PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	pyrimidine	31-41	polo like kinase 1	Homo sapiens	78-82	
34500603-0	2021	Synthetic Strategies of Pyrimidine-Based Scaffolds as Aurora Kinase and Polo-like Kinase Inhibitors.	pyrimidine	24-34	polo like kinase 1	Homo sapiens	72-88	
34500603-8	2021	Within the numerous pyrimidine-based small molecules developed as anticancer agents, this review focuses on the pyrimidine fused heterocyclic compounds modulating the AURK and PLK proteins in different phases of clinical trials as anticancer agents.	pyrimidine	112-122	polo like kinase 1	Homo sapiens	176-179	
34500603-9	2021	This article aims to provide a comprehensive overview of synthetic strategies for the preparation of pyrimidine derivatives and their associated biological activity on AURK/PLK.	pyrimidine	101-111	polo like kinase 1	Homo sapiens	168-176	
26191363-4	2015	Meanwhile, substitution of the pyrimidine NH with an oxygen atom reversed the PLK1/BRD4 selectivity to convert BI-2536 into a BRD4-selective inhibitor, likely owing to the loss of a critical hydrogen bond in PLK1.	pyrimidine	31-41	polo like kinase 1	Homo sapiens	208-212