PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31113844-6 2019 RESULTS: In examining modulations within the pyrimidine pathway, we identified that the addition of DTX to cells treated with ADI-PEG20 resulted in translocation of stabilized c-Myc to the nucleus. pyrimidine 45-55 MYC proto-oncogene, bHLH transcription factor Homo sapiens 176-181 11035006-1 2001 A major control element of the human c-myc oncogene is the nuclease-hypersensitive purine/pyrimidine-rich sequence. pyrimidine 90-100 MYC proto-oncogene, bHLH transcription factor Homo sapiens 37-42 8940139-2 1996 The THZif-1 protein bound specifically to the single-stranded (ss) pyrimidine-rich DNA of the NHE (ss c-myc NHE-C) with an apparent dissociation constant (Kd (app)) of 0.077 microM. pyrimidine 67-77 MYC proto-oncogene, bHLH transcription factor Homo sapiens 102-107 8601634-2 1996 The ability of c-Myc to bind the sequence CAC(G/A)TG and transactivate appears to be linked to its transforming activity; however, c-Myc also represses transcription in vitro through a pyrimidine-rich cis element termed the initiator (Inr). pyrimidine 185-195 MYC proto-oncogene, bHLH transcription factor Homo sapiens 15-20 8601634-2 1996 The ability of c-Myc to bind the sequence CAC(G/A)TG and transactivate appears to be linked to its transforming activity; however, c-Myc also represses transcription in vitro through a pyrimidine-rich cis element termed the initiator (Inr). pyrimidine 185-195 MYC proto-oncogene, bHLH transcription factor Homo sapiens 131-136 8701093-16 1996 A specific DNA binding element in the promoter region of the c-myc proto-oncogene has been identified as AT-rich domain of homopurine/pyrimidine stretches flanked by GC-rich sequences. pyrimidine 134-144 MYC proto-oncogene, bHLH transcription factor Homo sapiens 61-66 7794930-3 1995 The human c-myc protooncogene contains a 23 base pair purine-pyrimidine-rich motif (-62 to -40) within its predominant promoter, P2, that is a potential target for purine-purine-pyrimidine triplex formation. pyrimidine 61-71 MYC proto-oncogene, bHLH transcription factor Homo sapiens 10-15 7794930-3 1995 The human c-myc protooncogene contains a 23 base pair purine-pyrimidine-rich motif (-62 to -40) within its predominant promoter, P2, that is a potential target for purine-purine-pyrimidine triplex formation. pyrimidine 178-188 MYC proto-oncogene, bHLH transcription factor Homo sapiens 10-15 7876260-1 1995 We have previously reported that heterogeneous nuclear ribonucleoprotein K (hnRNP K) binds to the pyrimidine-rich strand of the CT element found in the human c-myc gene and activates CT reporter-driven gene expression in vivo. pyrimidine 98-108 MYC proto-oncogene, bHLH transcription factor Homo sapiens 158-163 34009981-0 2021 Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins. pyrimidine 29-39 MYC proto-oncogene, bHLH transcription factor Homo sapiens 90-93 34009981-2 2021 Here, we describe the design and synthesis of a series of pyrimidine-based derivatives able to inhibit Aurora A kinase activity and reduce levels of cMYC and MYCN. pyrimidine 58-68 MYC proto-oncogene, bHLH transcription factor Homo sapiens 149-153 28847964-8 2017 Moreover, inhibition of MYC target pyrimidine synthesis genes such as CAD, UMPS, and CTPS blocked cell growth, and thus are potential targets for colorectal cancer therapy. pyrimidine 35-45 MYC proto-oncogene, bHLH transcription factor Homo sapiens 24-27 18628958-3 2008 METHODOLOGY/PRINCIPAL FINDINGS: Here, we report that the majority of genes in human purine and pyrimidine biosynthesis pathway were induced and directly bound by c-Myc in the P493-6 human Burkitt"s lymphoma model cell line. pyrimidine 95-105 MYC proto-oncogene, bHLH transcription factor Homo sapiens 162-167 16317762-6 2006 It preferentially cleaves RNA in between the pyrimidine and purine dinucleotides UA, UG, and CA, at the coding region determinant (CRD) of c-myc RNA. pyrimidine 45-55 MYC proto-oncogene, bHLH transcription factor Homo sapiens 139-144 8831693-5 1996 Moreover, MAZi protein bound specifically to the pyrimidine-rich strand of the CT-element of the c-myc gene in vitro and strongly induced the expression of chloramphenicol acetyltransferase (CAT) from a c-myc promoter/ CAT reporter construct in human pancreatic cells. pyrimidine 49-59 MYC proto-oncogene, bHLH transcription factor Homo sapiens 97-102