PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20697932-0 2010 The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase. NADP 45-52 glutamate dehydrogenase 1 Homo sapiens 68-91 23420347-1 2013 Glutamate dehydrogenase (GDH) uses ammonia to reversibly convert alpha-ketoglutarate to glutamate using NADP(H) and NAD(H) as cofactors. NADP 104-111 glutamate dehydrogenase 1 Homo sapiens 0-23 23420347-1 2013 Glutamate dehydrogenase (GDH) uses ammonia to reversibly convert alpha-ketoglutarate to glutamate using NADP(H) and NAD(H) as cofactors. NADP 104-111 glutamate dehydrogenase 1 Homo sapiens 25-28 22155552-3 2012 Although it was a dual co-factor GDH, activity was greater with NAD(+)/H than with NADP(+)/H. NADP 83-90 glutamate dehydrogenase 1 Homo sapiens 33-36 22052482-9 2012 Mammalian GDH exhibits negative cooperativity with respect to binding of NAD and NADPH coenzyme molecules, activation by ADP, and inhibition by GTP. NADP 81-86 glutamate dehydrogenase 1 Homo sapiens 10-13 20697932-1 2010 Glutamate dehydrogenase (GDH) from vertebrates is unusual among NAD(P)H-dependent dehydrogenases in that it can use either NAD(H) or NADP(H) as cofactor. NADP 133-140 glutamate dehydrogenase 1 Homo sapiens 0-23 20697932-1 2010 Glutamate dehydrogenase (GDH) from vertebrates is unusual among NAD(P)H-dependent dehydrogenases in that it can use either NAD(H) or NADP(H) as cofactor. NADP 133-140 glutamate dehydrogenase 1 Homo sapiens 25-28 20697932-3 2010 Methods for both reaction directions were developed, and for the first time, to our knowledge, the GDH activity has been simultaneously studied in the presence of both NAD(H) and NADP(H). NADP 179-186 glutamate dehydrogenase 1 Homo sapiens 99-102 20697932-4 2010 Our data indicate that NADP(H) has inhibitory effects on the rate of NAD(H) utilization by GDH, a characteristic of GDH not previously recognized. NADP 23-30 glutamate dehydrogenase 1 Homo sapiens 91-94 20697932-4 2010 Our data indicate that NADP(H) has inhibitory effects on the rate of NAD(H) utilization by GDH, a characteristic of GDH not previously recognized. NADP 23-30 glutamate dehydrogenase 1 Homo sapiens 116-119 20697932-5 2010 The response of GDH to allosteric activators in the presence of NAD(H) and NADP(H) suggests that ADP and leucine moderate much of the inhibitory effect of NADP(H) on the utilization of NAD(H). NADP 75-82 glutamate dehydrogenase 1 Homo sapiens 16-19 20697932-5 2010 The response of GDH to allosteric activators in the presence of NAD(H) and NADP(H) suggests that ADP and leucine moderate much of the inhibitory effect of NADP(H) on the utilization of NAD(H). NADP 155-162 glutamate dehydrogenase 1 Homo sapiens 16-19 17531229-6 2007 NADH and NADPH, but not NAD or NADP, can also replace NTP, suggesting that the NAD(P)H-binding-pocket configuration of the GDH contacts the RNA. NADP 9-14 glutamate dehydrogenase 1 Homo sapiens 123-126 19531491-1 2009 Mammalian glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l-glutamate to 2-oxoglutarate using NAD(P)(+) as coenzyme. NADP 157-166 glutamate dehydrogenase 1 Homo sapiens 10-33 19531491-1 2009 Mammalian glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l-glutamate to 2-oxoglutarate using NAD(P)(+) as coenzyme. NADP 157-166 glutamate dehydrogenase 1 Homo sapiens 35-38 18502113-6 2008 Furthermore, we found the photovoltaic effect of CNTs/CdS/GDH can trigger the dehydrogenase enzymatic reaction in the absence of the NAD(+) or NADP(+) cofactors. NADP 143-150 glutamate dehydrogenase 1 Homo sapiens 58-61 17531229-6 2007 NADH and NADPH, but not NAD or NADP, can also replace NTP, suggesting that the NAD(P)H-binding-pocket configuration of the GDH contacts the RNA. NADP 9-13 glutamate dehydrogenase 1 Homo sapiens 123-126 15878595-4 2005 The NADP-dependent glutamate dehydrogenase (GDH) of P.falciparum is largely responsible for the production of NADPH in the parasite, which in turn serves as electron source for the antioxidative enzymes glutathione reductase and thioredoxin reductase. NADP 110-115 glutamate dehydrogenase 1 Homo sapiens 44-47 11746417-1 2001 Glutamate dehydrogenase (GDH) catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate using NAD or NADP as cofactors. NADP 115-119 glutamate dehydrogenase 1 Homo sapiens 0-23 15050973-2 2004 GDH catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate plus ammonia, using NAD or NADP as co-factor. NADP 103-107 glutamate dehydrogenase 1 Homo sapiens 0-3 11746417-1 2001 Glutamate dehydrogenase (GDH) catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate using NAD or NADP as cofactors. NADP 115-119 glutamate dehydrogenase 1 Homo sapiens 25-28 2604038-2 1989 For instance, alpha-KG formed from Glu by AspAT is reduced and aminated back to Glu by GDH, which oxidizes NADPH corresponding to the amount of alpha-KG formed. NADP 107-112 glutamate dehydrogenase 1 Homo sapiens 87-90 2573605-5 1989 The Km values of the patients" GDH for alpha-ketoglutarate, glutamate, NADH, and NADPH were significantly increased as compared to GDH obtained from normal and neurologic control subjects. NADP 81-86 glutamate dehydrogenase 1 Homo sapiens 31-34 10402763-1 1999 We describe the separation of an active glutamate dehydrogenase [GDH (NADP+)] enzyme from the plasma of patients with P. falciparum infection using columns of sepharose anti-GDH (NADP+) of Proteus spp. NADP 70-74 glutamate dehydrogenase 1 Homo sapiens 65-68 10402763-4 1999 The differential inhibition of the P. falciparum GDH (NADP+) indicates that some epitopes recognised by the antibodies in both preparations may be different. NADP 54-58 glutamate dehydrogenase 1 Homo sapiens 49-52 10402763-5 1999 The determination of P. falciparum GDH (NADP+) activity could be developed into a specific technique for the diagnosis of falciparum malaria. NADP 40-45 glutamate dehydrogenase 1 Homo sapiens 35-38 1722841-1 1991 A sensitive bioluminescent rapid method for estimating the activity of pyridine nucleotide-(phosphate)-dependent glutamate dehydrogenases (NAD(P)-GDH) of human peripheral blood lymphocytes is suggested. NADP 139-145 glutamate dehydrogenase 1 Homo sapiens 146-149 1722841-4 1991 The findings evidence the diagnostic significance of NAD(P)-GDH for the detection of subjects at risk of developing acute respiratory diseases. NADP 53-59 glutamate dehydrogenase 1 Homo sapiens 60-63 2604038-3 1989 In the reverse reaction, Glu formed from alpha-KG is oxidized and deaminated back to alpha-KG by GDH, which reduces NADP+ corresponding to the amount of Glu formed. NADP 116-120 glutamate dehydrogenase 1 Homo sapiens 97-100 29438976-1 2018 Glutamate dehydrogenase (Gdh) plays a central role in ammonia detoxification by catalysing reversible oxidative deamination of l-glutamate into alpha-ketoglutarate using NAD+ or NADP+ as cofactor. NADP 178-183 glutamate dehydrogenase 1 Homo sapiens 25-28 6502134-4 1984 This bacterial GDH was predominantly NAD+-linked, but was able to utilize both NADP+ and NADPH at 4% of the rates with NAD+ and NADH, respectively. NADP 79-84 glutamate dehydrogenase 1 Homo sapiens 15-18 6502134-4 1984 This bacterial GDH was predominantly NAD+-linked, but was able to utilize both NADP+ and NADPH at 4% of the rates with NAD+ and NADH, respectively. NADP 89-94 glutamate dehydrogenase 1 Homo sapiens 15-18 18551483-1 1983 Oocystis sp., a unicellular green alga, contained two glutamate dehydrogenase isoenzymes: one was specific for NADH and the other for NADPH. NADP 134-139 glutamate dehydrogenase 1 Homo sapiens 54-77 18551483-2 1983 Activity staining after gel electrophoresis indicated that one component in NADH-GDH was not specific for the cofactor and three components in NADPH-GDH. NADP 143-148 glutamate dehydrogenase 1 Homo sapiens 81-84 18551483-2 1983 Activity staining after gel electrophoresis indicated that one component in NADH-GDH was not specific for the cofactor and three components in NADPH-GDH. NADP 143-148 glutamate dehydrogenase 1 Homo sapiens 149-152 18551483-5 1983 There was a sharp increase in NADPH-GDH activity following the exhaustion of ammonia from the medium but NADH-GDH activity remained unchanged. NADP 30-35 glutamate dehydrogenase 1 Homo sapiens 36-39 18551483-6 1983 The NADPH-GDH activity at the outset increased exponentially with time in greenhouse culture but then decreased sharply accompanied by a rapid increase in biomass and nitrite concentration. NADP 4-9 glutamate dehydrogenase 1 Homo sapiens 10-13 18551483-7 1983 The K(m) values for ammonia in this algal GDH was high, while glutamate synthase activity was not detected; this suggests that Oocystis may adapt to conditions of ammonia limitation by producing large quantities of NADPH-GDH instead of using glutamate synthase pathway. NADP 215-220 glutamate dehydrogenase 1 Homo sapiens 42-45 18551483-7 1983 The K(m) values for ammonia in this algal GDH was high, while glutamate synthase activity was not detected; this suggests that Oocystis may adapt to conditions of ammonia limitation by producing large quantities of NADPH-GDH instead of using glutamate synthase pathway. NADP 215-220 glutamate dehydrogenase 1 Homo sapiens 221-224 33868388-12 2021 Thus, a p53/p21-dependent change in partitioning of the glutamate conversion to 2-oxoglutarate through GOT2 or GDH, linked to NAD(P)-dependent metabolism of 2-oxoglutarate in affiliated pathways, adapts A549 cells to thiamine deficiency or cisplatin treatment. NADP 126-132 glutamate dehydrogenase 1 Homo sapiens 111-114 30583861-6 2019 Furthermore, biochemical analysis showed that NADP+ had high affinity (Kd of 77 nM) for GDH; by targeting the NADP binding site, propylselen effectively inhibited both E. coli and human GDH activity and improved anticancer activity. NADP 46-51 glutamate dehydrogenase 1 Homo sapiens 186-189 30583861-6 2019 Furthermore, biochemical analysis showed that NADP+ had high affinity (Kd of 77 nM) for GDH; by targeting the NADP binding site, propylselen effectively inhibited both E. coli and human GDH activity and improved anticancer activity. NADP 46-50 glutamate dehydrogenase 1 Homo sapiens 186-189 28208702-1 2017 Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible conversion of glutamate to alpha-ketoglutarate and ammonia while reducing NAD(P)+ to NAD(P)H. NADP 156-163 glutamate dehydrogenase 1 Homo sapiens 0-23 28208702-11 2017 In steroid producing cells, hGDH1/2 is thought to generate reducing equivalents (NADPH) in the mitochondria for the biosynthesis of steroidal hormones. NADP 81-86 glutamate dehydrogenase 1 Homo sapiens 28-35 29470101-5 2018 The recombinant human GDH enzyme showed expected properties such as adenosine diphosphate activation and nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate dual recognition. NADP 139-182 glutamate dehydrogenase 1 Homo sapiens 22-25 28208702-1 2017 Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible conversion of glutamate to alpha-ketoglutarate and ammonia while reducing NAD(P)+ to NAD(P)H. NADP 156-163 glutamate dehydrogenase 1 Homo sapiens 25-28 23761034-3 2014 In many organisms this holds also for glutamate dehydrogenases (GDH), NAD(+)-dependent for glutamate oxidation, NADP(+)-dependent for fixing ammonia. NADP 112-119 glutamate dehydrogenase 1 Homo sapiens 64-67 23761034-5 2014 It has been suggested that GDH in mitochondria reacts only with NADP(H), the NAD(+) reaction being an in vitro artefact. NADP 64-71 glutamate dehydrogenase 1 Homo sapiens 27-30 26241911-2 2015 GDH catalyzes the reversible deamination of glutamate to alpha-ketoglutarate while reducing NAD(P) to NAD(P)H. As the generated NADPH can be used in bio-synthetic pathways, we studied here the expression of hGDH1 and hGDH2 in human steroidogenic tissues using specific antibodies. NADP 128-133 glutamate dehydrogenase 1 Homo sapiens 0-3 26241911-2 2015 GDH catalyzes the reversible deamination of glutamate to alpha-ketoglutarate while reducing NAD(P) to NAD(P)H. As the generated NADPH can be used in bio-synthetic pathways, we studied here the expression of hGDH1 and hGDH2 in human steroidogenic tissues using specific antibodies. NADP 128-133 glutamate dehydrogenase 1 Homo sapiens 207-212 26241911-6 2015 As synthesis of steroid hormones requires NADPH, expression of hGDH1 and hGDH2 in steroidogenic cells may serve their particular metabolic needs. NADP 42-47 glutamate dehydrogenase 1 Homo sapiens 63-68