PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9825701-7 1998 This indicates that irreversible events in the signaling pathway of apoptosis occur in the period between irradiation and photoreactivation even in the presence of high levels of Bcl-2 protein can delay the onset of UV-induced apoptosis in these marsupial cells, early events triggered by the pyrimidine dimers, upstream from the Bcl-2 action, lead the cell to a state committed to die. pyrimidine 293-303 BCL2 apoptosis regulator Homo sapiens 179-184 15294893-4 2004 The specificity of the CA repeats in terms of destabilizing bcl-2 mRNA was proven by the substituting the CA repeats with other alternative repeats of purine/pyrimidine, but this had no effect on the stability of bcl-2 mRNA. pyrimidine 158-168 BCL2 apoptosis regulator Homo sapiens 60-65 2176281-6 1990 Here we demonstrate that the breakpoints at the 5" flanking region of bcl-2 gene are surrounded by multiple alternating purine-pyrimidine elements (potential Z-DNA). pyrimidine 127-137 BCL2 apoptosis regulator Homo sapiens 70-75 31302150-6 2019 Our findings indicate that enzymes of the rate-limiting steps of pyrimidine and purine biosynthesis, the pro-viral MCL1 apoptosis regulator, BCL2 family member protein and the mitochondrial electron transport complex III, play critical roles in the completion of the mammarenavirus life cycle, suggesting they represent potential druggable targets to counter human pathogenic mammarenavirus infections. pyrimidine 65-75 BCL2 apoptosis regulator Homo sapiens 141-145