PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26937601-3	2016	Optimization of the pyrimidine substituent that binds in the S2"-S2"" pocket of BACE1 remediated time-dependent CYP3A4 inhibition of earlier analogues in this series and imparted high BACE1 affinity.	pyrimidine	20-30	beta-secretase 1	Rattus norvegicus	80-85	
26937601-3	2016	Optimization of the pyrimidine substituent that binds in the S2"-S2"" pocket of BACE1 remediated time-dependent CYP3A4 inhibition of earlier analogues in this series and imparted high BACE1 affinity.	pyrimidine	20-30	beta-secretase 1	Rattus norvegicus	184-189	
24595682-0	2014	Elucidating the mechanism of cytochrome P450-mediated pyrimidine ring conversion to pyrazole metabolites with the BACE1 inhibitor GNE-892 in rats.	pyrimidine	54-64	beta-secretase 1	Rattus norvegicus	114-119