PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34462431-3	2021	Here we report that the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is an attractive therapeutic target for MYCN-amplified neuroblastoma, a childhood cancer with poor prognosis.	pyrimidine	24-34	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	132-136	
34462431-4	2021	Gene expression profiling and metabolomic analysis reveal that MYCN promotes pyrimidine nucleotide production by transcriptional upregulation of DHODH and other enzymes of the pyrimidine-synthesis pathway.	pyrimidine	176-186	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	63-67	
34009981-2	2021	Here, we describe the design and synthesis of a series of pyrimidine-based derivatives able to inhibit Aurora A kinase activity and reduce levels of cMYC and MYCN.	pyrimidine	58-68	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	158-162