PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31131233-6 2019 RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels. Methionine 68-78 cystathionine beta-synthase Mus musculus 9-12 33949005-6 2021 In serum, we observe similar elevations in tHcy in both Tg-G307S Cbs-/- and Tg-I278T Cbs-/- compared to control animals, but methionine is much more severely elevated in Tg-G307S Cbs-/- mice. Methionine 125-135 cystathionine beta-synthase Mus musculus 179-182 33949005-7 2021 Large scale metabolomic analysis of liver tissue confirms that both methionine and methionine-sulfoxide are significantly more elevated in Tg-G307S Cbs-/- animals, along with significant differences in several other metabolites including hexoses, amino acids, other amines, lipids, and carboxylic acids. Methionine 68-78 cystathionine beta-synthase Mus musculus 148-151 33949005-8 2021 Our data are consistent with a model that the neonatal lethality observed in CBS-null mice is driven by excess methionine resulting in increased stress on a variety of related pathways including the urea cycle, TCA cycle, gluconeogenesis, and phosphatidylcholine biosynthesis. Methionine 111-121 cystathionine beta-synthase Mus musculus 77-80 31131233-6 2019 RESULTS: CBS deficiency (CBS+/-) coupled with HMD led disruption of methionine/homocysteine (Hcy) metabolism leading to hyperhomocysteinemia (HHcy) in CBS+/- mice as reflected by increased Hcy, and s-adenosylhomocysteine hydrolase (SAHH) levels. Methionine 68-78 cystathionine beta-synthase Mus musculus 25-28 30683311-2 2019 Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs. Methionine 63-73 cystathionine beta-synthase Mus musculus 0-27 30683311-2 2019 Cystathionine-beta-synthase (CBS), an H2S-generating enzyme in methionine metabolism, regulates the function of these EPCs. Methionine 63-73 cystathionine beta-synthase Mus musculus 29-32 26231230-5 2016 Tg-I278T Cbs (-/-) mice on betaine, from the time of weaning until for 240 days of age, had a 40 % decrease in mean tHcy level and a 137 % increase in serum methionine levels. Methionine 157-167 cystathionine beta-synthase Mus musculus 9-12 29635516-8 2018 These changes were associated with alterations in SAM-dependent methylation pathways and expression of the enzymes methionine adenosyltransferase 2A and cystathionine beta synthase. Methionine 115-125 cystathionine beta-synthase Mus musculus 153-180 26599618-1 2016 Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine. Methionine 57-67 cystathionine beta-synthase Mus musculus 0-27 26599618-1 2016 Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine. Methionine 175-185 cystathionine beta-synthase Mus musculus 0-27 26599618-2 2016 Mutations in the CBS gene cause clinical CBS deficiency, a disease characterized by elevated plasma total homocysteine (tHcy) and methionine and decreased plasma cysteine. Methionine 130-140 cystathionine beta-synthase Mus musculus 17-20 26599618-5 2016 Tg-I278T Cbs(-/-) mice have undetectable levels of CBS activity, extremely elevated plasma tHcy, modestly elevated plasma methionine, and low plasma cysteine. Methionine 122-132 cystathionine beta-synthase Mus musculus 9-12 17360897-10 2007 Remarkably, hyperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-methionine, low-folate diet is associated with increased brain S-adenosylhomocysteine levels, PPMT downregulation, reduced PP2A methylation levels, and tau and APP phosphorylation. Methionine 113-123 cystathionine beta-synthase Mus musculus 58-85 20036517-0 2010 Methionine-deficient diet induces post-transcriptional downregulation of cystathionine beta-synthase. Methionine 0-10 cystathionine beta-synthase Mus musculus 73-100 20036517-5 2010 Because CBS is a key regulator of tHcy, we examined CBS protein levels and found that within 3 d on the methionine-deficient diet, animals had a 50% reduction in the levels of liver CBS protein and enzyme activity. Methionine 104-114 cystathionine beta-synthase Mus musculus 8-11 20036517-5 2010 Because CBS is a key regulator of tHcy, we examined CBS protein levels and found that within 3 d on the methionine-deficient diet, animals had a 50% reduction in the levels of liver CBS protein and enzyme activity. Methionine 104-114 cystathionine beta-synthase Mus musculus 52-55 20036517-8 2010 CONCLUSION: Our results imply that methionine deprivation induces a metabolic state in which methionine is effectively conserved in tissue by shutdown of the transsulfuration pathway by an S-adenosylmethionine-independent mechanism that signals a rapid downregulation of CBS protein. Methionine 35-45 cystathionine beta-synthase Mus musculus 271-274 20036517-8 2010 CONCLUSION: Our results imply that methionine deprivation induces a metabolic state in which methionine is effectively conserved in tissue by shutdown of the transsulfuration pathway by an S-adenosylmethionine-independent mechanism that signals a rapid downregulation of CBS protein. Methionine 93-103 cystathionine beta-synthase Mus musculus 271-274 25772816-9 2015 Addition of homocysteine or methionine resulted in higher intracellular concentrations of homocysteine, which is a cosubstrate for cystathionine beta-synthase (CBS). Methionine 28-38 cystathionine beta-synthase Mus musculus 131-158 24189943-0 2014 Cystathionine beta-synthase-deficient mice thrive on a low-methionine diet. Methionine 59-69 cystathionine beta-synthase Mus musculus 0-27 23315129-1 2013 Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. Methionine 166-176 cystathionine beta-synthase Mus musculus 0-27 23315129-1 2013 Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration. Methionine 166-176 cystathionine beta-synthase Mus musculus 29-32 17663144-1 2007 CBS is a vitamin B6-dependent transsulfuration enzyme needed to synthesize cysteine from methionine, catalyzing the condensation of serine with homocysteine to form cystathionine. Methionine 89-99 cystathionine beta-synthase Mus musculus 0-3 15105297-6 2004 Tg-CBS mice maintained on a high-methionine, low-folate diet also had significantly lower serum homocysteine compared with control animals (179 micromol/L versus 242 micromol/L; P<0.02). Methionine 33-43 cystathionine beta-synthase Mus musculus 3-6 17937607-3 2007 Deficiencies in cystathionine beta-synthase lead to elevated plasma methionine, while deficiencies of the remaining three enzymes lead to hypomethioninemia. Methionine 68-78 cystathionine beta-synthase Mus musculus 16-43 16160063-1 2005 Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine. Methionine 98-108 cystathionine beta-synthase Mus musculus 0-27 16160063-1 2005 Cystathionine beta-synthase (CBS; EC 4.2.1.22) is a key enzyme in the generation of cysteine from methionine. Methionine 98-108 cystathionine beta-synthase Mus musculus 29-32 34853730-3 2021 Here, we found that lncRNA TGFB3-AS1 was highly expressed in macrophages treated with Hcy and the peripheral blood monocytes from cystathionine beta-synthase heterozygous knockout (CBS +/-) mice with a high-methionine diet using lncRNA microarray. Methionine 207-217 cystathionine beta-synthase Mus musculus 130-157