PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9042911-7 1997 Expression of human UMP synthase cDNAs containing these mutations in pyrimidine auxotrophic Escherichia coli and in recombinant baculovirus-infected Sf21 cells demonstrates impaired activity presumably associated with the urinary orotic acid substrate accumulations observed in vivo. pyrimidine 69-79 uridine monophosphate synthetase Homo sapiens 20-32 1500593-1 1992 Heterozygotes for a deficiency of uridine-5"-monophosphate synthase, a metabolic disease that interferes with pyrimidine biosynthesis, were related to a common ancestor, Skokie Sensation Ned. pyrimidine 110-120 uridine monophosphate synthetase Homo sapiens 34-67 2996510-4 1985 In addition, three compounds, 5-azaorotate, 5-bromoorotate, and barbiturate were also inhibitory against the two subsequent enzymes of the pathway, orotate phosphoribosyltransferase and orotidylate decarboxylase, so that they could act against three enzymes of the mammalian pyrimidine de novo biosynthetic pathway. pyrimidine 275-285 uridine monophosphate synthetase Homo sapiens 148-181 35356460-1 2022 Background: Hereditary orotic aciduria (HOA) is a rare genetic disorder of pyrimidine metabolism caused by variations in the uridine monophosphate synthetase (UMPS) gene and inheritance are autosomal recessive. pyrimidine 75-85 uridine monophosphate synthetase Homo sapiens 125-157 35356460-1 2022 Background: Hereditary orotic aciduria (HOA) is a rare genetic disorder of pyrimidine metabolism caused by variations in the uridine monophosphate synthetase (UMPS) gene and inheritance are autosomal recessive. pyrimidine 75-85 uridine monophosphate synthetase Homo sapiens 159-163 2502942-9 1989 Enzyme deficiencies that directly or indirectly affect pyrimidine metabolism (orotate phosphoribosyltransferase and methionine synthase deficiencies) are exceedingly rare and only inconsistently produce an immune defect (involving T cells). pyrimidine 55-65 uridine monophosphate synthetase Homo sapiens 78-111 35169125-5 2022 UBE2T overexpression led to the upregulation of several key enzymes catalyzing de novo pyrimidine synthesis, including CAD, DHODH, and UMPS. pyrimidine 87-97 uridine monophosphate synthetase Homo sapiens 135-139 26700594-1 2015 Orotate phosphoribosyltransferase (OPRT) is engaged in de novo pyrimidine synthesis. pyrimidine 63-73 uridine monophosphate synthetase Homo sapiens 0-33 32661439-4 2020 Using genome editing methods, we disrupt uridine monophosphate synthetase (UMPS) in the pyrimidine de novo synthesis pathway in cell lines, pluripotent cells and primary human T cells. pyrimidine 88-98 uridine monophosphate synthetase Homo sapiens 41-73 32661439-4 2020 Using genome editing methods, we disrupt uridine monophosphate synthetase (UMPS) in the pyrimidine de novo synthesis pathway in cell lines, pluripotent cells and primary human T cells. pyrimidine 88-98 uridine monophosphate synthetase Homo sapiens 75-79 28847964-8 2017 Moreover, inhibition of MYC target pyrimidine synthesis genes such as CAD, UMPS, and CTPS blocked cell growth, and thus are potential targets for colorectal cancer therapy. pyrimidine 35-45 uridine monophosphate synthetase Homo sapiens 75-79 5032526-1 1972 Allopurinol therapy in man interferes with pyrimidine biosynthesis de novo by inhibition of one or both of the two enzymes, orotate phosphoribosyltransferase (OPRT) and orotidylic decarboxylase (ODC), responsible for the conversion of orotic acid to uridine-5"-monophosphate. pyrimidine 43-53 uridine monophosphate synthetase Homo sapiens 124-157 5032526-1 1972 Allopurinol therapy in man interferes with pyrimidine biosynthesis de novo by inhibition of one or both of the two enzymes, orotate phosphoribosyltransferase (OPRT) and orotidylic decarboxylase (ODC), responsible for the conversion of orotic acid to uridine-5"-monophosphate. pyrimidine 43-53 uridine monophosphate synthetase Homo sapiens 159-163 25112781-1 2015 BACKGROUND: The efficacy of 5-fluorouracil (5FU)-based therapy, which remains the cornerstone of gastrointestinal cancer treatment, depends upon the expression of enzymes involved in pyrimidine metabolism, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), and orotate phosphoribosyltransferase (OPRT). pyrimidine 183-193 uridine monophosphate synthetase Homo sapiens 316-349 25112781-1 2015 BACKGROUND: The efficacy of 5-fluorouracil (5FU)-based therapy, which remains the cornerstone of gastrointestinal cancer treatment, depends upon the expression of enzymes involved in pyrimidine metabolism, including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), and orotate phosphoribosyltransferase (OPRT). pyrimidine 183-193 uridine monophosphate synthetase Homo sapiens 351-355 26700594-1 2015 Orotate phosphoribosyltransferase (OPRT) is engaged in de novo pyrimidine synthesis. pyrimidine 63-73 uridine monophosphate synthetase Homo sapiens 35-39 21367966-1 2011 Uridine-5"-monophosphate synthase (UMPS), the critical step of the de novo pyrimidine biosynthesis pathway, which is a housekeeping plastid process in higher plants, was investigated in a marine diatom, the most crucial primary producer in the marine environment. pyrimidine 75-85 uridine monophosphate synthetase Homo sapiens 35-39 23585020-3 2013 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). pyrimidine 212-222 uridine monophosphate synthetase Homo sapiens 158-172 23585020-3 2013 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). pyrimidine 212-222 uridine monophosphate synthetase Homo sapiens 174-178 21791367-1 2011 INTRODUCTION/BACKGROUND: Pyrimidine antimetabolites" target molecules thymidylate synthase (TS) and flopropyrimidine-metabolising enzymes such as dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyltransferase (OPRT) are known as biomarkers of 5-fluorouracil (5-FU) treatment. pyrimidine 25-35 uridine monophosphate synthetase Homo sapiens 218-251 21791367-1 2011 INTRODUCTION/BACKGROUND: Pyrimidine antimetabolites" target molecules thymidylate synthase (TS) and flopropyrimidine-metabolising enzymes such as dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyltransferase (OPRT) are known as biomarkers of 5-fluorouracil (5-FU) treatment. pyrimidine 25-35 uridine monophosphate synthetase Homo sapiens 253-257 24507637-1 2014 OBJECTIVE: To investigate the multienzyme complex formation of human malaria parasite Plasmodium falciparum (P. falciparum) orotate phosphoribosyltransferase (OPRT) and orotidine 5"-monophosphate decarboxylase (OMPDC), the fifth and sixth enzyme of the de novo pyrimidine biosynthetic pathway. pyrimidine 261-271 uridine monophosphate synthetase Homo sapiens 124-157 24507637-1 2014 OBJECTIVE: To investigate the multienzyme complex formation of human malaria parasite Plasmodium falciparum (P. falciparum) orotate phosphoribosyltransferase (OPRT) and orotidine 5"-monophosphate decarboxylase (OMPDC), the fifth and sixth enzyme of the de novo pyrimidine biosynthetic pathway. pyrimidine 261-271 uridine monophosphate synthetase Homo sapiens 159-163 21631301-1 2011 AIMS: Uridine monophosphate synthase (UMPS) is a fundamental enzyme in pyrimidine synthesis. pyrimidine 71-81 uridine monophosphate synthetase Homo sapiens 6-36 21631301-1 2011 AIMS: Uridine monophosphate synthase (UMPS) is a fundamental enzyme in pyrimidine synthesis. pyrimidine 71-81 uridine monophosphate synthetase Homo sapiens 38-42 21401501-4 2011 Alterations of purine and pyrimidine metabolism affecting brain function are spread along both synthesis (PRPS, ADSL, ATIC, HPRT, UMPS, dGK, TK), and breakdown pathways (5NT, ADA, PNP, GCH, DPD, DHPA, TP, UP), sometimes also involving pyridine metabolism. pyrimidine 26-36 uridine monophosphate synthetase Homo sapiens 130-134 19292447-2 2009 Pyrimidine de novo biosynthesis is required in Plasmodium falciparum , and thus OPRT of the parasite (PfOPRT) is a target for antimalarial drugs. pyrimidine 0-10 uridine monophosphate synthetase Homo sapiens 80-84 15162399-3 2004 After the pyrimidine limitation of a "P. alkanolytica" orotate phosphoribosyltransferase mutant strain grown on succinate, the pyrimidine biosynthetic pathway enzyme activities were derepressed. pyrimidine 10-20 uridine monophosphate synthetase Homo sapiens 55-88 15162399-3 2004 After the pyrimidine limitation of a "P. alkanolytica" orotate phosphoribosyltransferase mutant strain grown on succinate, the pyrimidine biosynthetic pathway enzyme activities were derepressed. pyrimidine 127-137 uridine monophosphate synthetase Homo sapiens 55-88 17513443-6 2007 Increased orotic acid excretion can also arise as a result of impairments of pyrimidine synthesis, whether brought about by a genetic defect (e.g., in UMP synthase) or by drugs that inhibit the terminal part of the pathway (e.g., allopurinol or 6-azauridine). pyrimidine 77-87 uridine monophosphate synthetase Homo sapiens 151-163 15683248-2 2005 The parasite"s orotate phosphoribosyltransferase (PfOPRT) and orotidine 5"-monophosphate decarboxylase (PfOMPDC) of the de novo pyrimidine pathway are attractive targets for antimalarial drug development. pyrimidine 128-138 uridine monophosphate synthetase Homo sapiens 15-48 15060742-9 2004 The gene expression of TS and OPRT, which are involved in de novo pyrimidine synthesis, and that of DPD and TP, may be coregulated. pyrimidine 66-76 uridine monophosphate synthetase Homo sapiens 30-34 10891536-6 2000 Analysis of enzyme activities and gene expression associated with pyrimidine metabolism indicated that a significant decrease in orotate phosphoribosyltransferase activity in DLD-1/5-FU cells, a 7-fold increase of TS mRNA in DLD-1/FdUrd cells, and a 37-fold decrease in thymidine kinase activity of DLD-1/F3(d)Thd cells were the major mechanisms of drug resistance. pyrimidine 66-76 uridine monophosphate synthetase Homo sapiens 129-162