PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11333262-6	2001	In a cell-free system, a fusion protein, p67N-p47N, had an 8-fold higher efficiency and produced a higher activity than the individual proteins, and also resulted in an 8-fold improved efficiency for Rac and a lowered K(m) for NADPH.	NADP	227-232	AKT serine/threonine kinase 1	Homo sapiens	200-203	
11705402-8	2001	The enzyme activity reconstituted with 67N-rac showed a 10-fold higher stability and a lower K(m) for NADPH than the individual components.	NADP	102-107	AKT serine/threonine kinase 1	Homo sapiens	43-46	
15123662-3	2004	We recently demonstrated that NADPH oxidase activation involves sequential interactions between Rac and the flavocytochrome b(558) and p67(phox) oxidase components to regulate electron transfer from NADPH to molecular oxygen.	NADP	30-35	AKT serine/threonine kinase 1	Homo sapiens	96-99	
7618083-4	1995	Native and recombinant PAKs phosphorylated the p47phox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner.	NADP	63-106	AKT serine/threonine kinase 1	Homo sapiens	138-141	
8036496-2	1994	Upon stimulation of phagocytic cells, Rac enhances the activity of the enzyme nicotinamide adenine dinucleotide phosphate (reduced) (NADPH) oxidase, resulting in the production of superoxide radicals.	NADP	78-121	AKT serine/threonine kinase 1	Homo sapiens	38-41	
31729001-1	2020	The superoxide (O2  -)-generating NADPH oxidase complex of phagocytes comprises a membrane-associated heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of NOX2 and p22phox) and four cytosolic regulatory proteins, p47phox, p67phox, p40phox, and the small GTPase Rac.	NADP	34-39	AKT serine/threonine kinase 1	Homo sapiens	280-283	
29669855-6	2018	SQLE increased the NADP+/NADPH (reduced form of NADP+) ratio, which triggered a cascade of events involving oxidative stress-induced DNA methyltransferase 3A (DNMT3A) expression, DNMT3A-mediated epigenetic silencing of PTEN, and activation of AKT-mTOR (mammalian target of rapamycin).	NADP	19-24	AKT serine/threonine kinase 1	Homo sapiens	243-246	
30846598-0	2019	Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase.	NADP	22-27	AKT serine/threonine kinase 1	Homo sapiens	46-49	
30846598-2	2019	We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-Akt pathway induces acute synthesis of NADP+ and NADPH.	NADP	121-126	AKT serine/threonine kinase 1	Homo sapiens	82-85	
30846598-2	2019	We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-Akt pathway induces acute synthesis of NADP+ and NADPH.	NADP	131-136	AKT serine/threonine kinase 1	Homo sapiens	82-85	
30846598-3	2019	Akt phosphorylates NAD kinase (NADK), the sole cytosolic enzyme that catalyzes the synthesis of NADP+ from NAD+ (the oxidized form of NADH), on three serine residues (Ser44, Ser46, and Ser48) within an amino-terminal domain.	NADP	96-101	AKT serine/threonine kinase 1	Homo sapiens	0-3	
30846598-6	2019	These data indicate that Akt-mediated phosphorylation of NADK stimulates its activity to increase NADP+ production through relief of an autoinhibitory function inherent to its amino terminus.	NADP	98-103	AKT serine/threonine kinase 1	Homo sapiens	25-28	
29669855-6	2018	SQLE increased the NADP+/NADPH (reduced form of NADP+) ratio, which triggered a cascade of events involving oxidative stress-induced DNA methyltransferase 3A (DNMT3A) expression, DNMT3A-mediated epigenetic silencing of PTEN, and activation of AKT-mTOR (mammalian target of rapamycin).	NADP	25-30	AKT serine/threonine kinase 1	Homo sapiens	243-246	
21461238-5	2011	NAD(+) and NADP(+) activated protein kinase C and enhanced phosphorylation of mitogen-activated protein kinases and Akt.	NADP	11-15	AKT serine/threonine kinase 1	Homo sapiens	116-119	
24458280-0	2014	Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis.	NADP	27-32	AKT serine/threonine kinase 1	Homo sapiens	0-3	
29231906-2	2017	Specifically, energy restriction in quiescent cells (ERiQ) through energetic perturbations causes adaptive changes in response to reduced ATP, NAD+ and NADP levels in a regulatory network spanned by AKT, NF-kappaB, p53 and mTOR.	NADP	152-156	AKT serine/threonine kinase 1	Homo sapiens	199-202	
21461238-6	2011	NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride.	NADP	12-19	AKT serine/threonine kinase 1	Homo sapiens	102-105