PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 5032526-1 1972 Allopurinol therapy in man interferes with pyrimidine biosynthesis de novo by inhibition of one or both of the two enzymes, orotate phosphoribosyltransferase (OPRT) and orotidylic decarboxylase (ODC), responsible for the conversion of orotic acid to uridine-5"-monophosphate. pyrimidine 43-53 ornithine decarboxylase 1 Homo sapiens 169-193 5032526-1 1972 Allopurinol therapy in man interferes with pyrimidine biosynthesis de novo by inhibition of one or both of the two enzymes, orotate phosphoribosyltransferase (OPRT) and orotidylic decarboxylase (ODC), responsible for the conversion of orotic acid to uridine-5"-monophosphate. pyrimidine 43-53 ornithine decarboxylase 1 Homo sapiens 195-198