PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24063363-6 2013 Previous studies show that N-glycosidic bond hydrolysis follows a stepwise (S(N)1) mechanism, and that TDG activity increases with pyrimidine N1 acidity, that is, leaving group quality of the target base. pyrimidine 131-141 thymine DNA glycosylase Homo sapiens 103-106 35436101-1 2022 Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases. pyrimidine 199-209 thymine DNA glycosylase Homo sapiens 0-23 12119040-10 2002 Finally, the base 5" to the mismatched G in the G:T mispair conferred sequence preference on the A1235 extract in the presence of ATP and TDG, with a pyrimidine (especially cytosine) being much favored over a purine. pyrimidine 150-160 thymine DNA glycosylase Homo sapiens 138-141 35436101-1 2022 Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU), and many other oxidized and halogenated pyrimidine bases. pyrimidine 199-209 thymine DNA glycosylase Homo sapiens 25-28