PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27901115-6	2016	Interestingly, although p53-mediated suppression of PFKFB3 could increase the two major PPP products, NADPH and nucleotides, only nucleotide production was essential to promote DDR.	NADP	102-107	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	52-58	
26537442-6	2016	We have recently uncovered that stress-inducible CO in and around cancer cells suppresses CBS to result in decreased methylation of PFKFB3, the enzyme regulating PFK-1, leading to a shift of glucose biotransformation from glycolysis toward pentose phosphate pathway; such a metabolic remodeling causes chemoresistance through increasing NADPH and reduced glutathione under stress conditions for cancer cells.	NADP	337-342	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	132-138