PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18573489-8	2008	By using cell lines defective in both APAF-1 and MGMT, it was revealed that the APAF-1 function is required for execution of apoptosis induced by either TMZ or ACNU.	Nimustine	160-164	O-6-methylguanine-DNA methyltransferase	Mus musculus	49-53	
11023546-6	2000	Increased sensitivity of MGMT(-/-) mice to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosou rea (ACNU), a bifunctional nitrosourea, was also noted.	Nimustine	43-116	O-6-methylguanine-DNA methyltransferase	Mus musculus	25-29	
12189523-3	2002	Whereas 20/20 control animals transplanted with nontransduced cells died of progressive myelosuppression during therapy, nearly all animals transplanted with MGMT(P140K)-transduced cells survived treatment with BG/ACNU (12/15), BG/TMZ (10/10), or BG/BCNU (5/5).	Nimustine	214-218	O-6-methylguanine-DNA methyltransferase	Mus musculus	158-162	
16309194-7	2005	The drug effect of ACNU, which depends on the MGMT status, was verified using xenograft tumors grown in nude mice.	Nimustine	19-23	O-6-methylguanine-DNA methyltransferase	Mus musculus	46-50	
11553261-6	2001	In comparison to mock-transduced controls, after transduction with N2/Zip-PGK-MGMT the IC50 for CFU increased on average 4.7-fold for ACNU, 2.5-fold for BCNU, 6.3-fold for CCNU and 1.5-fold for temozolomide.	Nimustine	134-138	O-6-methylguanine-DNA methyltransferase	Mus musculus	78-82	
11023546-6	2000	Increased sensitivity of MGMT(-/-) mice to 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosou rea (ACNU), a bifunctional nitrosourea, was also noted.	Nimustine	118-122	O-6-methylguanine-DNA methyltransferase	Mus musculus	25-29	
9815770-12	1997	Murine bone marrow cells transduced with Ha-MDR-IRES-MGMT and selected with vincristine also showed simultaneous resistance to vincristine and ACNU.	Nimustine	143-147	O-6-methylguanine-DNA methyltransferase	Mus musculus	53-57	
8562657-0	1995	[Modulation of the antitumor activity of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosoure a by O(6)-methyl-2"-deoxyguanosine--a new inhibitor of O(6)-alkylguanine-DNA-alkyltransferase].	Nimustine	41-114	O-6-methylguanine-DNA methyltransferase	Mus musculus	168-206	
8562657-11	1995	The activation of some repairing enzymes, such as O6-AGT, DNA-polymerases alpha and beta as well as increased levels of GSH may play a role in the development of drug resistance to ACNU.	Nimustine	181-185	O-6-methylguanine-DNA methyltransferase	Mus musculus	50-56	
8562657-10	1995	The activities of DNA-polymerases alpha and beta and, especially, of O6-AGT were elevated in ACNU-resistant leukemia cells as compared with ACNU-sensitive cells.	Nimustine	93-97	O-6-methylguanine-DNA methyltransferase	Mus musculus	69-75	
8562657-10	1995	The activities of DNA-polymerases alpha and beta and, especially, of O6-AGT were elevated in ACNU-resistant leukemia cells as compared with ACNU-sensitive cells.	Nimustine	140-144	O-6-methylguanine-DNA methyltransferase	Mus musculus	69-75