PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34879292-7	2022	shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH of the cancer cells.	NADP	152-156	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	146-151	
34879292-13	2022	The shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH.	NADP	156-160	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	150-155	
30584237-8	2018	This study is the first to demonstrate that modulation of the cellular NADPH:NADP+ ratio by enzymatic action of NQO1 protects acute pancreatitis through the regulation of NOX activity.	NADP	77-82	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	71-76	
34718519-2	2022	The KATP channel-independent pathway is characterized by a rise in several potential metabolic signaling molecules, including the NADPH/NADP+ ratio and alpha-ketoglutarate (alphaKG).	NADP	136-141	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	130-135	
33964586-8	2021	Hyperglycosylation activated glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme in the pentose phosphate pathway, resulting in an upregulation of NADPH/NADP+ and GSH/GSSG couples and enhancement of redox homeostasis in the heart.	NADP	169-174	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	163-168	
30584237-9	2018	Furthermore, these results suggest that modulation of the NADPH:NADP+ ratio in cells by NQO1 may be a novel therapeutic strategy for acute pancreatitis.	NADP	64-69	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	58-63	
28852116-1	2017	Mitochondrial isocitrate dehydrogenase 2 (IDH2) converts NADP+ to NADPH and promotes regeneration of reduced glutathione (GSH) by supplying NADPH to glutathione reductase or thioredoxin reductase.	NADP	57-62	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	66-71	
27474736-1	2016	The forward reaction of nicotinamide nucleotide transhydrogenase (NNT) reduces NADP(+) at the expense of NADH oxidation and H(+) movement down the electrochemical potential across the inner mitochondrial membrane, establishing an NADPH/NADP(+) ratio severalfold higher than the NADH/NAD(+) ratio in the matrix.	NADP	79-86	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	230-235	
27474736-1	2016	The forward reaction of nicotinamide nucleotide transhydrogenase (NNT) reduces NADP(+) at the expense of NADH oxidation and H(+) movement down the electrochemical potential across the inner mitochondrial membrane, establishing an NADPH/NADP(+) ratio severalfold higher than the NADH/NAD(+) ratio in the matrix.	NADP	236-243	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	230-235	
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	NADP	190-195	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	199-204	
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	NADP	190-195	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	250-255	
28473643-7	2017	In contrast, G6pd deficiency resulted in increased activities and protein levels of cytosolic isocitrate dehydrogenase 1, an enzyme that catalyzes the conversion of isocitrate to alpha-ketoglutarate and NADP+ to NADPH, in the inner ear.	NADP	203-208	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	212-217