PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28177875-6 2017 In addition, by analyzing the metabolic profiles of long-lived germline-less glp-1 mutants, we discovered that glp-1 mutants regulate the levels of many age-variant metabolites to attenuate aging, including elevated concentrations of the pyrimidine and purine metabolism intermediates and decreased concentrations of the citric acid cycle intermediates. pyrimidine 238-248 glp-1/Notch intracellular domain Caenorhabditis elegans 111-116 28177875-7 2017 Interestingly, by analyzing the metabolome of daf-16;glp-1 double mutants, our results revealed that some metabolic exchange contributing to germline-mediated longevity was mediated by transcription factor FOXO/DAF-16, including pyrimidine metabolism and the TCA cycle. pyrimidine 229-239 glp-1/Notch intracellular domain Caenorhabditis elegans 53-58