PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24467670-6	2014	P5CR was able to use either NADPH or NADH as the electron donor, with contrasting affinities and maximum reaction rates.	NADP	28-33	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-4	
28258219-6	2017	Structures of binary complexes of PYCR1 with NADPH or proline determined at 1.9 A resolution provide insight into cofactor and substrate recognition.	NADP	45-50	pyrroline-5-carboxylate reductase 1	Homo sapiens	34-39	
28258219-8	2017	The 1.85 A resolution structure of a ternary complex containing NADPH and a P5C/proline analog provides a model of the Michaelis complex formed during hydride transfer.	NADP	64-69	pyrroline-5-carboxylate reductase 1	Homo sapiens	76-79	
28194412-1	2017	Pyrroline-5-carboxylate reductase (P5CR1) is a universal housekeeping enzyme that catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)+.	NADP	198-205	pyrroline-5-carboxylate reductase 1	Homo sapiens	115-139	
28194412-1	2017	Pyrroline-5-carboxylate reductase (P5CR1) is a universal housekeeping enzyme that catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)+.	NADP	198-205	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-38	
31108370-2	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomitant generation of NAD+ and NADP+.	NADP	172-177	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-35	
31108370-2	2019	Pyrroline-5-carboxylate reductase 1 (PYCR1) participates in proline synthesis process by catalyzing the reduction of P5C to proline with concomitant generation of NAD+ and NADP+.	NADP	172-177	pyrroline-5-carboxylate reductase 1	Homo sapiens	37-42	
34107832-5	2021	The 3.5-dibromophenyl- and 3.5-dichlorophenyl-derivatives showed a remarkable effectiveness, with IC50 values lower than 1 microM and a mechanism of competitive type against both P5C and NADPH.	NADP	187-192	pyrroline-5-carboxylate reductase 1	Homo sapiens	179-182	
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	NADP	157-166	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-33	
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	NADP	157-166	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-39	
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	NADP	157-166	pyrroline-5-carboxylate reductase 1	Homo sapiens	74-98	
16600630-1	2006	Pyrroline-5-carboxylate reductase (P5CR) catalyzes the reduction of Delta1-pyrroline-5-carboxylate (P5C) to proline with concomitant oxidation of NAD(P)H to NAD(P)(+).	NADP	157-166	pyrroline-5-carboxylate reductase 1	Homo sapiens	35-38	
16233902-8	2005	Comparison of the native structure of P5CR to structures complexed with L-proline and NADP+ in two quite different primary sequence backgrounds provides unique information about key functional features: the active site and the catalytic mechanism.	NADP	86-91	pyrroline-5-carboxylate reductase 1	Homo sapiens	38-42