PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22029285-3 2011 In this work, we tested the hypothesis if addition of a positively ionizable group (PI) to the pyrimidine ring of the scaffold members in positions 5, 6, or 7 could further increase their 5HT(6)R blocking potency. pyrimidine 95-105 5-hydroxytryptamine receptor 6 Homo sapiens 188-195