PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20124700-2 2010 The Y224D mutation of AKR1C21 reduced the K(m) value for NADP(H) by up to 80-fold and completely reversed the 17alpha stereospecificity of the enzyme. NADP 57-64 aldo-keto reductase family 1, member C21 Mus musculus 22-29 19237748-2 2009 In this paper, the crystal structure of a double mutant (G225P/G226P) of AKR1C21 in complex with the coenzyme NADP(+) and the inhibitor hexoestrol refined at 2.1 A resolution is presented. NADP 110-114 aldo-keto reductase family 1, member C21 Mus musculus 73-80 17909281-2 2007 The structure of the AKR1C21-NADPH binary complex was determined from an orthorhombic crystal belonging to space group P2(1)2(1)2(1) at a resolution of 1.8 A. NADP 29-34 aldo-keto reductase family 1, member C21 Mus musculus 21-28 17034817-0 2006 Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme. NADP 87-94 aldo-keto reductase family 1, member C21 Mus musculus 28-64