PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17875720-8 2007 In vitro pretreatment with NS-123 resulted in accumulation of unrepaired IR-induced DNA strand breaks and prolonged phosphorylation of the surrogate markers of DNA damage H2AX, ataxia telangiectasia mutated protein, DNA-dependent protein kinase, and CHK2 after IR, suggesting that NS-123 inhibits a critical step in the DNA repair pathway. 4'-bromo-3'-nitropropiophenone 27-33 checkpoint kinase 2 Homo sapiens 250-254