 catechol-O-methyltransferase Homo sapiens 39-43 24225542-4 2014 Individuals who are homozygous for the COMT methionine (met) allele show reduced cortical COMT enzymatic activity, resulting in increased dopamine levels in the prefrontal cortex as opposed to individuals who are carriers of the valine (val) allele. Methionine 44-47 catechol-O-methyltransferase Homo sapiens 90-94 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Methionine 22-32 catechol-O-methyltransferase Homo sapiens 133-137 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Methionine 22-25 catechol-O-methyltransferase Homo sapiens 103-131 23828159-1 2013 RATIONALE: The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers. Methionine 22-25 catechol-O-methyltransferase Homo sapiens 133-137 23686330-6 2013 The APS haplotype contains an adenine corresponding to methionine, instead of valine, at position 158 of the COMT protein. Methionine 55-65 catechol-O-methyltransferase Homo sapiens 109-113 24039968-2 2013 Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met). Methionine 195-205 catechol-O-methyltransferase Homo sapiens 271-275 24039968-2 2013 Nonetheless, until this moment, few studies addressed the relationship between different types of impulsivity and the single nucleotide polymorphism caused by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met). Methionine 195-198 catechol-O-methyltransferase Homo sapiens 271-275 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Methionine 155-165 catechol-O-methyltransferase Homo sapiens 55-83 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Methionine 155-165 catechol-O-methyltransferase Homo sapiens 85-89 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Methionine 167-170 catechol-O-methyltransferase Homo sapiens 55-83 23818048-3 2013 The single nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase (COMT) gene results in an amino acid substitution from valine (Val) to methionine (Met). Methionine 167-170 catechol-O-methyltransferase Homo sapiens 85-89 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Methionine 127-137 catechol-O-methyltransferase Homo sapiens 0-28 23535252-4 2013 Catechol-O-methyltransferase (COMT), a key dopamine regulator in the brain, contains a co-dominant allele in which a valine-to-methionine substitution causes variations in enzymatic activity leading to reduced synaptic dopamine levels in the Val/Val genotype. Methionine 127-137 catechol-O-methyltransferase Homo sapiens 30-34 23278923-4 2013 In particular, we found that the COMT Val/Met polymorphism at rs4680, which results in the substitution of the ancestral Valine (Val) by Methionine (Met), was associated with better performance on a number of critical reading measures and with patterns of functional neural activation that have been linked to better readers. Methionine 137-147 catechol-O-methyltransferase Homo sapiens 33-37 22901597-6 2013 RESULTS: An effect of COMT on perceived distress subscale has been shown, with methionine (Met)/Met subjects reporting lower rates of stress compared with Val/Val. Methionine 79-89 catechol-O-methyltransferase Homo sapiens 22-26 23278923-4 2013 In particular, we found that the COMT Val/Met polymorphism at rs4680, which results in the substitution of the ancestral Valine (Val) by Methionine (Met), was associated with better performance on a number of critical reading measures and with patterns of functional neural activation that have been linked to better readers. Methionine 42-45 catechol-O-methyltransferase Homo sapiens 33-37 23110189-6 2012 In a regression model, the number of methionine alleles in COMT val158met was linearly related to placebo response as measured by changes in IBS-SSS (p = .035). Methionine 37-47 catechol-O-methyltransferase Homo sapiens 59-63 22551521-9 2012 In S-adenosyl methionine- and GSH-supplemented human S9 incubations, M1-1 formation decreased by 80% but increased after tolcapone-inhibited catechol-O-methyltransferase (COMT) activity. Methionine 14-24 catechol-O-methyltransferase Homo sapiens 171-175 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Methionine 133-143 catechol-O-methyltransferase Homo sapiens 29-33 21860037-7 2011 Methionine (Met)/Met homozygote schizophrenia patients show 4- to 5-fold lower COMT activity than valine (Val)/Val homozygotes, and some but not all studies have found an association with aggression and violence. Methionine 0-10 catechol-O-methyltransferase Homo sapiens 79-83 21860037-7 2011 Methionine (Met)/Met homozygote schizophrenia patients show 4- to 5-fold lower COMT activity than valine (Val)/Val homozygotes, and some but not all studies have found an association with aggression and violence. Methionine 0-3 catechol-O-methyltransferase Homo sapiens 79-83 21486391-2 2011 It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. Methionine 134-144 catechol-O-methyltransferase Homo sapiens 168-172 21486391-2 2011 It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. Methionine 146-149 catechol-O-methyltransferase Homo sapiens 168-172 22399090-4 2011 We observed a significant interaction effect between the 10-repeat (10R) allele of the dopamine transporter (DAT1) gene and the methionine (Met) allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism (F((1,1018)) = 11.11; P < 0.001). Methionine 128-138 catechol-O-methyltransferase Homo sapiens 159-187 22399090-4 2011 We observed a significant interaction effect between the 10-repeat (10R) allele of the dopamine transporter (DAT1) gene and the methionine (Met) allele of the catechol-O-methyltransferase (COMT) Val158Met polymorphism (F((1,1018)) = 11.11; P < 0.001). Methionine 128-138 catechol-O-methyltransferase Homo sapiens 189-193 21575337-1 2011 OBJECTIVE: To investigate the association between aggressive behaviors and catechol-O-methyltransferase (COMT) single nucleotide polymorphism at position 158 from a valine to a methionine (Val158Met) as well as serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) in children. Methionine 177-187 catechol-O-methyltransferase Homo sapiens 75-103 21575337-1 2011 OBJECTIVE: To investigate the association between aggressive behaviors and catechol-O-methyltransferase (COMT) single nucleotide polymorphism at position 158 from a valine to a methionine (Val158Met) as well as serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) in children. Methionine 177-187 catechol-O-methyltransferase Homo sapiens 105-109 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Methionine 133-143 catechol-O-methyltransferase Homo sapiens 57-61 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Methionine 133-143 catechol-O-methyltransferase Homo sapiens 57-61 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Methionine 44-47 catechol-O-methyltransferase Homo sapiens 29-33 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Methionine 44-47 catechol-O-methyltransferase Homo sapiens 57-61 20860878-5 2011 The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. Methionine 44-47 catechol-O-methyltransferase Homo sapiens 57-61 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Methionine 95-105 catechol-O-methyltransferase Homo sapiens 13-41 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Methionine 95-105 catechol-O-methyltransferase Homo sapiens 43-47 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Methionine 58-61 catechol-O-methyltransferase Homo sapiens 13-41 21648315-1 2011 A functional catechol-o-methyltransferase (COMT Val158/108Met) polymorphism, a valine (Val) to methionine (Met) substitution, has been associated with cognitive processing in the normal brain, older age, mild cognitive impairment and in various dementias. Methionine 58-61 catechol-O-methyltransferase Homo sapiens 43-47 20038544-2 2010 Because of the established role of the dopaminergic system in the neural encoding of rewards and negative events, we investigated young healthy volunteers being homozygous for either the Valine or Methionine variant of the catechol-O-methyltransferase (COMT) codon 158 polymorphism as well as homozygous for the C or T variant of the SNP -521 polymorphism of the dopamine D4 receptor. Methionine 197-207 catechol-O-methyltransferase Homo sapiens 223-251 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Methionine 118-128 catechol-O-methyltransferase Homo sapiens 4-32 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Methionine 118-128 catechol-O-methyltransferase Homo sapiens 34-38 20184941-1 2010 The catechol-O-methyltransferase (COMT) val(158)met polymorphism, which codes for the substitution of valine (val) by methionine (met) leading to a reduced COMT activity in homo- or heterozygous individuals, is associated with individual pain sensitivity and dopaminergic responses in Parkinson"s disease as well as with various chronic painful diseases. Methionine 118-128 catechol-O-methyltransferase Homo sapiens 156-160 19946713-2 2010 A single nucleotide polymorphism (Val(158)Met SNP, rs4680) leads to either methionine (Met) or valine (Val) at codon 158, resulting in a three- to fourfold reduction in COMT activity. Methionine 75-85 catechol-O-methyltransferase Homo sapiens 169-173 20210499-4 2010 A significant effect of the COMT valine(1)methionine (Val 158 Met) polymorphism was found. Methionine 42-52 catechol-O-methyltransferase Homo sapiens 28-32 19892319-0 2010 Catechol-o-methyltransferase valine(158)methionine genotype and resting regional cerebral blood flow in medication-free patients with schizophrenia. Methionine 40-50 catechol-O-methyltransferase Homo sapiens 0-28 19892319-1 2010 BACKGROUND: A valine(158)methionine (val(158)met) polymorphism in catechol-O-methyltransferase (COMT) modulates cortical dopaminergic catabolism and has been associated with schizophrenia. Methionine 25-35 catechol-O-methyltransferase Homo sapiens 66-94 19892319-1 2010 BACKGROUND: A valine(158)methionine (val(158)met) polymorphism in catechol-O-methyltransferase (COMT) modulates cortical dopaminergic catabolism and has been associated with schizophrenia. Methionine 25-35 catechol-O-methyltransferase Homo sapiens 96-100 19946713-2 2010 A single nucleotide polymorphism (Val(158)Met SNP, rs4680) leads to either methionine (Met) or valine (Val) at codon 158, resulting in a three- to fourfold reduction in COMT activity. Methionine 42-45 catechol-O-methyltransferase Homo sapiens 169-173 19605537-3 2009 A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks. Methionine 22-33 catechol-O-methyltransferase Homo sapiens 68-96 19539269-0 2009 Catechol-O-methyltransferase valine(158)methionine polymorphism modulates brain networks underlying working memory across adulthood. Methionine 40-50 catechol-O-methyltransferase Homo sapiens 0-28 19539269-3 2009 Among these variations, those related to the dopaminergic system, particularly the valine(158)methionine polymorphism in catechol-O-methyltransferase (COMTval(158)met), have been implicated in modulating age-related changes in executive function. Methionine 94-104 catechol-O-methyltransferase Homo sapiens 121-149 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Methionine 185-195 catechol-O-methyltransferase Homo sapiens 47-75 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Methionine 185-195 catechol-O-methyltransferase Homo sapiens 77-81 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Methionine 185-195 catechol-O-methyltransferase Homo sapiens 235-239 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Methionine 197-200 catechol-O-methyltransferase Homo sapiens 47-75 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Methionine 197-200 catechol-O-methyltransferase Homo sapiens 77-81 19726643-2 2009 A functional polymorphism in the gene encoding catechol-O-methyltransferase (COMT), an enzyme playing an important role in cortical dopamine metabolism, causes a common substitution of methionine (Met) for valine (Val) at codon 158 of COMT protein. Methionine 197-200 catechol-O-methyltransferase Homo sapiens 235-239 19278671-3 2009 The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Methionine 122-132 catechol-O-methyltransferase Homo sapiens 69-97 19278671-3 2009 The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Methionine 122-132 catechol-O-methyltransferase Homo sapiens 99-103 19278671-3 2009 The present investigation examined for the first time the effects of catechol-O-methyltransferase (COMT) valine (val) 158 methionine (met) (val158met) polymorphism, which has been shown to moderate predisposition to negative mood and affective disorders, on brain structure and function in children. Methionine 80-83 catechol-O-methyltransferase Homo sapiens 99-103 21095459-0 2010 Catechol-O-methyltransferase enzyme: cofactor S-adenosyl-L-methionine and related mechanisms. Methionine 56-69 catechol-O-methyltransferase Homo sapiens 0-28 19605537-3 2009 A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks. Methionine 22-33 catechol-O-methyltransferase Homo sapiens 98-102 19246329-3 2009 A common polymorphism with valine to methionine substitution alters COMT activity that results in higher enzyme activity in the valine variant. Methionine 37-47 catechol-O-methyltransferase Homo sapiens 68-72 19251248-7 2009 CONCLUSIONS: The results demonstrate the role of the COMT Val/Met polymorphism in the processing of reward, consistent with theoretical explanations that suggest the possible role of dopamine in the MFN and beta power increase generation. Methionine 62-65 catechol-O-methyltransferase Homo sapiens 53-57 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Methionine 183-193 catechol-O-methyltransferase Homo sapiens 0-29 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Methionine 183-193 catechol-O-methyltransferase Homo sapiens 31-35 19023276-2 2009 Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. Methionine 183-193 catechol-O-methyltransferase Homo sapiens 119-123 20037207-3 2009 The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. Methionine 139-149 catechol-O-methyltransferase Homo sapiens 205-209 20037207-3 2009 The substitution of leucine (Leu) to valine (Val) at codon 432 increases the catalytic activity of CYP1B1, however, substitution of Val to methionine (Met) at codon 158 decreases the catalytic activity of COMT. Methionine 151-154 catechol-O-methyltransferase Homo sapiens 205-209 18545092-0 2008 Val/Met polymorphism of the COMT gene moderates the association between job strain and early atherosclerosis in young men. Methionine 4-7 catechol-O-methyltransferase Homo sapiens 28-32 18801628-2 2008 Polymorphic variants of genes encoding key enzymes of folate and methionine metabolism may have an impact on catecholamine catabolism conducted by catechol-O-methyltransferase. Methionine 65-75 catechol-O-methyltransferase Homo sapiens 147-175 18703939-3 2008 We investigated the association between the COMT valine (Val) 108/158 methionine (Met) polymorphism and the response to treatment with methylphenidate (MPH) in children with ADHD. Methionine 70-80 catechol-O-methyltransferase Homo sapiens 44-48 18703939-3 2008 We investigated the association between the COMT valine (Val) 108/158 methionine (Met) polymorphism and the response to treatment with methylphenidate (MPH) in children with ADHD. Methionine 82-85 catechol-O-methyltransferase Homo sapiens 44-48 18596619-1 2008 The methionine variant of Val66Met brain-derived neurotrophic factor BDNF met and catecholamine-O-methyltransferase (COMT L) is associated with a deficit in attention and aggravation of delusions in schizophrenia. Methionine 4-14 catechol-O-methyltransferase Homo sapiens 117-121 18474266-1 2008 The human gene for catechol O-methyltransferase has a common single-nucleotide polymorphism that results in substitution of methionine (M) for valine (V) 108 in the soluble form of the enzyme (s-COMT). Methionine 124-134 catechol-O-methyltransferase Homo sapiens 19-47 18474266-1 2008 The human gene for catechol O-methyltransferase has a common single-nucleotide polymorphism that results in substitution of methionine (M) for valine (V) 108 in the soluble form of the enzyme (s-COMT). Methionine 124-134 catechol-O-methyltransferase Homo sapiens 195-199 18820009-6 2008 Pairwise analysis showed that combinations of the ERalpha G allele with the homozygous Trp genotype of CYP19A1 codon 39 (rs2236722), the methionine (Met) allele of COMT codon 158 (rs4680) or Pro allele of p53 codon 72 (rs1042522) were more frequent in ER-positive than ER-negative breast cancer, especially in patients less than 50-year old. Methionine 137-147 catechol-O-methyltransferase Homo sapiens 164-168 18486144-4 2008 Additionally, human COMT contains a common valine-methionine polymorphism at position 108. Methionine 50-60 catechol-O-methyltransferase Homo sapiens 20-24 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Methionine 49-59 catechol-O-methyltransferase Homo sapiens 126-130 18250258-7 2008 RESULTS: We present replicated evidence that the COMT valine/methionine polymorphism at codon 158 (COMT Val158Met) was associated with phenotypic variation among children with ADHD. Methionine 61-71 catechol-O-methyltransferase Homo sapiens 49-53 18250258-7 2008 RESULTS: We present replicated evidence that the COMT valine/methionine polymorphism at codon 158 (COMT Val158Met) was associated with phenotypic variation among children with ADHD. Methionine 61-71 catechol-O-methyltransferase Homo sapiens 99-103 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Methionine 49-59 catechol-O-methyltransferase Homo sapiens 203-207 17980711-2 2008 The G to A polymorphism causes a valine (val) to methionine (met) substitution at codon 108 soluble - (S)/158 membrane - (MB)-COMT, generating alleles encoding high and low-activity forms of the enzyme, COMT H and COMT L, respectively. Methionine 49-59 catechol-O-methyltransferase Homo sapiens 203-207 17412710-5 2007 The ability to test the hypothesis that COMT might be a susceptibility gene for schizophrenia has been simplified in principle by the existence of a valine-to-methionine (Val/Met) polymorphism which results respectively in high and low activity forms of the enzyme. Methionine 175-178 catechol-O-methyltransferase Homo sapiens 40-44 17601704-1 2007 BACKGROUND: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. Methionine 21-31 catechol-O-methyltransferase Homo sapiens 52-80 17601704-1 2007 BACKGROUND: A valine/methionine polymorphism of the catechol O-methyltransferase gene at the nucleotide which encodes amino acid val or met at position 158 in the protein (COMT Val158Met polymorphism) has been associated with deficits in executive functioning in schizophrenia in some studies. Methionine 21-31 catechol-O-methyltransferase Homo sapiens 172-176 17913879-5 2007 The Val/Met polymorphism of the COMT gene, associated with prefrontal cortical dopamine function, predicted participants" ability to rapidly adapt behavior on a trial-to-trial basis. Methionine 8-11 catechol-O-methyltransferase Homo sapiens 32-36 17760745-3 2007 The enzymatic activity of COMT has been shown to be governed by a functional single-nucleotide polymorphism represented by a G-to-A transition at codon 158, that results in a valine to methionine substitution; this variant form is associated with an up to 4-fold decrease in enzymatic activity. Methionine 185-195 catechol-O-methyltransferase Homo sapiens 26-30 17548151-3 2007 Functional variation in the human COMT gene occurs at a single nucleotide polymorphism (SNP)--472G>A--that results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met). Methionine 139-149 catechol-O-methyltransferase Homo sapiens 34-38 17548151-3 2007 Functional variation in the human COMT gene occurs at a single nucleotide polymorphism (SNP)--472G>A--that results in a valine (Val) to methionine (Met) amino acid substitution (Val158Met). Methionine 151-154 catechol-O-methyltransferase Homo sapiens 34-38 17475791-6 2007 We scanned 31 patients with early PD who were homozygous for either valine (val) (n = 16) or methionine (met) (n = 15) at the COMT val(158)met polymorphism during performance of an executive task comprising both Tower of London (planning) and simple subtracting ("control") problems. Methionine 93-103 catechol-O-methyltransferase Homo sapiens 126-130 17475791-6 2007 We scanned 31 patients with early PD who were homozygous for either valine (val) (n = 16) or methionine (met) (n = 15) at the COMT val(158)met polymorphism during performance of an executive task comprising both Tower of London (planning) and simple subtracting ("control") problems. Methionine 93-96 catechol-O-methyltransferase Homo sapiens 126-130 16837108-1 2007 BACKGROUND: The gene encoding catechol-O-methyltransferase (COMT) has been suggested as a candidate for Alzheimer-related psychosis (AD-P) susceptibility, and an association between AD-P and a functional valine to methionine polymorphism has been reported. Methionine 214-224 catechol-O-methyltransferase Homo sapiens 30-58 16837108-1 2007 BACKGROUND: The gene encoding catechol-O-methyltransferase (COMT) has been suggested as a candidate for Alzheimer-related psychosis (AD-P) susceptibility, and an association between AD-P and a functional valine to methionine polymorphism has been reported. Methionine 214-224 catechol-O-methyltransferase Homo sapiens 60-64 16837108-4 2007 Four single-nucleotide polymorphisms (SNPs) within COMT gene were evaluated, i.e. rs737865, rs737864, intron 1 C2754delC, and the well-known valine/methionine variant (rs4680). Methionine 148-158 catechol-O-methyltransferase Homo sapiens 51-55 17464676-5 2007 Recent studies show that individuals with the homozygous COMT (valine/valine) genotype demonstrated improvement following psychostimulant treatment, because their tonic dopamine (DA) levels were low, whereas the homozygous COMT (methionine/methionine) individuals, who already have high initial prefrontal cortex (PFC) dopamine levels performed more poorly after medication, in tasks with high working memory load. Methionine 240-250 catechol-O-methyltransferase Homo sapiens 57-61 17464676-5 2007 Recent studies show that individuals with the homozygous COMT (valine/valine) genotype demonstrated improvement following psychostimulant treatment, because their tonic dopamine (DA) levels were low, whereas the homozygous COMT (methionine/methionine) individuals, who already have high initial prefrontal cortex (PFC) dopamine levels performed more poorly after medication, in tasks with high working memory load. Methionine 229-239 catechol-O-methyltransferase Homo sapiens 57-61 16897602-3 2007 A single-nucleotide polymorphism of COMT gene at position 108/158 results in an amino acid substitution from valine (val) to methionine (met), which modifies its enzymatic activity and may change the brain morphology and expressional behaviors. Methionine 125-135 catechol-O-methyltransferase Homo sapiens 36-40 16897602-3 2007 A single-nucleotide polymorphism of COMT gene at position 108/158 results in an amino acid substitution from valine (val) to methionine (met), which modifies its enzymatic activity and may change the brain morphology and expressional behaviors. Methionine 125-128 catechol-O-methyltransferase Homo sapiens 36-40 20223014-2 2006 The efficiency of this process varies due to a polymorphism in COMT, which changes valine to methionine (V158M). Methionine 93-103 catechol-O-methyltransferase Homo sapiens 63-67 16527884-3 2006 For the COMT gene, we selected the G/A nonsynonymous single-nucleotide polymorphism (SNP) that leads to valine-to-methionine (Val/Met) substitution. Methionine 130-133 catechol-O-methyltransferase Homo sapiens 8-12 16542182-3 2006 A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia. Methionine 9-19 catechol-O-methyltransferase Homo sapiens 40-68 16542182-3 2006 A valine/methionine polymorphism of the catechol O-methyltransferase gene at amino acid 158 (COMT Val158Met polymorphism) has been identified as a risk factor for cognitive impairment in schizophrenia. Methionine 9-19 catechol-O-methyltransferase Homo sapiens 93-97 15645182-3 2005 A coding polymorphism of the COMT gene at codon 108/158 (soluble/membrane-bound form) causing a valine to methionine substitution has been shown to influence enzyme activity, but its association with schizophrenia is inconclusive. Methionine 106-116 catechol-O-methyltransferase Homo sapiens 29-33 16135635-1 2005 OBJECTIVE: A valine/methionine polymorphism in the catechol O-methyltransferase (COMT) gene has been proposed to influence susceptibility to schizophrenia, as has a COMT haplotype in Ashkenazi Jewish and Irish subjects. Methionine 20-30 catechol-O-methyltransferase Homo sapiens 51-79 16135635-1 2005 OBJECTIVE: A valine/methionine polymorphism in the catechol O-methyltransferase (COMT) gene has been proposed to influence susceptibility to schizophrenia, as has a COMT haplotype in Ashkenazi Jewish and Irish subjects. Methionine 20-30 catechol-O-methyltransferase Homo sapiens 81-85 16135635-1 2005 OBJECTIVE: A valine/methionine polymorphism in the catechol O-methyltransferase (COMT) gene has been proposed to influence susceptibility to schizophrenia, as has a COMT haplotype in Ashkenazi Jewish and Irish subjects. Methionine 20-30 catechol-O-methyltransferase Homo sapiens 165-169 16475806-1 2006 The human gene for catechol O-methyltransferase (COMT) contains a common polymorphism that results in substitution of methionine (M) for valine (V) at residue 108 of the soluble form of the protein. Methionine 118-128 catechol-O-methyltransferase Homo sapiens 19-47 16475806-1 2006 The human gene for catechol O-methyltransferase (COMT) contains a common polymorphism that results in substitution of methionine (M) for valine (V) at residue 108 of the soluble form of the protein. Methionine 118-128 catechol-O-methyltransferase Homo sapiens 49-53 16275815-4 2005 Recent evidence suggests that prefrontal cortical function is influenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene. Methionine 85-95 catechol-O-methyltransferase Homo sapiens 111-139 16275815-4 2005 Recent evidence suggests that prefrontal cortical function is influenced by a valine/methionine variant in the catechol O-methyltransferase (COMT) gene. Methionine 85-95 catechol-O-methyltransferase Homo sapiens 141-145 15654584-0 2005 The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. Methionine 4-14 catechol-O-methyltransferase Homo sapiens 29-33 15654584-10 2005 COMT genotype, however, affected prefrontal cognition in ADHD: ADHD children who were homozygous for the valine variant had significantly better sustained attention than those ADHD children possessing at least one copy of the methionine variant. Methionine 226-236 catechol-O-methyltransferase Homo sapiens 0-4 15654584-12 2005 Contrary to expectations, the methionine variant of the Val158Met COMT gene polymorphism impaired prefrontally-mediated cognition in ADHD. Methionine 30-40 catechol-O-methyltransferase Homo sapiens 66-70 15654584-14 2005 Against this background, the slower clearance of dopamine associated with the methionine variant of the COMT gene polymorphism may be disadvantageous to cognition in ADHD. Methionine 78-88 catechol-O-methyltransferase Homo sapiens 104-108 15505638-2 2005 The interest in COMT as a candidate SZ risk factor has led to numerous case-control and family-based studies, with the majority placing emphasis on examining a functional Val/Met polymorphism within this enzyme. Methionine 175-178 catechol-O-methyltransferase Homo sapiens 16-20 15652872-1 2005 BACKGROUND: A common functional polymorphism (Val/Met) in the catechol-O-methyltransferase gene (COMT) that markedly affects enzyme activity has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans. Methionine 50-53 catechol-O-methyltransferase Homo sapiens 62-90 15652872-1 2005 BACKGROUND: A common functional polymorphism (Val/Met) in the catechol-O-methyltransferase gene (COMT) that markedly affects enzyme activity has been shown to affect executive cognition and the physiology of the prefrontal cortex in humans. Methionine 50-53 catechol-O-methyltransferase Homo sapiens 97-101 14706432-1 2004 BACKGROUND: A common polymorphism in the catechol-O-methyltransferase gene involves a valine to methionine mutation that results in a threefold to fourfold decrease in enzyme activity. Methionine 96-106 catechol-O-methyltransferase Homo sapiens 41-69 15261699-4 2004 We genotyped the valine/methionine polymorphism of codon 108/158 in the catechol-O-methyltransferase (COMT) gene, the 30-bp repeat polymorphism in the promoter of the monoamine oxidase A (MAOA) gene, and the A/G polymorphism in intron 13 of the monoamine oxidase B (MAOB) gene in 206 Japanese patients with schizophrenia. Methionine 24-34 catechol-O-methyltransferase Homo sapiens 72-100 15169701-4 2004 RESULTS: In the healthy siblings, a linear relationship was seen in which performance on the Wisconsin Card Sorting Test was associated in an allele dosage fashion with COMT genotype (i.e., fewer perseverative errors with higher number of methionine alleles). Methionine 239-249 catechol-O-methyltransferase Homo sapiens 169-173 12707935-2 2003 The molecular basis of COMT thermolability, that leads to three to fourfold differences in enzyme activity, is due to a substitution of valine with methionine in the Val158/108Met polymorphism. Methionine 148-158 catechol-O-methyltransferase Homo sapiens 23-27 8807664-3 1996 We now show that this is due to G-->A transition at codon 158 of the COMT gene that results in a valine to methionine substitution. Methionine 110-120 catechol-O-methyltransferase Homo sapiens 72-76 11693181-2 2001 A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane-bound COMT, respectively, whereby a G to A transition results in a valine to methionine substitution. Methionine 166-176 catechol-O-methyltransferase Homo sapiens 95-99 11223018-0 2001 COMT-dependent protection of dopaminergic neurons by methionine, dimethionine and S-adenosylmethionine (SAM) against L-dopa toxicity in vitro. Methionine 53-63 catechol-O-methyltransferase Homo sapiens 0-4 9682265-3 1998 A low activity allele has been demonstrated at codon 108/158 of the soluble and membrane bound COMT protein, respectively, whereby a G to A transition results in a valine to methionine substitution, rendering the protein more thermolabile. Methionine 174-184 catechol-O-methyltransferase Homo sapiens 95-99 12168735-2 2002 A COMT valine to methionine polymorphism (G-to-A) in exon 4 of the COMT gene is polymorphic in the human population, with 25% of Caucasians being homozygous for the low-activity allele (COMT-L) of the enzyme. Methionine 17-27 catechol-O-methyltransferase Homo sapiens 2-6 12168735-2 2002 A COMT valine to methionine polymorphism (G-to-A) in exon 4 of the COMT gene is polymorphic in the human population, with 25% of Caucasians being homozygous for the low-activity allele (COMT-L) of the enzyme. Methionine 17-27 catechol-O-methyltransferase Homo sapiens 67-71 12168735-2 2002 A COMT valine to methionine polymorphism (G-to-A) in exon 4 of the COMT gene is polymorphic in the human population, with 25% of Caucasians being homozygous for the low-activity allele (COMT-L) of the enzyme. Methionine 17-27 catechol-O-methyltransferase Homo sapiens 67-71 12168735-6 2002 CONCLUSIONS: Our results suggest that the valine to methionine polymorphism in exon 4 of the COMT gene is not associated with the risk of endometriosis compared to a surgical control population. Methionine 52-62 catechol-O-methyltransferase Homo sapiens 93-97 9535125-2 1998 A functional COMT gene polymorphism influencing the enzyme activities, the high activity (val-108) and the low activity allele (met-108), was recently confirmed. Methionine 128-131 catechol-O-methyltransferase Homo sapiens 13-17 9264133-5 1997 A relatively low activity allele is associated with a methionine residue at amino acid 158 of membrane bound COMT whereas a high activity variant has a valine at this site. Methionine 54-64 catechol-O-methyltransferase Homo sapiens 109-113 9109174-2 1997 A common low-activity variant of the enzyme contains a methionine residue at amino acid 158 of membrane-bound COMT whereas the common high activity variant has a valine at this site. Methionine 55-65 catechol-O-methyltransferase Homo sapiens 110-114 8020475-5 1994 Electrospray MS analysis showed that the smaller rhCOMT protein had a molecular mass of 24352 +/- 2 Da, corresponding to the calculated value for native hCOMT (without the initiating methionine), whereas that mass of the larger protein was of 25775 +/- 4 Da. Methionine 183-193 catechol-O-methyltransferase Homo sapiens 50-55 34305543-8 2021 Yet, when accounting for individual differences in the genetic proxy of the COMT-Val158Met polymorphism (rs4680), we observed that only the participants homozygote for the methionine allele (n = 12; with putatively higher prefrontal dopamine) experienced a decline in model-based control when facing volatile reward probabilities. Methionine 172-182 catechol-O-methyltransferase Homo sapiens 76-80