PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33507295-7 2021 Mechanistically, compared with KPT-330 alone, K+CS suppresses the expression of CRM1, Rad51, and thymidylate synthase proteins, leading to more efficient inhibition of CRM1-mediated nuclear export, impairment of DNA-damage repair, reduced pyrimidine synthesis, cell-cycle arrest in S-phase, and cell apoptosis. pyrimidine 239-249 exportin 1 Mus musculus 80-84