PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30985967-1	2019	OBJECTIVE: Thymidine kinase 1 (TK1) is a key enzyme in the pyrimidine salvage pathway.	pyrimidine	59-69	thymidine kinase 1	Homo sapiens	11-29	
31383553-9	2019	INTERPRETATIONS: These data indicate that the cytosolic pyrimidine salvage pathway enzymes TK1 and dCK are critical for therapeutic efficacy of deoxynucleoside therapy for Tk2 deficiency.	pyrimidine	56-66	thymidine kinase 1	Homo sapiens	91-94	
30985967-1	2019	OBJECTIVE: Thymidine kinase 1 (TK1) is a key enzyme in the pyrimidine salvage pathway.	pyrimidine	59-69	thymidine kinase 1	Homo sapiens	31-34	
21127790-5	2011	Introduction of a 2-bromovinyl group on C-5 of the pyrimidine base of the most promising 3"-derivative further improved the inhibitory activity, and caused a significant increase in the selectivity for TK2 versus TK1.	pyrimidine	51-61	thymidine kinase 1	Homo sapiens	213-216	
16473525-1	2006	Human cytosolic thymidine kinase (hTK1) is the key enzyme of the pyrimidine salvage pathway and phosphorylates thymidine to thymidine monophosphate, a precursor building block of the DNA.	pyrimidine	65-75	thymidine kinase 1	Homo sapiens	34-38	
20372850-0	2010	Immunohistochemical characterization of pyrimidine synthetic enzymes, thymidine kinase-1 and thymidylate synthase, in various types of cancer.	pyrimidine	40-50	thymidine kinase 1	Homo sapiens	70-88	
20372850-1	2010	Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively.	pyrimidine	96-106	thymidine kinase 1	Homo sapiens	0-18	
20372850-1	2010	Thymidine kinase-1 (TK-1) and thymidylate synthase (TS) are key enzymes for salvage and de novo pyrimidine synthesis, respectively.	pyrimidine	96-106	thymidine kinase 1	Homo sapiens	20-24	
17707801-1	2007	INTRODUCTION: The activity of the pyrimidine salvage pathway enzyme thymidine kinase 1 (TK1) is tightly cell cycle regulated and has been investigated as a prognostic indicator of cancer in a variety of tissues.	pyrimidine	34-44	thymidine kinase 1	Homo sapiens	68-86	
17707801-1	2007	INTRODUCTION: The activity of the pyrimidine salvage pathway enzyme thymidine kinase 1 (TK1) is tightly cell cycle regulated and has been investigated as a prognostic indicator of cancer in a variety of tissues.	pyrimidine	34-44	thymidine kinase 1	Homo sapiens	88-91	
12123744-4	2002	Study of cellular mechanisms responsible for cross-resistance to pyrimidine analogs in AZT-resistant H9 cells revealed decreased mRNA levels of thymidine kinase 1 (TK1) and lack of deoxycytidine kinase (dCK) mRNA expression.	pyrimidine	65-75	thymidine kinase 1	Homo sapiens	144-162	
15583816-1	2005	Thymidine kinase 1 (TK1) is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis and thus, a cell cycle-dependent marker.	pyrimidine	30-40	thymidine kinase 1	Homo sapiens	0-18	
15583816-1	2005	Thymidine kinase 1 (TK1) is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis and thus, a cell cycle-dependent marker.	pyrimidine	30-40	thymidine kinase 1	Homo sapiens	20-23	
12123744-4	2002	Study of cellular mechanisms responsible for cross-resistance to pyrimidine analogs in AZT-resistant H9 cells revealed decreased mRNA levels of thymidine kinase 1 (TK1) and lack of deoxycytidine kinase (dCK) mRNA expression.	pyrimidine	65-75	thymidine kinase 1	Homo sapiens	164-167	
34579716-8	2021	The purified feline TK1 phosphorylated not only pyrimidine deoxyribonucleosides but also pyrimidine ribonucleosides and to some extent purine deoxynucleosides.	pyrimidine	48-58	thymidine kinase 1	Homo sapiens	20-23	
7632720-3	1995	Here, we report that the two forms of TK1 differ manyfold in affinity to the substrate ATP, to the inhibitor dTTP and to various analogs of thymidine substituted in the pyrimidine or sugar.	pyrimidine	169-179	thymidine kinase 1	Homo sapiens	38-41	
32317865-1	2020	Background: Thymidine kinase 1 (TK1) is a pyrimidine salvage pathway enzyme that is up-regulated in malignant tissues and elevated in the serum of cancer patients.	pyrimidine	42-52	thymidine kinase 1	Homo sapiens	12-30	
32638267-11	2020	Overall, our results suggested the mRNA levels of pyrimidine metabolic rate-limiting enzymes CAD, DTYMK, RRM1, RRM2, TK1, TYMS, UCK2, NR5C2, and TK2 were predictive of lung cancer as well as other cancers.	pyrimidine	50-60	thymidine kinase 1	Homo sapiens	117-120	
32317865-1	2020	Background: Thymidine kinase 1 (TK1) is a pyrimidine salvage pathway enzyme that is up-regulated in malignant tissues and elevated in the serum of cancer patients.	pyrimidine	42-52	thymidine kinase 1	Homo sapiens	32-35