PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34376225-7 2021 The identified Ref-1"s role in mitochondrial function was confirmed using mitochondrial function assays, qRT-PCR, western blotting and NADP assay. NADP 135-139 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 15-20 8604436-2 1995 Redox signalling pathways provide a link between external stimuli, through the flavoenzyme-mediated NADPH-dependent reduction of intracellular peptide thiols, such as glutathione, thioredoxin, glutaredoxin, and redox factor-1, to the posttranslational redox modification of certain intracellular proteins. NADP 100-105 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 211-225 34376225-12 2021 In Ref-1 knockdown cells, a higher flux rate of NADP + consuming reactions was observed suggesting the less availability of NADP + and a higher level of oxidative stress in these cells. NADP 48-54 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 3-8 34376225-12 2021 In Ref-1 knockdown cells, a higher flux rate of NADP + consuming reactions was observed suggesting the less availability of NADP + and a higher level of oxidative stress in these cells. NADP 124-130 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 3-8 31951764-0 2020 APX-115A, a pan-NADPH oxidase inhibitor, induces caspase-dependent cell death by suppressing NOX4-ROS signaling in EBV-infected retinal epithelial cells. NADP 16-21 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 0-3