PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27118055-7 2016 Additional deletion of ALD6, which encodes an NADP(+)-dependent acetaldehyde dehydrogenase, led to a 39% increase in the glycerol yield compared to a non-engineered strain. NADP 46-53 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 23-27 21421300-2 2011 Among those enzymes, aldehyde dehydrogenase 6 (ALD6) played the dual roles of direct oxidation of furan derivatives and supply of NADPH cofactor to their reduction reactions. NADP 130-135 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 21-45 27036139-13 2016 Overexpressing ALD6 and ZWF1 mainly increased the [NADPH]/[NADP(+)] and [GSH]/[GSSG] ratios but not the vanillin reductase activities. NADP 51-56 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 15-19 27036139-13 2016 Overexpressing ALD6 and ZWF1 mainly increased the [NADPH]/[NADP(+)] and [GSH]/[GSSG] ratios but not the vanillin reductase activities. NADP 59-66 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 15-19 23103205-6 2013 Furthermore, the overexpression of S. cerevisiae ALD6, IDP2, or S. stipitis ZWF1 coding for cytosolic NADP(+)-dependent dehydrogenases increased the intracellular NADPH availability of the D-10-BT strain, which resulted in a 37-63% improvement in xylitol productivity when cellobiose and xylose were co-consumed. NADP 102-106 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 49-53 23103205-6 2013 Furthermore, the overexpression of S. cerevisiae ALD6, IDP2, or S. stipitis ZWF1 coding for cytosolic NADP(+)-dependent dehydrogenases increased the intracellular NADPH availability of the D-10-BT strain, which resulted in a 37-63% improvement in xylitol productivity when cellobiose and xylose were co-consumed. NADP 163-168 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 49-53 21421300-2 2011 Among those enzymes, aldehyde dehydrogenase 6 (ALD6) played the dual roles of direct oxidation of furan derivatives and supply of NADPH cofactor to their reduction reactions. NADP 130-135 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 47-51 15256563-0 2004 Functional analysis of the ALD gene family of Saccharomyces cerevisiae during anaerobic growth on glucose: the NADP+-dependent Ald6p and Ald5p isoforms play a major role in acetate formation. NADP 111-116 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 127-132 16820460-3 2006 In this study, we evaluated the effects of the overexpression of GPD1, coding for glycerol-3-phosphate dehydrogenase, in three commercial wine yeast strains in which the two copies of ALD6 encoding the NADP+-dependent Mg2+-activated cytosolic acetaldehyde dehydrogenase have been deleted. NADP 202-207 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 184-188 16179340-1 2005 Production of NADPH in Saccharomyces cerevisiae cells grown on glucose has been attributed to glucose-6-phosphate dehydrogenase (Zwf1p) and a cytosolic aldehyde dehydrogenase (Ald6p) (Grabowska, D., and Chelstowska, A. NADP 14-19 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 176-181 14748081-7 2004 This approach was found to enrich the analysis since GND1, ZWF1 and ALD6, encoding the most important enzymes for regeneration of NADPH under anaerobic conditions, were down-regulated together with eight other genes encoding NADP(H)-dependent enzymes. NADP 130-135 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 68-72 14748081-7 2004 This approach was found to enrich the analysis since GND1, ZWF1 and ALD6, encoding the most important enzymes for regeneration of NADPH under anaerobic conditions, were down-regulated together with eight other genes encoding NADP(H)-dependent enzymes. NADP 225-232 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 68-72 12584194-0 2003 The ALD6 gene product is indispensable for providing NADPH in yeast cells lacking glucose-6-phosphate dehydrogenase activity. NADP 53-58 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 4-8 12584194-7 2003 We found that overexpression of the ALD6 gene coding for cytosolic acetaldehyde dehydrogenase, which utilizes NADP(+) as its cofactor, restores the Met(+) phenotype of the zwf1Delta strain. NADP 110-117 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 36-40 10919763-6 2000 In contrast, strains with one or two disrupted copies of ALD6, encoding the cytosolic Mg(2+)-activated NADP-dependent ACDH and exhibiting 60 and 30% of wild-type ACDH activity, showed a substantial decrease in acetate yield (the acetate production was 75 and 40% of wild-type production, respectively). NADP 103-107 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 57-61 15146068-4 2004 This screen yielded a number of genes not previously implicated in salt stress, including ALD6, which encodes an NADP(+)-dependent aldehyde dehydrogenase, and UTR1, which encodes an NAD+ kinase. NADP 113-117 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 90-94 15146068-6 2004 In addition, screening of the deletion strains for hypersensitivity to SFK2 yielded ZWF1, encoding glucose-6-phosphate dehydrogenase, which has been shown to play an overlapping role with Ald6p in NADPH production. NADP 197-202 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 188-193 15146068-8 2004 Having established that the SFKs target Ald6p, they were used as tools to implicate systematically other gene products in the Ald6p pathway, including Utr1p, which may function by supplying Ald6p with its NADP+ cofactor. NADP 205-209 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 40-45 15146068-8 2004 Having established that the SFKs target Ald6p, they were used as tools to implicate systematically other gene products in the Ald6p pathway, including Utr1p, which may function by supplying Ald6p with its NADP+ cofactor. NADP 205-209 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 126-131 15146068-8 2004 Having established that the SFKs target Ald6p, they were used as tools to implicate systematically other gene products in the Ald6p pathway, including Utr1p, which may function by supplying Ald6p with its NADP+ cofactor. NADP 205-209 aldehyde dehydrogenase (NADP(+)) ALD6 Saccharomyces cerevisiae S288C 126-131