PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32032847-0 2020 Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology. pyrimidine 43-53 matrix metallopeptidase 10 Homo sapiens 97-127 32032847-5 2020 Starting with a lead fused pyrimidine-based MMP-13 inhibitor with weak MMP-10 inhibition, a structure-based design of pyrimidine and fused pyrimidine scaffolds was rationalized to enhance activity against MMP-10 in parallel with MMP-13. pyrimidine 27-37 matrix metallopeptidase 10 Homo sapiens 205-211 32032847-5 2020 Starting with a lead fused pyrimidine-based MMP-13 inhibitor with weak MMP-10 inhibition, a structure-based design of pyrimidine and fused pyrimidine scaffolds was rationalized to enhance activity against MMP-10 in parallel with MMP-13. pyrimidine 118-128 matrix metallopeptidase 10 Homo sapiens 205-211 32032847-5 2020 Starting with a lead fused pyrimidine-based MMP-13 inhibitor with weak MMP-10 inhibition, a structure-based design of pyrimidine and fused pyrimidine scaffolds was rationalized to enhance activity against MMP-10 in parallel with MMP-13. pyrimidine 118-128 matrix metallopeptidase 10 Homo sapiens 205-211