PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32830091-4 2020 PATIENTS AND METHODS: We measured the relative expression levels of three pyrimidine-metabolizing genes-thymidylate synthase (TYMS), thymidine phosphorylase (TYMP), and dihydropyrimidine dehydrogenase (DPYD)-in tumor tissue and adjacent normal-appearing mucosa in 50 colon cancer (CC) patients using real-time reverse-transcription polymerase chain reaction. pyrimidine 74-84 thymidine phosphorylase Homo sapiens 133-156 30563166-11 2018 Thymidine phosphorylase (TP), a main role of the pyrimidine salvage pathway, was also highly inhibited by the combination treatment. pyrimidine 49-59 thymidine phosphorylase Homo sapiens 0-23 29803079-1 2018 Thymidine phosphorylase is an enzyme involved in pyrimidine salvage pathway that is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and gliostatin. pyrimidine 49-59 thymidine phosphorylase Homo sapiens 97-144 29803079-1 2018 Thymidine phosphorylase is an enzyme involved in pyrimidine salvage pathway that is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and gliostatin. pyrimidine 49-59 thymidine phosphorylase Homo sapiens 146-153 29803079-1 2018 Thymidine phosphorylase is an enzyme involved in pyrimidine salvage pathway that is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and gliostatin. pyrimidine 49-59 thymidine phosphorylase Homo sapiens 159-169 22274133-7 2012 In MNGIE, loss of TP activity causes toxic accumulations of the nucleosides thymidine and deoxyuridine that are incorporated by the mitochondrial pyrimidine salvage pathway and cause deoxynucleoside triphosphate pool imbalances, which, in turn cause mtDNA instability. pyrimidine 146-156 thymidine phosphorylase Homo sapiens 18-20 27783978-1 2016 Thymidine phosphorylase (TP, EC 2.4.2.4), an enzyme involved in pyrimidine salvage pathway, is identical to platelet-derived endothelial cell growth factor (PD-ECGF) and gliostatin. pyrimidine 64-74 thymidine phosphorylase Homo sapiens 108-155 24447935-3 2014 Thymidine phosphorylase (TP) is an enzyme of the pyrimidine salvage pathway which is upregulated in cancers. pyrimidine 49-59 thymidine phosphorylase Homo sapiens 0-23 24447935-3 2014 Thymidine phosphorylase (TP) is an enzyme of the pyrimidine salvage pathway which is upregulated in cancers. pyrimidine 49-59 thymidine phosphorylase Homo sapiens 25-27 11099324-1 2000 PURPOSE: Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine salvage enzyme responsible for degradation of thymine, which is produced from thymidine by thymidine phosphorylase (TP). pyrimidine 16-26 thymidine phosphorylase Homo sapiens 154-177 21791367-1 2011 INTRODUCTION/BACKGROUND: Pyrimidine antimetabolites" target molecules thymidylate synthase (TS) and flopropyrimidine-metabolising enzymes such as dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyltransferase (OPRT) are known as biomarkers of 5-fluorouracil (5-FU) treatment. pyrimidine 25-35 thymidine phosphorylase Homo sapiens 185-208 21791367-1 2011 INTRODUCTION/BACKGROUND: Pyrimidine antimetabolites" target molecules thymidylate synthase (TS) and flopropyrimidine-metabolising enzymes such as dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyltransferase (OPRT) are known as biomarkers of 5-fluorouracil (5-FU) treatment. pyrimidine 25-35 thymidine phosphorylase Homo sapiens 210-212 21444628-3 2011 TS and thymidine phosphorylase (TP) are key enzymes of the pyrimidine salvage pathway. pyrimidine 59-69 thymidine phosphorylase Homo sapiens 32-34 21444628-3 2011 TS and thymidine phosphorylase (TP) are key enzymes of the pyrimidine salvage pathway. pyrimidine 59-69 thymidine phosphorylase Homo sapiens 7-30 16375757-1 2005 Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2"-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. pyrimidine 75-85 thymidine phosphorylase Homo sapiens 0-23 16375757-1 2005 Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2"-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. pyrimidine 75-85 thymidine phosphorylase Homo sapiens 25-30 16375757-1 2005 Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2"-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. pyrimidine 156-166 thymidine phosphorylase Homo sapiens 0-23 16375757-1 2005 Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2"-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties. pyrimidine 156-166 thymidine phosphorylase Homo sapiens 25-30 11099324-1 2000 PURPOSE: Dihydropyrimidine dehydrogenase (DPD) is a pyrimidine salvage enzyme responsible for degradation of thymine, which is produced from thymidine by thymidine phosphorylase (TP). pyrimidine 16-26 thymidine phosphorylase Homo sapiens 179-181 10971175-1 2000 OBJECTIVE: Thymidylate synthase (TS) and thymidine phosphorylase (TP) are important enzymes involved in the de novo DNA synthesis and the salvage pathways for pyrimidine, respectively. pyrimidine 159-169 thymidine phosphorylase Homo sapiens 41-64 10971175-1 2000 OBJECTIVE: Thymidylate synthase (TS) and thymidine phosphorylase (TP) are important enzymes involved in the de novo DNA synthesis and the salvage pathways for pyrimidine, respectively. pyrimidine 159-169 thymidine phosphorylase Homo sapiens 66-68 9626068-8 1998 We conclude that PD-ECGF/TP may affect angiogenesis by changing the relative concentrations of pyrimidine-based compounds and their metabolites in interstitial fluid surrounding endothelial cells. pyrimidine 95-105 thymidine phosphorylase Homo sapiens 17-24 10468288-2 1999 Transfecting the human TP cDNA into cancer cells in order to sensitize them to these pyrimidine antimetabolites may be an important approach in human cancer gene therapy research. pyrimidine 85-95 thymidine phosphorylase Homo sapiens 23-25 9537263-8 1998 TP/PD-ECGF mRNA also has a pyrimidine-rich sequence at its 3" end that was similar to a motif that has been reported to mediate increased mRNA stability in other genes. pyrimidine 27-37 thymidine phosphorylase Homo sapiens 3-10 9052401-4 1997 In this study, we examined whether transfection of tumour cells with a human platelet-derived endothelial cell growth factor (PD-ECGF) complementary DNA (cDNA) expressing dThdPase would sensitize the cells to the cytotoxic effects of pyrimidine antimetabolites in vitro. pyrimidine 234-244 thymidine phosphorylase Homo sapiens 77-124 9052401-4 1997 In this study, we examined whether transfection of tumour cells with a human platelet-derived endothelial cell growth factor (PD-ECGF) complementary DNA (cDNA) expressing dThdPase would sensitize the cells to the cytotoxic effects of pyrimidine antimetabolites in vitro. pyrimidine 234-244 thymidine phosphorylase Homo sapiens 126-133 7627962-6 1995 One of the compounds, the novel pyrimidine analogue 5-ethoxy-2"-deoxyuridine (EOdU), was found to be a substrate for the transferase reaction of TP, to have little or no direct cytotoxicity, to selectively increase the cellular levels of 5-fluoro-dUMP, to enhance the inhibitory effect of FUra on thymidylate synthase activity, and to potentiate the cytotoxicity of FUra and IFN in human colon carcinoma cells. pyrimidine 32-42 thymidine phosphorylase Homo sapiens 145-147 19824457-0 2009 [Influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase from normal and tumor endometrial cells]. pyrimidine 27-37 thymidine phosphorylase Homo sapiens 67-90 19824457-1 2009 OBJECTIVES: The aim of this study was to evaluate the influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase (TP) of normal and tumor endometrial cells. pyrimidine 80-90 thymidine phosphorylase Homo sapiens 120-143 19824457-1 2009 OBJECTIVES: The aim of this study was to evaluate the influence of the selected pyrimidine compounds on the activity of thymidine phosphorylase (TP) of normal and tumor endometrial cells. pyrimidine 80-90 thymidine phosphorylase Homo sapiens 145-147 33874986-4 2021 Cytidine deaminase (CDA) and thymidine phosphorylase (TYMP) are key enzymes of the pyrimidine salvage pathway. pyrimidine 83-93 thymidine phosphorylase Homo sapiens 54-58 9492828-1 1998 Thymidine phosphorylase (TdRPase) is an enzyme involved in the pyrimidine metabolism. pyrimidine 63-73 thymidine phosphorylase Homo sapiens 25-32 8137250-8 1994 The pyrimidine analogue 5-propynyloxy-2"-deoxyuridine (PO-dUrd) had 15% of the maximal TP activity in cell extracts and also increased thymine incorporation in intact cells 10-fold. pyrimidine 4-14 thymidine phosphorylase Homo sapiens 87-89