PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27912175-1	2017	A new series of diphenylpyrimidine derivatives (DPPYs) bearing various aniline side chains at the C-2 position of pyrimidine core were synthesized as potent BTK inhibitors.	pyrimidine	24-34	Bruton tyrosine kinase	Homo sapiens	157-160	
29146136-2	2018	Here we report the identification of several classes of pyrimidine derivatives as potent BTK and JAK3 dual inhibitors.	pyrimidine	56-66	Bruton tyrosine kinase	Homo sapiens	89-92	
29146136-4	2018	Additionally, these pyrimidine derivatives also exhibited enhanced activity to block the proliferation of B-cell lymphoma cells compared with the representative BTK inhibitor ibrutinib.	pyrimidine	20-30	Bruton tyrosine kinase	Homo sapiens	161-164	
31843459-6	2020	These explorations offered new clues to discover benzoxaborole fragment and pyrimidine scaffold as more effective BTK and JAK3 dual inhibitors.	pyrimidine	76-86	Bruton tyrosine kinase	Homo sapiens	114-117	
30006143-7	2018	All these findings provided new clues about the pyrimidine scaffold as an effective BTK inhibitor for the treatment of B-cell lymphoma.	pyrimidine	48-58	Bruton tyrosine kinase	Homo sapiens	84-87	
27912175-6	2017	These explorations provided new clues to discover pyrimidine scaffold as more effective BTK inhibitors.	pyrimidine	50-60	Bruton tyrosine kinase	Homo sapiens	88-91	
27994736-1	2016	Based on the pyrimidine skeleton of EGFRT790M inhibitors, a series of N,9-diphenyl-9H-purin-2-amine derivatives were identified as effective BTK inhibitors.	pyrimidine	13-23	Bruton tyrosine kinase	Homo sapiens	141-144	
25906044-2	2015	In this study, two- and three-dimensional quantitative structure-activity relationship (2D and 3D-QSAR) analyses were performed on a series of pyridine and pyrimidine-based BTK inhibitors by means of genetic algorithm optimized multivariate adaptive regression spline (GA-MARS) and comparative molecular similarity index analysis (CoMSIA) methods.	pyrimidine	156-166	Bruton tyrosine kinase	Homo sapiens	173-176	
25906044-7	2015	Twenty-five pyridine and pyrimidine derivatives as novel potential BTK inhibitors were finally selected for further study.	pyrimidine	25-35	Bruton tyrosine kinase	Homo sapiens	67-70	
27210433-3	2016	The preliminary structure-activity relationship was discussed and the primary amino group at the C-4 position of pyrimidine was crucial for maintaining BTK activity.	pyrimidine	113-123	Bruton tyrosine kinase	Homo sapiens	152-155