PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8292022-3 1994 p47phox showed affinities for both oGTP and oATP that were 14 times higher than that for oNADPH, suggesting that it is a nucleoside triphosphate (NTP)-binding protein rather than an NADPH-binding protein. NADP 90-95 neutrophil cytosolic factor 1 Homo sapiens 0-7 7618083-4 1995 Native and recombinant PAKs phosphorylated the p47phox reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase component in a Rac-GTP-dependent manner. NADP 63-106 neutrophil cytosolic factor 1 Homo sapiens 47-54 12065324-14 2002 NADPH-induced superoxide generation was reduced by gp91ds-tat and apocynin, inhibitors of p47phox-gp91phox interactions. NADP 0-5 neutrophil cytosolic factor 1 Homo sapiens 90-97 8961931-1 1996 NADPH-dependent superoxide generation can be reconstituted in a cell-free system using recombinant cytosolic factors (p47-phox, p67-phox, and Rac) plus flavocytochrome b558. NADP 0-5 neutrophil cytosolic factor 1 Homo sapiens 118-126 7896790-5 1995 This activity exhibited an absolute requirement for the cytosolic activating factor p67phox but not for p47phox, suggesting that p67phox and p47phox have individual roles in controlling electron flow from NADPH to oxygen. NADP 205-210 neutrophil cytosolic factor 1 Homo sapiens 141-148 7896790-6 1995 Here, we provide direct evidence that p67phox alone can facilitate electron flow from NADPH to the flavin center of NADPH oxidase in the absence of p47phox, resulting in the reduction of enzyme FAD, whereas the presence of p47phox is required in order for electron transfer to proceed beyond the flavin center to the heme in cytochrome b-245 and thence to oxygen. NADP 86-91 neutrophil cytosolic factor 1 Homo sapiens 223-230 31973815-9 2020 A ROCK active fragment was also able to phosphorylate p47phox at Ser345 residue (p-Ser345 p47phox), a component of NADPH oxidase. NADP 115-120 neutrophil cytosolic factor 1 Homo sapiens 54-61 2124112-1 1990 Two cytosolic proteins, p47-phox and p67-phox, have been shown to be essential components of the NADPH-dependent oxidase of human neutrophils, although the specific role of each of these proteins in the multicomponent electron transport complex is undetermined. NADP 97-102 neutrophil cytosolic factor 1 Homo sapiens 24-32 31961892-10 2020 Further, inhibition of endogenous Atox1 by siRNA in SW620 decreased colony formation and reactive oxygen species generation via decreased expression of Atox1 targets cyclin D1 and NADPH oxidase subunit p47 phox, respectively. NADP 180-185 neutrophil cytosolic factor 1 Homo sapiens 202-210 31704719-1 2020 OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). NADP 96-101 neutrophil cytosolic factor 1 Homo sapiens 52-56 31704719-1 2020 OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). NADP 96-101 neutrophil cytosolic factor 1 Homo sapiens 63-67 31704719-1 2020 OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). NADP 96-101 neutrophil cytosolic factor 1 Homo sapiens 63-67 31704719-1 2020 OBJECTIVES: A single nucleotide polymorphism in the NCF1 gene (NCF1-339, rs201802880), encoding NADPH oxidase type II subunit NCF1/p47phox, reducing production of reactive oxygen species (ROS) is strongly associated with the development of systemic lupus erythematosus (SLE). NADP 96-101 neutrophil cytosolic factor 1 Homo sapiens 131-138 31704719-8 2020 CONCLUSIONS: The NCF1-339 SNP mediated decreased NADPH oxidase function, is associated with high interferon activity and impaired formation of NETs in SLE, allowing dependence on mitochondrial ROS. NADP 49-54 neutrophil cytosolic factor 1 Homo sapiens 17-21 31811262-5 2019 Western blotting was used to analyze the phosphorylation of, p47phox, MAPKinases (p38 and ERK1/2), MEK1/2 and Raf, key proteins involved in the activation of NADPH oxidase. NADP 158-163 neutrophil cytosolic factor 1 Homo sapiens 61-68 31729001-1 2020 The superoxide (O2 -)-generating NADPH oxidase complex of phagocytes comprises a membrane-associated heterodimeric flavocytochrome, known as cytochrome b 558 (consisting of NOX2 and p22phox) and four cytosolic regulatory proteins, p47phox, p67phox, p40phox, and the small GTPase Rac. NADP 34-39 neutrophil cytosolic factor 1 Homo sapiens 232-239 23688784-2 2013 The most common autosomal subtype of CGD is caused by mutations in NCF1, encoding the NADPH subunit p47(phox). NADP 86-91 neutrophil cytosolic factor 1 Homo sapiens 67-71 31732507-0 2019 Correction: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. NADP 63-68 neutrophil cytosolic factor 1 Homo sapiens 42-49 25877604-17 2015 The mRNA expression of NADPH P47-phox of the early-onset preeclampsia in the notch group were significantly higher than that of late-onset preeclampsia in the notch group, late-onset preeclampsia in the non-notch group and the control group (P < 0.01). NADP 23-28 neutrophil cytosolic factor 1 Homo sapiens 29-37 25877604-21 2015 The protein expression of NADPH P47-phox in the placenta of early-onset preeclampsia in the notch group was significantly higher than that of late-onset preeclampsia in the non-notch group and control group (P < 0.05). NADP 26-31 neutrophil cytosolic factor 1 Homo sapiens 32-40 25877604-26 2015 (6)The mRNA expression of placental LCHAD in the early-onset preeclampsia in the notch group was significantly negatively correlated with the mRNA expression of placental NADPH P47-phox and COX-2 (r = - 0.877, -0.762, P < 0.05). NADP 171-176 neutrophil cytosolic factor 1 Homo sapiens 177-185 25877604-28 2015 The protein expression of placental LCHAD in the early-onset preeclampsia in the notch group was significantly negatively correlated with the protein expression of NADPH P47-phox (r = -0.818, P < 0.01). NADP 164-169 neutrophil cytosolic factor 1 Homo sapiens 170-178 23846495-5 2013 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitors (VAS2870 or diphenylene iodonium) significantly attenuated AngII-induced ROS production in CyPA and p47phox-overexpressing CyPA(-/-)VSMC. NADP 0-43 neutrophil cytosolic factor 1 Homo sapiens 171-178 17397983-3 2007 Its activation depends on the interaction with cytosolic regulatory proteins (p67-phox, p47-phox, p40-phox and Rac) leading to an electron transfer from NADPH to molecular oxygen and to the release of superoxide anions. NADP 153-158 neutrophil cytosolic factor 1 Homo sapiens 88-96 15743827-6 2005 This was paralleled by a 2.7- +/- 0.5-fold increase in p47phox-TRAF4 association, membrane translocation of p47phox-TRAF4, a 2.3- +/- 0.4-fold increase in p47phox-p22phox complex formation, and a 3.2- +/- 0.2-fold increase in NADPH-dependent O2- production (all P < 0.05). NADP 226-231 neutrophil cytosolic factor 1 Homo sapiens 55-62 15828232-5 2005 In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators. NADP 147-152 neutrophil cytosolic factor 1 Homo sapiens 120-127 15828232-5 2005 In addition, the phorbol myristate acetate (PMA)-stimulated 22 kDa-subunit (p22phox) protein levels and 47 kDa-subunit (p47phox) protein levels in NADPH (superoxide generating enzyme nicotinamide adenine dinucleotide phosphate (reduced form)) oxidase were decreased by treatment with PPARalpha and PPARgamma ligands/activators. NADP 183-226 neutrophil cytosolic factor 1 Homo sapiens 120-127 17060362-5 2007 Moreover, in a simplified CFS using purified mutant cytochrome b558 and recombinant p67phox, p47phox, and Rac1proteins, we found that the Km for NADPH and for NADH was about three times higher than those of purified WT cytochrome b558, indicating that the Leu505Arg mutation induces a slight decrease of the affinity for NADPH and NADH. NADP 145-150 neutrophil cytosolic factor 1 Homo sapiens 93-100 17060362-5 2007 Moreover, in a simplified CFS using purified mutant cytochrome b558 and recombinant p67phox, p47phox, and Rac1proteins, we found that the Km for NADPH and for NADH was about three times higher than those of purified WT cytochrome b558, indicating that the Leu505Arg mutation induces a slight decrease of the affinity for NADPH and NADH. NADP 321-326 neutrophil cytosolic factor 1 Homo sapiens 93-100 16926363-4 2006 NADPH (nicotinamide adenine dinucleotide phosphate) oxidase is one of the major sources of ROS in vasculature; it consists of a catalytic subunit (Nox1, Nox2, Nox3, Nox4, or Nox5), p22phox, p47phox, p67phox, and the small guanosine triphosphatase Rac1. NADP 0-5 neutrophil cytosolic factor 1 Homo sapiens 190-197