PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3880742-3	1985	For TMP bound to chicken dihydrofolate reductase we observe an altered binding geometry in which the 2,4-diaminopyrimidine occupies a position in closer proximity (by approximately 1 A) to helix alpha B compared to the pyrimidine position for TMP or methotrexate bound to E. coli dihydrofolate reductase.	pyrimidine	112-122	dihydrofolate reductase	Gallus gallus	25-48	
3880742-3	1985	For TMP bound to chicken dihydrofolate reductase we observe an altered binding geometry in which the 2,4-diaminopyrimidine occupies a position in closer proximity (by approximately 1 A) to helix alpha B compared to the pyrimidine position for TMP or methotrexate bound to E. coli dihydrofolate reductase.	pyrimidine	112-122	dihydrofolate reductase	Gallus gallus	280-303	
3880742-4	1985	One important consequence of this deeper insertion of the pyrimidine into the active site of chicken dihydrofolate reductase is the loss of a potential hydrogen bond that would otherwise form between the carbonyl oxygen of Val-115 and the inhibitor"s 4-amino group.	pyrimidine	58-68	dihydrofolate reductase	Gallus gallus	101-124	
3880743-2	1985	X-ray structural results are reported for 10 triazine and pyrimidine inhibitors of dihydrofolate reductase, each one studied as a ternary complex with NADPH and chicken dihydrofolate reductase.	pyrimidine	58-68	dihydrofolate reductase	Gallus gallus	83-106