PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27374276-7 2017 The serum concentrations of carboxylated OC and undercarboxylated OC were increased (p = 0.01) and reduced (p = 0.02), respectively, after daily intake of 180 mug of synthetic MK-7 for 43 days, indicating increased vitamin K activity. vitamin MK 7 176-180 bone gamma-carboxyglutamate protein Homo sapiens 66-68 33030563-10 2021 RESULTS: Undercarboxylated osteocalcin decreased in the MK-7-group (- 65.2 +- 23.5%) (mean +- SD) compared with the placebo group (- 0.03 +- 38.5%), p < 0.01 after 1 year. vitamin MK 7 56-60 bone gamma-carboxyglutamate protein Homo sapiens 27-38 33030563-15 2021 CONCLUSION: Treatment with MK-7 375 mug daily as an add-on to calcium and vitamin D increased carboxylation of osteocalcin. vitamin MK 7 27-31 bone gamma-carboxyglutamate protein Homo sapiens 111-122 34945687-7 2021 The effective dose to decrease uncarboxylated osteocalcin was six times lower for MK-7 than for MK-4. vitamin MK 7 82-86 bone gamma-carboxyglutamate protein Homo sapiens 46-57 23109511-5 2015 Considering genes involved in bone formation and mineralization, our data show that vitamin MK-7 enhances vitamin D3 gene induction of osteocalcin (OC). vitamin MK 7 84-96 bone gamma-carboxyglutamate protein Homo sapiens 135-146 26073022-11 2015 In the cross sectional study, a significant decrease in MK-7 treated group for the levels of undercarboxylated osteocalcin (ucOC), erythrocyte sedimentation rate (ESR), disease activity score assessing 28 joints with ESR (DAS28-ESR), C-reactive protein (CRP) and matrix metalloproteinase (MMP-3) was found. vitamin MK 7 56-60 bone gamma-carboxyglutamate protein Homo sapiens 111-122 28620475-9 2016 MK-7 showed a significant inverse correlation with uncarboxylated osteocalcin (ucOC, P = 0 014), protein induced by vitamin K absence of antagonist-2 (PIVKA-2, P = 0 013), intact parathyroid hormone (P = 0 007) and bone-specific alkaline phosphatase (P = 0 018). vitamin MK 7 0-4 bone gamma-carboxyglutamate protein Homo sapiens 66-77 19450370-0 2009 The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children. vitamin MK 7 14-27 bone gamma-carboxyglutamate protein Homo sapiens 60-71 23062766-7 2012 The osteocalcin ratio also decreased significantly after 12-week supplementation with 180 mug (60%) and 360 mug (74%) MK-7 (P time*treatment < 0.001), while levels remained unchanged after placebo treatment. vitamin MK 7 118-122 bone gamma-carboxyglutamate protein Homo sapiens 4-15 19450370-4 2009 The objective was to study the effect of 45 microg menaquinone-7 (MK-7; one of the vitamin K2 species) on the circulating levels of undercarboxylated osteocalcin (ucOC) and carboxylated osteocalcin (cOC) in healthy prepubertal children. vitamin MK 7 51-64 bone gamma-carboxyglutamate protein Homo sapiens 150-161 19450370-4 2009 The objective was to study the effect of 45 microg menaquinone-7 (MK-7; one of the vitamin K2 species) on the circulating levels of undercarboxylated osteocalcin (ucOC) and carboxylated osteocalcin (cOC) in healthy prepubertal children. vitamin MK 7 51-64 bone gamma-carboxyglutamate protein Homo sapiens 186-197 19450370-4 2009 The objective was to study the effect of 45 microg menaquinone-7 (MK-7; one of the vitamin K2 species) on the circulating levels of undercarboxylated osteocalcin (ucOC) and carboxylated osteocalcin (cOC) in healthy prepubertal children. vitamin MK 7 66-70 bone gamma-carboxyglutamate protein Homo sapiens 150-161 19450370-4 2009 The objective was to study the effect of 45 microg menaquinone-7 (MK-7; one of the vitamin K2 species) on the circulating levels of undercarboxylated osteocalcin (ucOC) and carboxylated osteocalcin (cOC) in healthy prepubertal children. vitamin MK 7 66-70 bone gamma-carboxyglutamate protein Homo sapiens 186-197 19450370-6 2009 The present study is a double-blind randomised placebo-controlled trial examining the effect of 8 weeks MK-7 supplementation on the carboxylation of osteocalcin in healthy children (n 55). vitamin MK 7 104-108 bone gamma-carboxyglutamate protein Homo sapiens 149-160 19450370-12 2009 These findings demonstrate that in healthy, prepubertal children, modest supplementation with MK-7 increases circulating concentrations of MK-7 and increases osteocalcin carboxylation. vitamin MK 7 94-98 bone gamma-carboxyglutamate protein Homo sapiens 158-169 17158229-8 2007 MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way. vitamin MK 7 0-4 bone gamma-carboxyglutamate protein Homo sapiens 44-55 16469998-2 2006 Phylloquinone (K1) and menaquinone 4 (MK-4) and 7 (MK-7) are generally observed in human plasma; however, data are limited on their circulating concentrations and their associations with bone metabolism or with gamma-carboxylation of the osteocalcin molecule. vitamin MK 7 51-55 bone gamma-carboxyglutamate protein Homo sapiens 238-249