PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17884809-2 2007 Our previous studies on structural organization and enzymatic properties of rat FDH suggest that the overall enzyme reaction, i.e. NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO(2), consists of two steps: (i) hydrolytic cleavage of the formyl group in the N-terminal catalytic domain, followed by (ii) NADP(+)-dependent oxidation of the formyl group to CO(2) in the C-terminal aldehyde dehydrogenase domain. NADP 131-138 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 80-83 17884809-2 2007 Our previous studies on structural organization and enzymatic properties of rat FDH suggest that the overall enzyme reaction, i.e. NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO(2), consists of two steps: (i) hydrolytic cleavage of the formyl group in the N-terminal catalytic domain, followed by (ii) NADP(+)-dependent oxidation of the formyl group to CO(2) in the C-terminal aldehyde dehydrogenase domain. NADP 340-347 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 80-83 17302434-1 2007 10-Formyltetrahydrofolate dehydrogenase (FDH) catalyzes an NADP+-dependent dehydrogenase reaction resulting in conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. NADP 59-63 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 0-39 17302434-1 2007 10-Formyltetrahydrofolate dehydrogenase (FDH) catalyzes an NADP+-dependent dehydrogenase reaction resulting in conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. NADP 59-63 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 41-44 17302434-3 2007 In addition to participation in the overall FDH mechanism, the C-terminal domain is capable of NADP+-dependent oxidation of short chain aldehydes to their corresponding acids. NADP 95-100 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 44-47 17302434-4 2007 We have determined the crystal structure of the C-terminal domain of FDH and its complexes with oxidized and reduced forms of NADP. NADP 126-130 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 69-72 17302434-5 2007 Compared to other members of the ALDH family, FDH demonstrates a new mode of binding of the 2"-phosphate group of NADP via a water-mediated contact with Gln600 that may contribute to the specificity of the enzyme for NADP over NAD. NADP 114-118 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 46-49 17302434-5 2007 Compared to other members of the ALDH family, FDH demonstrates a new mode of binding of the 2"-phosphate group of NADP via a water-mediated contact with Gln600 that may contribute to the specificity of the enzyme for NADP over NAD. NADP 217-221 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 46-49 7646059-7 1995 Disulfiram, a potent inhibitor of cytosolic ALDH, inhibited NADP(+)-dependent propanal oxidation by 10-FTHFDH. NADP 60-67 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 100-109 9092577-1 1997 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (FDH) (EC 1.5.1.6) catalyzes two reactions: the NADP+-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP+-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 116-121 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 28-67 9092577-1 1997 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (FDH) (EC 1.5.1.6) catalyzes two reactions: the NADP+-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP+-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 116-121 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 69-72 9092577-1 1997 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (FDH) (EC 1.5.1.6) catalyzes two reactions: the NADP+-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP+-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 207-212 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 28-67 9092577-1 1997 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (FDH) (EC 1.5.1.6) catalyzes two reactions: the NADP+-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP+-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 207-212 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 69-72 9092577-12 1997 NAD+ at physiological concentrations stimulated the aldehyde dehydrogenase reaction performed by FDH or its COOH-terminal domain using NADP+. NADP 135-140 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 97-100 7646059-1 1995 10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate. NADP 79-83 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 0-39 7646059-1 1995 10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate. NADP 79-83 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 48-51 7646059-1 1995 10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate. NADP 201-205 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 0-39 7646059-1 1995 10-Formyltetrahydrofolate dehydrogenase (10-FTH-FDH: EC 1.5.1.6) catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate (10-HCO-H4PteGlu) to tetrahydrofolate (H4PteGlu) and CO2 and the NADP(+)-independent hydrolytic cleavage of 10-HCO-H4PteGlu to H4PteGlu and formate. NADP 201-205 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 48-51 7646059-3 1995 10-FTHFDH catalyzed NADP(+)-dependent oxidation of propanal and the hydrolysis of p-nitrophenyl acetate (pNPA) in a similar fashion to ALDH. NADP 20-27 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 0-9 7646059-11 1995 NADP(+)-dependent oxidation of 10-HCO-H4PteGlu by 10-FTHFDH was inhibited by the folate anti-metabolite, 5,10-dideazatetrahydrofolate, a known GAR-TF inhibitor. NADP 0-7 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 50-59 8527931-1 1995 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes two reactions: the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 122-129 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 28-67 8527931-1 1995 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes two reactions: the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 122-129 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 69-78 8527931-1 1995 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes two reactions: the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 215-222 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 28-67 8527931-1 1995 The liver cytosolic enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes two reactions: the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 215-222 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 69-78 7929148-1 1994 10-Formyltetrahydrofolate dehydrogenase catalyzes the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to CO2 and tetrahydrofolate. NADP 54-61 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 0-39 7822273-1 1995 The enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes both the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 96-103 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 12-51 7822273-1 1995 The enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes both the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 96-103 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 53-62 7822273-1 1995 The enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes both the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 189-196 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 12-51 7822273-1 1995 The enzyme, 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) (EC 1.5.1.6) catalyzes both the NADP(+)-dependent oxidation of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 and the NADP(+)-independent hydrolysis of 10-formyltetrahydrofolate to tetrahydrofolate and formate. NADP 189-196 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 53-62 35013550-1 2022 Putative tumor suppressor ALDH1L1, the product of natural fusion of three unrelated genes, regulates folate metabolism by catalyzing NADP+-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. NADP 133-138 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 26-33 3392008-1 1988 10-Formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) catalyzes the NADP-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2. NADP 67-71 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 0-39