PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18410127-4	2008	Biochemical studies demonstrate that RPA efficiently melts an intermolecular DNA triple helix consisting of a pyrimidine motif third strand annealed to a 4 kb duplex DNA fragment at protein concentrations equimolar to the triplex substrate.	pyrimidine	110-120	replication protein A1	Homo sapiens	37-40	
21772997-4	2011	Binding studies show that RPA-C binds pyrimidine- and purine-rich sequences similarly.	pyrimidine	38-48	replication protein A1	Homo sapiens	26-29	
19187036-4	2009	Moreover, hRPA binds to a 26-mer purine-rich quadruplex-forming sequence with an affinity indistinguishable from that for binding to the complementary pyrimidine-rich sequence.	pyrimidine	151-161	replication protein A1	Homo sapiens	10-14	
19187036-6	2009	Thus, DNA secondary structures can significantly modulate the binding affinity of hRPA over and above its known preference for pyrimidine-rich single-stranded sequences, so that at least some intramolecular G-quadruplex structures may not inhibit hRPA binding during DNA replication.	pyrimidine	127-137	replication protein A1	Homo sapiens	82-86	
1320195-10	1992	Both yeast and human RP-A bind preferentially to the pyrimidine-rich strand of a homologous origin of replication: the ARS307 or the simian virus 40 origin of replication, respectively.	pyrimidine	53-63	replication protein A1	Homo sapiens	21-25	
34137442-4	2021	IGF-I treatment, in the presence of signalling inhibitors, particularly TDRL-505, which targets replication protein A (RPA), impaired activation of IGF-1R downstream signalling, diminished cyclobutane pyrimidine dimer removal, arrested growth, reduced cell survival and increased apoptosis.	pyrimidine	201-211	replication protein A1	Homo sapiens	96-117	
34137442-4	2021	IGF-I treatment, in the presence of signalling inhibitors, particularly TDRL-505, which targets replication protein A (RPA), impaired activation of IGF-1R downstream signalling, diminished cyclobutane pyrimidine dimer removal, arrested growth, reduced cell survival and increased apoptosis.	pyrimidine	201-211	replication protein A1	Homo sapiens	119-122