PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21591611-4 2011 Interestingly, the pyrimidine ring including the thioether of 1 could be replaced by a simple benzyl or a benzylidene moiety yielding a novel series of bioactive 2-benzylidene- and 2-benzylhexanoic acids exemplified by 2-(2,3-diphenethoxybenzylidene)hexanoic acid, 29 (IC(50) 5-LO = 0.8 muM; mPGES-1 = 1.1 muM). pyrimidine 19-29 prostaglandin E synthase Mus musculus 292-299