PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34879292-7 2022 shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH of the cancer cells. NADP 152-156 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 146-151 34879292-13 2022 The shGPX4 plasmid induced ferroptosis by producing ROS and lipid peroxides via downregulating GPX4, while shMTHFD2 triggered apoptosis by modulating NADPH/NADP and depleting GSH. NADP 156-160 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 150-155 30584237-8 2018 This study is the first to demonstrate that modulation of the cellular NADPH:NADP+ ratio by enzymatic action of NQO1 protects acute pancreatitis through the regulation of NOX activity. NADP 77-82 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 71-76 34718519-2 2022 The KATP channel-independent pathway is characterized by a rise in several potential metabolic signaling molecules, including the NADPH/NADP+ ratio and alpha-ketoglutarate (alphaKG). NADP 136-141 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 130-135 33964586-8 2021 Hyperglycosylation activated glucose-6-phosphate dehydrogenase (G6PDH), the rate-limiting enzyme in the pentose phosphate pathway, resulting in an upregulation of NADPH/NADP+ and GSH/GSSG couples and enhancement of redox homeostasis in the heart. NADP 169-174 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 163-168 30584237-9 2018 Furthermore, these results suggest that modulation of the NADPH:NADP+ ratio in cells by NQO1 may be a novel therapeutic strategy for acute pancreatitis. NADP 64-69 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 58-63 28852116-1 2017 Mitochondrial isocitrate dehydrogenase 2 (IDH2) converts NADP+ to NADPH and promotes regeneration of reduced glutathione (GSH) by supplying NADPH to glutathione reductase or thioredoxin reductase. NADP 57-62 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 66-71 27474736-1 2016 The forward reaction of nicotinamide nucleotide transhydrogenase (NNT) reduces NADP(+) at the expense of NADH oxidation and H(+) movement down the electrochemical potential across the inner mitochondrial membrane, establishing an NADPH/NADP(+) ratio severalfold higher than the NADH/NAD(+) ratio in the matrix. NADP 79-86 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 230-235 27474736-1 2016 The forward reaction of nicotinamide nucleotide transhydrogenase (NNT) reduces NADP(+) at the expense of NADH oxidation and H(+) movement down the electrochemical potential across the inner mitochondrial membrane, establishing an NADPH/NADP(+) ratio severalfold higher than the NADH/NAD(+) ratio in the matrix. NADP 236-243 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 230-235 28473643-1 2017 Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems. NADP 190-195 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 199-204 28473643-1 2017 Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems. NADP 190-195 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 250-255 28473643-7 2017 In contrast, G6pd deficiency resulted in increased activities and protein levels of cytosolic isocitrate dehydrogenase 1, an enzyme that catalyzes the conversion of isocitrate to alpha-ketoglutarate and NADP+ to NADPH, in the inner ear. NADP 203-208 2,4-dienoyl CoA reductase 1, mitochondrial Mus musculus 212-217