PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23164657-1	2012	A convenient and unprecedented synthesis of functionally enriched octahydroindole-based scaffolds has been developed via inter- and intra-molecular amidolysis of C-3 functionalized beta-lactams.	beta-Lactams	181-193	complement C3	Homo sapiens	162-165	
31965920-0	2019	A Comprehensive Review on C-3 Functionalization of beta-Lactams.	beta-Lactams	51-63	complement C3	Homo sapiens	26-29	
31965920-3	2019	The C-3 functionalization of beta-lactams has continued to attract considerable interest of the scientific community due to their utility as versatile intermediates in organic synthesis and their therapeutic applications.	beta-Lactams	29-41	complement C3	Homo sapiens	4-7	
31965920-4	2019	This has led to the significant increase in efforts towards developing efficient and economic strategies for C-3 functionalized beta-lactams.	beta-Lactams	128-140	complement C3	Homo sapiens	109-112	
31965920-7	2019	The C-3 carbocation equivalent method has emerged as an important and convenient strategy for C-3 functionalization of beta-lactam heterocycles which provides a wide range of beta-lactams viz.	beta-Lactams	119-130	complement C3	Homo sapiens	4-7	
31965920-7	2019	The C-3 carbocation equivalent method has emerged as an important and convenient strategy for C-3 functionalization of beta-lactam heterocycles which provides a wide range of beta-lactams viz.	beta-Lactams	119-130	complement C3	Homo sapiens	94-97	
31965920-7	2019	The C-3 carbocation equivalent method has emerged as an important and convenient strategy for C-3 functionalization of beta-lactam heterocycles which provides a wide range of beta-lactams viz.	beta-Lactams	175-187	complement C3	Homo sapiens	4-7	
31965920-7	2019	The C-3 carbocation equivalent method has emerged as an important and convenient strategy for C-3 functionalization of beta-lactam heterocycles which provides a wide range of beta-lactams viz.	beta-Lactams	175-187	complement C3	Homo sapiens	94-97	
1800523-7	1991	The hydrophobic increments for the sixteen most common cephalosporin C-3-substituents were empirically evaluated from literature data, and a simple equation was derived for an overall beta-lactam antibiotic hydrophobicity calculation.	beta-Lactams	184-195	complement C3	Homo sapiens	69-72	
14642583-4	2003	We demonstrate that C-4 unsaturation on the beta-lactam ring determines the degree of biological activity, with a selectivity over LE by 3-[1-(tert-butyldimethylsilyloxy)-ethyl] derivatives (lowest IC(50) was 4 microM), and over gelatinase MMP-2 by C-3-unsubstituted 4-[1-ethoxycarbonyl]-ethylidene-beta-lactams (lowest IC(50) was 60 microM).	beta-Lactams	44-55	complement C3	Homo sapiens	249-252	
9667976-2	1998	Substitution with small groups at the C-3 position of the beta-lactam ring gave an increase in enzymatic activity and in stability; however, a lack of selectivity against other serine proteases was noted.	beta-Lactams	58-69	complement C3	Homo sapiens	38-41