PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21962147-1 2011 A series of diazabicyclo[3.3.0]octane substituted pyridines and pyrazines was synthesized and characterized at the alpha4beta2 neuronal nicotinic acetylcholine receptor (nAChR). Pyrazines 64-73 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 170-175 11557356-4 2001 The bioisosteric replacement of the acetyl moiety as structural part of the lead compound 3 with the pyridazine, pyrimidine and pyrazine nucleus resulted in ligands with high to moderate affinity for the central alpha4beta2 and remarkably low affinity for the alpha7* nAChR subtypes. Pyrazines 128-136 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 268-273