PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29601948-7 2018 Specifically, upregulated RNA polymerase I subunit B (POLR1B), DNA polymerase epsilon 3, accessory subunit (POLE3), and DNA polymerase delta 3, accessory subunit (POLD3) were enriched in pathway of pyrimidine metabolism associated with obesity and PCOS, and 5-hydroxytryptamine receptor 2C (HTR2C) was enriched calcium signaling pathway. pyrimidine 198-208 5-hydroxytryptamine receptor 2C Homo sapiens 258-289 31491978-1 2019 Here, we describe the synthesis of disubstituted pyrimidine derivatives and their biological evaluation as selective 5-HT2C agonists. pyrimidine 49-59 5-hydroxytryptamine receptor 2C Homo sapiens 117-123 31491978-5 2019 Thus, pyrimidine 10a could be considered a viable lead compound as a 5-HT2C selective agonist. pyrimidine 6-16 5-hydroxytryptamine receptor 2C Homo sapiens 69-75 29601948-9 2018 CONCLUSIONS: In conclusion, POLR1B, POLE3, POLD3, and HTR2C might play important roles in obese PCOS via involvement of pyrimidine metabolism and calcium signaling pathway. pyrimidine 120-130 5-hydroxytryptamine receptor 2C Homo sapiens 54-59 29601948-7 2018 Specifically, upregulated RNA polymerase I subunit B (POLR1B), DNA polymerase epsilon 3, accessory subunit (POLE3), and DNA polymerase delta 3, accessory subunit (POLD3) were enriched in pathway of pyrimidine metabolism associated with obesity and PCOS, and 5-hydroxytryptamine receptor 2C (HTR2C) was enriched calcium signaling pathway. pyrimidine 198-208 5-hydroxytryptamine receptor 2C Homo sapiens 291-296