PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2301378-1 1990 The effect of azidothymidine (Zidovudine, AZT) on pyrimidine (thymidine, deoxyuridine, and thymidine triphosphate) incorporation into DNA in folate- and/or vitamin B12-deficient and normal human bone marrow cells was studied to investigate whether such vitamin deficiency affects susceptibility to AZT-induced hematologic toxicity. pyrimidine 50-60 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 164-167 2301378-3 1990 At 0.2 microM AZT (3 hr, 37 degrees C), the approximate pharmacologic serum trough level, pyrimidine incorporation into DNA was suppressed by 12 to 19% in folate- and/or vitamin B12-deficient cells and by 16 to 23% in normal cells. pyrimidine 90-100 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 178-181 465362-0 1979 Altered erythrocyte pyrimidine activity in vitamin B12 or folate deficiency. pyrimidine 20-30 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 51-54 465362-5 1979 In vitamin B12 or folate deficiency an impressive array of evidence now exists to implicate altered folate metabolism for the observed alterations in purine and pyrimidine metabolism (Das & Herbert, 1976). pyrimidine 161-171 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 11-14